VU0366248

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558403

CAS#: 1243310-20-4

Description: VU0366248 is a negative allosteric modulator of mGlu5.

Chemical Structure

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VU0366248
CAS# 1243310-20-4
Instruction

Theoretical Analysis

MedKoo Cat#: 558403
Name: VU0366248
CAS#: 1243310-20-4
Chemical Formula: C14H7ClF2N2O
Exact Mass: 292.02
Molecular Weight: 292.670
Elemental Analysis: C, 57.46; H, 2.41; Cl, 12.11; F, 12.98; N, 9.57; O, 5.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: VU0366248; VU-0366248; VU 0366248;

IUPAC/Chemical Name: N-(3-Chloro-2-fluorophenyl)-3-cyano-5-fluoro-benzamide

InChi Key: QDFPSPIHFOODSP-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H7ClF2N2O/c15-11-2-1-3-12(13(11)17)19-14(20)9-4-8(7-18)5-10(16)6-9/h1-6H,(H,19,20)

SMILES Code: O=C(NC1=CC=CC(Cl)=C1F)C2=CC(F)=CC(C#N)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 292.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site Karen J. Gregory, Elizabeth D. Nguyen, Chrysa Malosh, Jeffrey L. Mendenhall, Jessica Z. Zic, Brittney S. Bates, Meredith J. Noetzel, Emma F. Squire, Eric M. Turner, Jerri M. Rook, Kyle A. Emmitte, Shaun R. Stauffer, Craig W. Lindsley, Jens Meiler, P. Jeffrey Conn ACS Chem Neurosci. 2014 Apr 16; 5(4): 282–295. Published online 2014 Feb 16. doi: 10.1021/cn400225x PMCID: PMC3990945

2: Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships Karen J. Gregory, Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Shaun R. Stauffer, Alice L. Rodriguez, Kyle A. Emmitte, Ya Zhou, Aspen C. Chun, Andrew S. Felts, Brian A. Chauder, Craig W. Lindsley, Colleen M. Niswender, P. Jeffrey Conn Mol Pharmacol. 2012 Nov; 82(5): 860–875. doi: 10.1124/mol.112.080531 PMCID: PMC3477233

3: VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy Hilary Highfield Nickols, Joannes P. Yuh, Karen J. Gregory, Ryan D. Morrison, Brittney S. Bates, Shaun R. Stauffer, Kyle A. Emmitte, Michael Bubser, Weimin Peng, Michael T. Nedelcovych, Analisa Thompson, Xiaohui Lv, Zixiu Xiang, J. Scott Daniels, Colleen M. Niswender, Craig W. Lindsley, Carrie K. Jones, P. Jeffrey Conn J Pharmacol Exp Ther. 2016 Jan; 356(1): 123–136. Published online 2016 Jan. doi: 10.1124/jpet.115.226597 PMCID: PMC4702078

4: Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation Karen J. Gregory, P. Jeffrey Conn Mol Pharmacol. 2015 Jul; 88(1): 188–202. Published online 2015 Jul. doi: 10.1124/mol.114.097220 PMCID: PMC4468636