VU0183254

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558402

CAS#: 663212-40-6

Description: VU0183254 is an antagonist of insect olfactory receptors (ORs) acting at a binding site on the Orco subunit, capable of broadly inhibiting odor-mediated OR complex activation.


Chemical Structure

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VU0183254
CAS# 663212-40-6

Theoretical Analysis

MedKoo Cat#: 558402
Name: VU0183254
CAS#: 663212-40-6
Chemical Formula: C22H18N4O2S2
Exact Mass: 434.09
Molecular Weight: 434.530
Elemental Analysis: C, 60.81; H, 4.18; N, 12.89; O, 7.36; S, 14.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VU0183254; VU-0183254; VU 0183254; VUANT 1;

IUPAC/Chemical Name: 2-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-1-phenothiazin-10-yl-ethanone

InChi Key: ASZRHXKUEMHBKN-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H18N4O2S2/c1-2-25-21(17-10-7-13-28-17)23-24-22(25)29-14-20(27)26-15-8-3-5-11-18(15)30-19-12-6-4-9-16(19)26/h3-13H,2,14H2,1H3

SMILES Code: CCN1C(SCC(N2C3=C(C=CC=C3)SC4=CC=CC=C24)=O)=NN=C1C5=CC=CO5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 434.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jones PL, Pask GM, Romaine IM, Taylor RW, Reid PR, Waterson AG, Sulikowski GA, Zwiebel LJ. Allosteric antagonism of insect odorant receptor ion channels. PLoS One. 2012;7(1):e30304. doi: 10.1371/journal.pone.0030304. Epub 2012 Jan 17. PubMed PMID: 22272331; PubMed Central PMCID: PMC3260273.

2: Chen S, Luetje CW. Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit. PLoS One. 2012;7(5):e36784. doi: 10.1371/journal.pone.0036784. Epub 2012 May 8. PubMed PMID: 22590607; PubMed Central PMCID: PMC3348135.