M-110
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MedKoo CAT#: 558399

CAS#: 1395048-49-3

Description: M-110 is a inhibitor of protein arginine N-methyltransferases (PRMTs). It is also a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3, shown to inhibit the proliferation of prostate cancer cell lines with IC50s between 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 270 2 Weeks
25mg USD 460 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-06-07. Prices are subject to change without notice.

M-110, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 558399
Name: M-110
CAS#: 1395048-49-3
Chemical Formula: C22H28ClN5O3
Exact Mass: 445.19
Molecular Weight: 445.95
Elemental Analysis: C, 59.25; H, 6.33; Cl, 7.95; N, 15.70; O, 10.76


Synonym: M-110; M 110; M110;

IUPAC/Chemical Name: (E)-2-(3-Morpholin-4-yl-propylamino)-isonicotinic acid [1-(4-chloro-2-hydroxy-phenyl)-propylidene]-hydrazide

InChi Key: FXXCNYVQIONABS-LGUFXXKBSA-N

InChi Code: InChI=1S/C22H28ClN5O3/c1-2-19(18-5-4-17(23)15-20(18)29)26-27-22(30)16-6-8-25-21(14-16)24-7-3-9-28-10-12-31-13-11-28/h4-6,8,14-15,29H,2-3,7,9-13H2,1H3,(H,24,25)(H,27,30)/b26-19+

SMILES Code: O=C(N/N=C(C1=CC=C(Cl)C=C1O)\CC)C2=CC=NC(NCCCN3CCOCC3)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Gailly P, Wu X, Haystead TA, Somlyo AP, Cohen PT, Cohen P, Somlyo AV. Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle. Eur J Biochem. 1996 Jul 15;239(2):326-32. PubMed PMID: 8706736.

2: Johnson D, Cohen P, Chen MX, Chen YH, Cohen PT. Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin. Eur J Biochem. 1997 Mar 15;244(3):931-9. PubMed PMID: 9108268.

3: Johnson DF, Moorhead G, Caudwell FB, Cohen P, Chen YH, Chen MX, Cohen PT. Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits. Eur J Biochem. 1996 Jul 15;239(2):317-25. PubMed PMID: 8706735.

4: Calhoun MW, Lemieux LJ, Garcia-Horsman JA, Thomas JW, Alben JO, Gennis RB. The highly conserved methionine of subunit I of the heme-copper oxidases is not at the heme-copper dinuclear center: mutagenesis of M110 in subunit I of cytochrome bo3-type ubiquinol oxidase from Escherichia coli. FEBS Lett. 1995 Jul 24;368(3):523-5. PubMed PMID: 7635213.

5: Dvir H, Choe S. Bacterial expression of a eukaryotic membrane protein in fusion to various Mistic orthologs. Protein Expr Purif. 2009 Nov;68(1):28-33. doi: 10.1016/j.pep.2009.06.007. Epub 2009 Jun 12. PubMed PMID: 19524676; PubMed Central PMCID: PMC2728152.

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7: Djiane J, Dusanter-Fourt I, Katoh M, Kelly PA. Biological activities of binding site specific monoclonal antibodies to prolactin receptors of rabbit mammary gland. J Biol Chem. 1985 Sep 25;260(21):11430-5. PubMed PMID: 2995334.

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10: Guo LT, Helgadóttir S, Söll D, Ling J. Rational design and directed evolution of a bacterial-type glutaminyl-tRNA synthetase precursor. Nucleic Acids Res. 2012 Sep;40(16):7967-74. doi: 10.1093/nar/gks507. Epub 2012 May 31. PubMed PMID: 22661575; PubMed Central PMCID: PMC3439900.

11: Sands NB, Adamson PA. Nasal tip deprojection with crural cartilage overlap: the M-arch model. Facial Plast Surg Clin North Am. 2015 Feb;23(1):93-104. doi: 10.1016/j.fsc.2014.09.007. Review. PubMed PMID: 25430931.

12: Dvir H, Lundberg ME, Maji SK, Riek R, Choe S. Mistic: cellular localization, solution behavior, polymerization, and fibril formation. Protein Sci. 2009 Jul;18(7):1564-70. doi: 10.1002/pro.148. PubMed PMID: 19475664; PubMed Central PMCID: PMC2775223.

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15: Chen YH, Chen MX, Alessi DR, Campbell DG, Shanahan C, Cohen P, Cohen PT. Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. FEBS Lett. 1994 Dec 12;356(1):51-5. PubMed PMID: 7988720.

16: Yuan H, Amin R, Ye X, de la Motte CA, Cowman MK. Determination of hyaluronan molecular mass distribution in human breast milk. Anal Biochem. 2015 Apr 1;474:78-88. doi: 10.1016/j.ab.2014.12.020. Epub 2015 Jan 9. PubMed PMID: 25579786; PubMed Central PMCID: PMC4357551.

17: MacDonald JA, Eto M, Borman MA, Brautigan DL, Haystead TA. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. FEBS Lett. 2001 Mar 30;493(2-3):91-4. PubMed PMID: 11287002.

18: Dong J, Ren L, Zhang Y, Cui X, Hu P, Xu J. Direct electrodeposition of cable-like CuO@Cu nanowires array for non-enzymatic sensing. Talanta. 2015 Jan;132:719-26. doi: 10.1016/j.talanta.2014.10.027. Epub 2014 Oct 22. PubMed PMID: 25476370.

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