Jmv 320

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597746

CAS#: 130582-10-4

Description: Jmv 320 is a cyclic cholecystokinin-8 analog in which positions 28 and 31 have been replaced by Lys, with their side chains bridged by a succinic moiety; highly selective gastrin receptor and cholecystokinin receptor antagonist.

Chemical Structure

Jmv 320
CAS# 130582-10-4

Theoretical Analysis

MedKoo Cat#: 597746
Name: Jmv 320
CAS#: 130582-10-4
Chemical Formula: C53H67N11O13
Exact Mass: 1065.492
Molecular Weight: 1066.18
Elemental Analysis: C, 59.71; H, 6.33; N, 14.45; O, 19.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Jmv 320; Jmv-320; Jmv320;

IUPAC/Chemical Name: (S)-3-((5S,8S,23S)-5-((1H-indol-3-yl)methyl)-23-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3,6,14,17,24-pentaoxo-1,4,7,13,18-pentaazacyclotetracosane-8-carboxamido)-4-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid


InChi Code: 1S/C53H67N11O13/c1-31(65)59-41(26-33-17-19-35(66)20-18-33)51(75)61-38-15-7-9-23-55-44(67)21-22-45(68)56-24-10-8-16-39(50(74)64-43(28-47(70)71)53(77)63-40(48(54)72)25-32-11-3-2-4-12-32)62-52(76)42(60-46(69)30-58-49(38)73)27-34-29-57-37-14-6-5-13-36(34)37/h2-6,11-14,17-20,29,38-43,57,66H,7-10,15-16,21-28,30H2,1H3,(H2,54,72)(H,55,67)(H,56,68)(H,58,73)(H,59,65)(H,60,69)(H,61,75)(H,62,76)(H,63,77)(H,64,74)(H,70,71)/t38-,39-,40-,41-,42-,43-/m0/s1

SMILES Code: CC(N[C@H](C(N[C@H]1CCCCNC(CCC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N)=O)Cc2ccccc2)=O)CC(O)=O)=O)NC([C@H](Cc3c4ccccc4[nH]c3)NC(CNC1=O)=O)=O)=O)=O)=O)Cc5ccc(O)cc5)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1066.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Witte DG, Nadzan AM, Martinez J, Rodriguez M, Lin CW. Characterization of the novel CCK analogs JMV-180, JMV-320, and JMV-332 in H345 cells. Peptides. 1992 Nov-Dec;13(6):1227-32. PubMed PMID: 1337381.

2: Hadjiivanova C, Kehayov R, Petkov VV, Amblard M, Martinez J. Behavioral effects of the cyclic cholecystokinin peptide analogue JMV-320. Peptides. 1995;16(5):815-9. PubMed PMID: 7479320.

3: Ishizuka J, Martinez J, Townsend CM Jr, Thompson JC. The effect of gastrin on growth of human stomach cancer cells. Ann Surg. 1992 May;215(5):528-34. PubMed PMID: 1616389; PubMed Central PMCID: PMC1242491.

4: Lignon MF, Bernad N, Martinez J. Cholecystokinin receptors in cells of the immune system. Ann N Y Acad Sci. 1994 Mar 23;713:334-7. PubMed PMID: 8185180.