BC 197

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MedKoo CAT#: 597743

CAS#: 115295-08-4

Description: BC 197 is a selective CCK-B agonist.

Price and Availability

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Pricing updated 2020-10-19. Prices are subject to change without notice.

BC 197 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 597743
Name: BC 197
CAS#: 115295-08-4
Chemical Formula: C60H81N11O17S
Exact Mass: 1259.5533
Molecular Weight: 1260.42
Elemental Analysis: C, 57.18; H, 6.48; N, 12.22; O, 21.58; S, 2.54

Synonym: BC 197; BC-197; BC197; Boc-asp-tyr(SO3H)-ahx-lys-trp-ahx-asp-phe-NH2;

IUPAC/Chemical Name: (2S,5S,8R,11S,14S,17S,20S,24R)-11-((1H-indol-3-yl)methyl)-2-amino-8-(4-aminobutyl)-20-benzyl-5-((E)-buta-1,3-dien-1-yl)-24-((tert-butoxycarbonyl)amino)-14-butyl-1-(4-hydroxyphenyl)-3,9,12,15,18,21,23-heptaoxo-17-(2-oxo-2-(sulfooxy)ethyl)-4,7,10,13,16,19,22-heptaazahexacosan-26-oic acid


InChi Code: 1S/C60H81N11O17S/c1-6-8-19-39(65-52(76)42(62)29-37-24-26-40(72)27-25-37)35-64-44(23-15-16-28-61)53(77)68-47(31-38-34-63-43-22-14-13-20-41(38)43)55(79)66-45(21-9-7-2)54(78)69-49(33-51(75)88-89(84,85)86)56(80)67-46(30-36-17-11-10-12-18-36)57(81)71-58(82)48(32-50(73)74)70-59(83)87-60(3,4)5/h6,8,10-14,17-20,22,24-27,34,39,42,44-49,63-64,72H,1,7,9,15-16,21,23,28-33,35,61-62H2,2-5H3,(H,65,76)(H,66,79)(H,67,80)(H,68,77)(H,69,78)(H,70,83)(H,73,74)(H,71,81,82)(H,84,85,86)/b19-8+/t39-,42-,44+,45-,46-,47-,48+,49-/m0/s1

SMILES Code: CCCC[C@H](NC([C@@H](NC([C@H](NC[C@@H](NC([C@@H](N)Cc1ccc(O)cc1)=O)/C=C/C=C)CCCCN)=O)Cc2c3ccccc3[nH]c2)=O)C(N[C@H](C(N[C@H](C(NC([C@H](NC(OC(C)(C)C)=O)CC(O)=O)=O)=O)Cc4ccccc4)=O)CC(OS(=O)(O)=O)=O)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Derrien M, McCort-Tranchepain I, Ducos B, Roques BP, Durieux C. Heterogeneity of CCK-B receptors involved in animal models of anxiety. Pharmacol Biochem Behav. 1994 Sep;49(1):133-41. PubMed PMID: 7816864.

2: Léna I, Simon H, Roques BP, Daugé V. Opposing effects of two CCK(B) agonists on the retrieval phase of a two-trial memory task after systemic injection in the rat. Neuropharmacology. 1999 Apr;38(4):543-53. PubMed PMID: 10221758.

3: Léna I, Roques BP, Durieux C. Dual modulation of dopamine release from anterior nucleus accumbens through cholecystokinin-B receptor subsites. J Neurochem. 1997 Jan;68(1):162-8. PubMed PMID: 8978722.

4: Heidbreder C, Roques BP, De Witte P. Similar potencies of CCK-8 and its analogue BOC(Nle28;Nle31)CCK27-33 on the self-stimulation behaviour both are antagonized by a newly synthesized cyclic CCK analogue. Neuropeptides. 1989 Feb-Mar;13(2):89-94. PubMed PMID: 2739884.

5: Derrien M, Durieux C, Roques BP. Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole. Br J Pharmacol. 1994 Mar;111(3):956-60. PubMed PMID: 8019773; PubMed Central PMCID: PMC1910081.

6: Léna I, Dh tel H, Garbay C, Daugé V. Involvement of D2 dopamine receptors in the opposing effects of two CCK-B agonists in a spatial recognition memory task: role of the anterior nucleus accumbens. Psychopharmacology (Berl). 2001 Jan 1;153(2):170-9. PubMed PMID: 11205416.

7: Durieux C, Derrien M, Maldonado R, Valverde O, Blommaert A, Fournié-Zaluski MC, Roques BP. CCK-B antagonists exhibit antidepressant-like effects and potentiate endogenous enkephalin analgesia. Correlation with in vivo binding affinities and brain penetration. Ann N Y Acad Sci. 1994 Mar 23;713:355-7. PubMed PMID: 8185186.

8: Ladurelle N, Sebret A, Garbay C, Roques BP, Daugé V. Opposite effects of CCK(B) agonists in grooming behaviour in rats: further evidence for two CCK(B) subsites. Br J Pharmacol. 1998 Jul;124(6):1091-8. PubMed PMID: 9720778; PubMed Central PMCID: PMC1565489.