Jmv 236

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597742

CAS#: 113137-57-8

Description: Jmv 236 is a cholecystokinin antagonist.


Chemical Structure

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Jmv 236
CAS# 113137-57-8

Theoretical Analysis

MedKoo Cat#: 597742
Name: Jmv 236
CAS#: 113137-57-8
Chemical Formula: C56H74N10O18S
Exact Mass: 1206.4903
Molecular Weight: 1207.32
Elemental Analysis: C, 55.71; H, 6.18; N, 11.60; O, 23.85; S, 2.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Jmv 236; Jmv-236; Jmv236; t-Boc(nle(28,31))-cck (26-33);

IUPAC/Chemical Name: (3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-19-(tert-butoxycarbonyl)-6,15-dibutyl-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosanedioic acid

InChi Key: MVTSFWYNRALKOI-JBNHEJHRSA-N

InChi Code: InChI=1S/C56H74N10O18S/c1-6-8-18-39(63-53(77)44(26-33-21-23-35(24-22-33)84-85(80,81)82)66(55(79)83-56(3,4)5)54(78)37(57)28-46(68)69)49(73)60-31-45(67)61-42(27-34-30-59-38-20-14-13-17-36(34)38)51(75)62-40(19-9-7-2)50(74)65-43(29-47(70)71)52(76)64-41(48(58)72)25-32-15-11-10-12-16-32/h10-17,20-24,30,37,39-44,59H,6-9,18-19,25-29,31,57H2,1-5H3,(H2,58,72)(H,60,73)(H,61,67)(H,62,75)(H,63,77)(H,64,76)(H,65,74)(H,68,69)(H,70,71)(H,80,81,82)/t37-,39-,40-,41-,42-,43-,44-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCCC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCCC)NC([C@H](CC4=CC=C(OS(=O)(O)=O)C=C4)N(C([C@H](CC(O)=O)N)=O)C(OC(C)(C)C)=O)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1207.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hadjiivanova C, Petkov VV, Kehayov R, Martinez J. Behavioural effects of two cholecystokinin analogues: JMV 236 and JMV 179. Neuropeptides. 1994 Sep;27(3):163-7. PubMed PMID: 7816187.

2: Camby I, Salmon I, Danguy A, Pasteels JL, Brotchi J, Martinez J, Kiss R. Influence of gastrin on human astrocytic tumor cell proliferation. J Natl Cancer Inst. 1996 May 1;88(9):594-600. PubMed PMID: 8609660.

3: Nagain C, Lignon MF, Galas MC, Rodriguez M, Martinez J, Rozé C. Large and prolonged in vivo response of pancreatic secretion to phenylethylamide and phenylethylester derivatives of Boc-[Nle28-Nle31]CCK(26-33) in the rat. Peptides. 1992 Nov-Dec;13(6):1127-32. PubMed PMID: 1494494.

4: Gourch A, Orosco M, Rodriguez M, Martinez J, Jacquot C, Cohen Y. A cholecystokinin agonist/antagonist according to dose and time of action: effect on food intake. Neuropeptides. 1990 Dec;17(4):187-91. PubMed PMID: 2093151.

5: Pages N, Gourch A, Orosco M, Comoy E, Bohuon C, Rodriguez M, Martinez J, Jacquot C, Cohen Y. Changes in brain neuropeptide Y induced by cholecystokinin peptides. Neuropeptides. 1990 Nov;17(3):141-5. PubMed PMID: 2084577.

6: Nagain C, Mendre C, Rodriguez M, Bernard C, Martinez J, Rozé C. External pancreatic secretion in the rat: supramaximal inhibition induced by the cholecystokinin octapeptide [CCK(26-33)] and analogs altered on the 28-29 bond. Peptides. 1989 Sep-Oct;10(5):1041-7. PubMed PMID: 2481847.