U 67827E

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597740

CAS#: 103494-23-1

Description: U 67827E is a long-lasting cholecystokinin agonist U 67827E decreases food intake.

Chemical Structure

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U 67827E
CAS# 103494-23-1
Instruction

Theoretical Analysis

MedKoo Cat#: 597740
Name: U 67827E
CAS#: 103494-23-1
Chemical Formula: C53H68N10O17S
Exact Mass: 1,148.45
Molecular Weight: 1,149.240
Elemental Analysis: C, 55.39; H, 5.96; N, 12.19; O, 23.67; S, 2.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: U 67827E; U-67827E; U67827E; N-Ac-Asp-tyr(So3H)-nle-gly-trp-nle-asp-phe-NH2;

IUPAC/Chemical Name: (3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-19-acetyl-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-dibutyl-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosanedioic acid

InChi Key: FXRJJLGINFLBGK-TZLMNZOISA-N

InChi Code: InChI=1S/C53H68N10O17S/c1-4-6-16-38(60-52(75)43(63(30(3)64)53(76)36(54)26-45(66)67)24-32-19-21-34(22-20-32)80-81(77,78)79)48(71)57-29-44(65)58-41(25-33-28-56-37-18-12-11-15-35(33)37)50(73)59-39(17-7-5-2)49(72)62-42(27-46(68)69)51(74)61-40(47(55)70)23-31-13-9-8-10-14-31/h8-15,18-22,28,36,38-43,56H,4-7,16-17,23-27,29,54H2,1-3H3,(H2,55,70)(H,57,71)(H,58,65)(H,59,73)(H,60,75)(H,61,74)(H,62,72)(H,66,67)(H,68,69)(H,77,78,79)/t36-,38-,39-,40-,41-,42-,43-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCCC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCCC)NC([C@H](CC4=CC=C(OS(=O)(O)=O)C=C4)N(C([C@H](CC(O)=O)N)=O)C(C)=O)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,149.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Moran TH, Sawyer TK, Seeb DH, Ameglio PJ, Lombard MA, McHugh PR. Potent and sustained satiety actions of a cholecystokinin octapeptide analogue. Am J Clin Nutr. 1992 Jan;55(1 Suppl):286S-290S. doi: 10.1093/ajcn/55.1.286s. PubMed PMID: 1728841.

2: Foltin RW, Moran TH. Food intake in baboons: effects of a long-acting cholecystokinin analog. Appetite. 1989 Apr;12(2):145-52. PubMed PMID: 2764555.

3: Schwartz GJ, Netterville LA, McHugh PR, Moran TH. Gastric loads potentiate inhibition of food intake produced by a cholecystokinin analogue. Am J Physiol. 1991 Nov;261(5 Pt 2):R1141-6. PubMed PMID: 1951762.