Gatratet

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MedKoo CAT#: 597728

CAS#: 2283-80-9

Description: Gatratet is a tetrapeptide.


Price and Availability

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Pricing updated 2020-03-29. Prices are subject to change without notice.

Gatratet is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597728
Name: Gatratet
CAS#: 2283-80-9
Chemical Formula: C37H42N6O8S
Exact Mass: 730.2785
Molecular Weight: 730.83
Elemental Analysis: C, 60.81; H, 5.79; N, 11.50; O, 17.51; S, 4.39


Synonym: Gatratet; Carbobenzoxy-trp-met-asp-phe-amide;

IUPAC/Chemical Name: (5S,8S,11S)-5-((1H-indol-3-yl)methyl)-11-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-8-(2-(methylthio)ethyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid

InChi Key: DLOHHVQNOMRHQK-ORYMTKCHSA-N

InChi Code: InChI=1S/C37H42N6O8S/c1-52-17-16-28(34(47)42-31(20-32(44)45)36(49)41-29(33(38)46)18-23-10-4-2-5-11-23)40-35(48)30(19-25-21-39-27-15-9-8-14-26(25)27)43-37(50)51-22-24-12-6-3-7-13-24/h2-15,21,28-31,39H,16-20,22H2,1H3,(H2,38,46)(H,40,48)(H,41,49)(H,42,47)(H,43,50)(H,44,45)/t28-,29-,30-,31-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(OCC4=CC=CC=C4)=O)=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Saugar JM, Merino FJ, Martín-Rabadán P, Fernández-Soto P, Ortega S, Gárate T, Rodríguez E. Application of real-time PCR for the detection of Strongyloides spp. in clinical samples in a reference center in Spain. Acta Trop. 2015 Feb;142:20-5. doi: 10.1016/j.actatropica.2014.10.020. Epub 2014 Nov 4. PubMed PMID: 25447829.

2: Monreal-Escalante E, Bañuelos-Hernández B, Hernández M, Fragoso G, Garate T, Sciutto E, Rosales-Mendoza S. Expression of Multiple Taenia Solium Immunogens in Plant Cells Through a Ribosomal Skip Mechanism. Mol Biotechnol. 2015 Jul;57(7):635-43. doi: 10.1007/s12033-015-9853-6. PubMed PMID: 25761936.

3: Valdivieso E, Perteguer MJ, Hurtado C, Campioli P, Rodríguez E, Saborido A, Martínez-Sernández V, Gómez-Puertas P, Ubeira FM, Gárate T. ANISERP: a new serpin from the parasite Anisakis simplex. Parasit Vectors. 2015 Jul 28;8:399. doi: 10.1186/s13071-015-1006-z. PubMed PMID: 26215984; PubMed Central PMCID: PMC4517634.

4: Rivera MG, Herrera L, Morocoima A, Aguilar CM, Gárate T, López M, Lares M, Viettri M, Ferrer E. Genetic variability of Trypanosoma cruzi TcI isolates from rural and urban areas of Venezuela. J Vector Borne Dis. 2015 Mar;52(1):23-9. PubMed PMID: 25815863.

5: Pastor-Valle J, González LM, Martín-Clemente JP, Merino FJ, Gottstein B, Gárate T. Molecular diagnosis of diphyllobothriasis in Spain, most presumably acquired via imported fish, or sojourn abroad. New Microbes New Infect. 2014 Jan;2(1):1-6. doi: 10.1002/2052-2975.28. Epub 2014 Jan 15. PubMed PMID: 25356331; PubMed Central PMCID: PMC4184615.

6: Martínez-Sernández V, Mezo M, González-Warleta M, Perteguer MJ, Muiño L, Guitián E, Gárate T, Ubeira FM. The MF6p/FhHDM-1 major antigen secreted by the trematode parasite Fasciola hepatica is a heme-binding protein. J Biol Chem. 2014 Jan 17;289(3):1441-56. doi: 10.1074/jbc.M113.499517. Epub 2013 Nov 26. PubMed PMID: 24280214; PubMed Central PMCID: PMC3894327.

7: Gottstein B, Schneeberger M, Boubaker G, Merkle B, Huber C, Spiliotis M, Müller N, Garate T, Doherr MG. Comparative assessment of ELISAs using recombinant saposin-like protein 2 and recombinant cathepsin L-1 from Fasciola hepatica for the serodiagnosis of human Fasciolosis. PLoS Negl Trop Dis. 2014 Jun 12;8(6):e2860. doi: 10.1371/journal.pntd.0002860. eCollection 2014 Jun. PubMed PMID: 24922050; PubMed Central PMCID: PMC4055579.

8: Herrador Z, Siles-Lucas M, Aparicio P, Lopez-Velez R, Gherasim A, Garate T, Benito A. Cystic Echinococcosis Epidemiology in Spain Based on Hospitalization Records, 1997-2012. PLoS Negl Trop Dis. 2016 Aug 22;10(8):e0004942. doi: 10.1371/journal.pntd.0004942. eCollection 2016 Aug. PubMed PMID: 27547975; PubMed Central PMCID: PMC4993502.

9: Moya L, Herrador Z, Ta-Tang TH, Rubio JM, Perteguer MJ, Hernandez-González A, García B, Nguema R, Nguema J, Ncogo P, Garate T, Benito A, Sima A, Aparicio P. Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. PLoS Negl Trop Dis. 2016 Jul 22;10(7):e0004829. doi: 10.1371/journal.pntd.0004829. eCollection 2016 Jul. PubMed PMID: 27448085; PubMed Central PMCID: PMC4957785.

10: Hernández-González A, Moya L, Perteguer MJ, Herrador Z, Nguema R, Nguema J, Aparicio P, Benito A, Gárate T. Evaluation of onchocerciasis seroprevalence in Bioko Island (Equatorial Guinea) after years of disease control programmes. Parasit Vectors. 2016 Sep 20;9(1):509. doi: 10.1186/s13071-016-1779-8. PubMed PMID: 27645887; PubMed Central PMCID: PMC5028998.

11: Laurimäe T, Kinkar L, Andresiuk V, Haag KL, Ponce-Gordo F, Acosta-Jamett G, Garate T, Gonzàlez LM, Saarma U. Genetic diversity and phylogeography of highly zoonotic Echinococcus granulosus genotype G1 in the Americas (Argentina, Brazil, Chile and Mexico) based on 8279bp of mtDNA. Infect Genet Evol. 2016 Nov;45:290-296. doi: 10.1016/j.meegid.2016.09.015. Epub 2016 Sep 19. PubMed PMID: 27659214.

12: Martínez-Ibeas AM, Perteguer MJ, González-Lanza C, Gárate T, Manga-González MY. Analysis of an expressed sequence tag library from Dicrocoelium dentriticum. Exp Parasitol. 2013 Oct;135(2):287-96. doi: 10.1016/j.exppara.2013.07.005. Epub 2013 Jul 19. PubMed PMID: 23872427.

13: Perteguer MJ, Gómez-Puertas P, Cañavate C, Dagger F, Gárate T, Valdivieso E. Ddi1-like protein from Leishmania major is an active aspartyl proteinase. Cell Stress Chaperones. 2013 Mar;18(2):171-81. doi: 10.1007/s12192-012-0368-9. Epub 2012 Aug 30. PubMed PMID: 22933181; PubMed Central PMCID: PMC3581629.

14: González LM, Ramiro R, García L, Parkhouse RM, McManus DP, Gárate T. Genetic variability of the 18 kDa/HP6 protective antigen in Taenia saginata and Taenia asiatica: implications for vaccine development. Mol Biochem Parasitol. 2011 Apr;176(2):131-4. doi: 10.1016/j.molbiopara.2010.12.014. Epub 2011 Jan 11. PubMed PMID: 21232558.

15: Monreal-Escalante E, Govea-Alonso DO, Hernández M, Cervantes J, Salazar-González JA, Romero-Maldonado A, Rosas G, Garate T, Fragoso G, Sciutto E, Rosales-Mendoza S. Towards the development of an oral vaccine against porcine cysticercosis: expression of the protective HP6/TSOL18 antigen in transgenic carrots cells. Planta. 2016 Mar;243(3):675-85. doi: 10.1007/s00425-015-2431-0. Epub 2015 Nov 27. PubMed PMID: 26613600.

16: Muiño L, Perteguer MJ, Gárate T, Martínez-Sernández V, Beltrán A, Romarís F, Mezo M, González-Warleta M, Ubeira FM. Molecular and immunological characterization of Fasciola antigens recognized by the MM3 monoclonal antibody. Mol Biochem Parasitol. 2011 Oct;179(2):80-90. doi: 10.1016/j.molbiopara.2011.06.003. Epub 2011 Jun 25. PubMed PMID: 21723885.

17: González LM, Bailo B, Ferrer E, García MD, Harrison LJ, Parkhouse MR, McManus DP, Gárate T. Characterization of the Taenia spp HDP2 sequence and development of a novel PCR-based assay for discrimination of Taenia saginata from Taenia asiatica. Parasit Vectors. 2010 Jun 11;3:51. doi: 10.1186/1756-3305-3-51. PubMed PMID: 20540755; PubMed Central PMCID: PMC2906438.

18: Paniz-Mondolfi AE, Gárate T, Stavropoulos C, Fan W, González LM, Eberhard M, Kimmelstiel F, Sordillo EM. Zoonotic filariasis caused by novel Brugia sp. nematode, United States, 2011. Emerg Infect Dis. 2014 Jul;20(7):1248-50. doi: 10.3201/eid2007.131654. PubMed PMID: 24963722; PubMed Central PMCID: PMC4073870.

19: Fonseca-Salamanca F, Nogal-Ruiz JJ, García-Sánchez RN, Bolas-Fernandez F, Jiménez S, Alamo R, Gárate T, Martínez-Fernandez AR. Prevalence of Trichinella spp. in North Spain wild fauna and new variety of Trichinella britovi identification. Vet Parasitol. 2009 Feb 23;159(3-4):222-4. doi: 10.1016/j.vetpar.2008.10.040. Epub 2008 Oct 22. PubMed PMID: 19084339.

20: Perteguer MJ, Rodríguez E, García-Sánchez RN, Nogal-Ruiz JJ, Bolas-Fernández F, Martínez-Fernández AR, Gárate T. Identification of Spanish Trichinella isolates by ISSR-PCR: intra-specific variability of Trichinella britovi. Vet Parasitol. 2009 Feb 23;159(3-4):206-9. doi: 10.1016/j.vetpar.2008.10.062. Epub 2008 Oct 22. PubMed PMID: 19046813.