Gastrin hexapeptide

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MedKoo CAT#: 597715

CAS#: 20994-88-1

Description: Gastrin hexapeptide is a hexapeptide from porcine antral mucosa.

Chemical Structure

Gastrin hexapeptide
CAS# 20994-88-1

Theoretical Analysis

MedKoo Cat#: 597715
Name: Gastrin hexapeptide
CAS#: 20994-88-1
Chemical Formula: C40H48N8O9S
Exact Mass: 816.3265
Molecular Weight: 816.93
Elemental Analysis: C, 58.81; H, 5.92; N, 13.72; O, 17.63; S, 3.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Gastrin hexapeptide; Tyr-gly-trp-met-asp-phe-NH2; Gastrin C-terminal hexapeptide;

IUPAC/Chemical Name: (3S,6S,9S,15S)-9-((1H-indol-3-yl)methyl)-15-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-16-(4-hydroxyphenyl)-6-(2-(methylthio)ethyl)-5,8,11,14-tetraoxo-4,7,10,13-tetraazahexadecanoic acid


InChi Code: InChI=1S/C40H48N8O9S/c1-58-16-15-30(38(55)48-33(20-35(51)52)40(57)47-31(36(42)53)18-23-7-3-2-4-8-23)46-39(56)32(19-25-21-43-29-10-6-5-9-27(25)29)45-34(50)22-44-37(54)28(41)17-24-11-13-26(49)14-12-24/h2-14,21,28,30-33,43,49H,15-20,22,41H2,1H3,(H2,42,53)(H,44,54)(H,45,50)(H,46,56)(H,47,57)(H,48,55)(H,51,52)/t28-,30-,31-,32-,33-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CC4=CC=C(O)C=C4)N)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 816.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gregory RA, Dockray GJ, Reeve JR Jr, Shively JE, Miller C. Isolation from porcine antral mucosa of a hexapeptide corresponding to the C-terminal sequence of gastrin. Peptides. 1983 May-Jun;4(3):319-23. PubMed PMID: 6634471.

2: Pincus MR, Carty RP, Chen J, Lubowsky J, Avitable M, Shah D, Scheraga HA, Murphy RB. On the biologically active structures of cholecystokinin, little gastrin, and enkephalin in the gastrointestinal system. Proc Natl Acad Sci U S A. 1987 Jul;84(14):4821-5. PubMed PMID: 3037525; PubMed Central PMCID: PMC305197.

3: Copps J, Ahmed S, Murphy RF, Lovas S. Gastrin 1-6 promotes growth of colon cancer cells through non-CCK receptors. Peptides. 2007 Mar;28(3):632-5. Epub 2006 Nov 28. PubMed PMID: 17126952.

4: Pincus MR, Murphy RB, Carty RP, Chen J, Shah D, Scheraga HA. Conformational analysis of possible biologically active (receptor-bound) conformations of peptides derived from cholecystokinin, cerulein and little gastrin and the opiate peptide, Met-enkephalin. Peptides. 1988;9 Suppl 1:145-52. PubMed PMID: 2856638.