Butonate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592125

CAS#: 126-22-7

Description: Butonate is an Anthelmintic drug.

Chemical Structure

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Butonate
CAS# 126-22-7
Instruction

Theoretical Analysis

MedKoo Cat#: 592125
Name: Butonate
CAS#: 126-22-7
Chemical Formula: C8H14Cl3O5P
Exact Mass: 325.96
Molecular Weight: 327.520
Elemental Analysis: C, 29.34; H, 4.31; Cl, 32.47; O, 24.42; P, 9.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Butonate; NSC 17872; NSC-17872; NSC17872

IUPAC/Chemical Name: Butanoic acid, 2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl ester

InChi Key: BKAQXYNWONVOAX-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H14Cl3O5P/c1-4-5-6(12)16-7(8(9,10)11)17(13,14-2)15-3/h7H,4-5H2,1-3H3

SMILES Code: CCCC(OC(P(OC)(OC)=O)C(Cl)(Cl)Cl)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 327.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Quistad GB, Nomura DK, Sparks SE, Segall Y, Casida JE. Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides. Toxicol Lett. 2002 Sep 5;135(1-2):89-93. PubMed PMID: 12243867.

2: Seidel F, Jahn D, Kirst E, Meeser G, Cersovsky H, Frick W. [Current views on the use of organophosphate insecticides for ectoparasitic control in lactating cattle]. Z Gesamte Hyg. 1985 Aug;31(8):470-2. German. PubMed PMID: 4060787.

3: Leĭka ZA. [Chromatographic determination of micro amounts of butonate]. Gig Sanit. 1983 Jan;(1):52-3. Russian. PubMed PMID: 6826070.

4: Braun R, Schöneich J, Weissflog L, Dedek W. Activity of organophosphorus insecticides in bacterial tests for mutagenicity and DNA repair--direct alkylation vs. metabolic activation and breakdown. I. Butonate, vinylbutonate, trichlorfon, dichlorvos, demethyl dichlorvos and demethyl vinylbutonate. Chem Biol Interact. 1982 Apr;39(3):339-50. PubMed PMID: 7074710.

5: Dedek W, Grahl R, Georgi W. [Metabolism of 32P-butonate and formation of vinylbutonate metabolite in warm-blooded animals]. Arch Exp Veterinarmed. 1981;35(2):199-210. German. PubMed PMID: 7247619.

6: Gabrio T, Meeser G, Kirst E, Cersovsky H. [Studies of the Pedix Pe 50 excretion dynamics in milk]. Arch Exp Veterinarmed. 1980;34(5):713-8. German. PubMed PMID: 7458561.

7: Thiemann KG. [Residue behavior of butonate in chicken eggs]. Z Gesamte Hyg. 1979 Jul;25(7):519-21. German. PubMed PMID: 494702.

8: Ackermann H, Beitz H, Dedek W, Grahl K, Rüffle E, Georgi W, Reinhardt R. [Hygienic and toxicologic evaluation of butonate]. Z Gesamte Hyg. 1979 Jul;25(7):512-8. German. PubMed PMID: 494701.

9: Konrad H, Gabro T, Dedek W. [Behavior of selected veterinary preparations during industrial milk processing]. Nahrung. 1977;21(3):247-53. German. PubMed PMID: 404556.

10: Dedek W, Wenzel K, Schwarz H. [In-vitro and in-vivo studies on the percutaneous absorption of systemic P 32-labelled insecticide organophosphorus compounds in cattle]. Arch Exp Veterinarmed. 1975 Dec;29(6):857-68. German. PubMed PMID: 1227427.

11: Drudge JH, Lyons ET, Tolliver SC. Activity of organophosphorus compounds against oral stages of gasterophilus intestinalis and Gasterophilus nasalis. Am J Vet Res. 1975 Mar;36(3):251-3. PubMed PMID: 1115423.

12: Voss JL, Hibler CP. Critical tests of an orally administered butonate as an anthelmintic in horses. Am J Vet Res. 1973 Sep;34(9):1209-10. PubMed PMID: 4747043.

13: Voss JL, Hibler CP. Critical tests of butonate as an ascaricide and boticide in horses. Am J Vet Res. 1971 Dec;32(12):2085-6. PubMed PMID: 5167171.

14: Dedek W. [Decomposition and residues of 32P-butonate in fruit]. Z Naturforsch B. 1968 Apr;23(4):504-6. German. PubMed PMID: 4386048.

15: Dedek W, Schwarz H. [Studies on the application of the low toxicity 32P- labeled phosphonic acid ester, Butonate, in cattle]. Arch Exp Veterinarmed. 1967;21(4):1023-30. German. PubMed PMID: 5598567.