Vanoxonin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597693

CAS#: 86933-99-5

Description: Vanoxonin is a new inhibitor of thymidylate synthetase.


Price and Availability

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Vanoxonin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597693
Name: Vanoxonin
CAS#: 86933-99-5
Chemical Formula: C18H25N3O9
Exact Mass: 427.1591
Molecular Weight: 427.41
Elemental Analysis: C, 50.58; H, 5.90; N, 9.83; O, 33.69


Synonym: Vanoxonin; Antibiotic MG 245CF2A; MG-245-CF2-A;

IUPAC/Chemical Name: (S)-2-((2S,3R)-2-(2,3-dihydroxybenzamido)-3-hydroxybutanamido)-5-(N-hydroxyacetamido)pentanoic acid

InChi Key: KCWDMHXDGAWLOA-LQJRIPTKSA-N

InChi Code: InChI=1S/C18H25N3O9/c1-9(22)14(20-16(26)11-5-3-7-13(24)15(11)25)17(27)19-12(18(28)29)6-4-8-21(30)10(2)23/h3,5,7,9,12,14,22,24-25,30H,4,6,8H2,1-2H3,(H,19,27)(H,20,26)(H,28,29)/t9-,12+,14+/m1/s1

SMILES Code: O=C(O)[C@H](CCCN(C(C)=O)O)NC([C@H]([C@H](O)C)NC(C1=CC=CC(O)=C1O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Kanai F, Isshiki K, Umezawa Y, Morishima H, Naganawa H, Takita T, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate synthetase. II. Structure determination and total synthesis. J Antibiot (Tokyo). 1985 Jan;38(1):31-8. PubMed PMID: 3972726.

2: Kanai F, Sawa T, Hamada M, Naganawa H, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate synthetase. J Antibiot (Tokyo). 1983 Jun;36(6):656-60. PubMed PMID: 6874588.

3: Kanai F, Kaneko T, Morishima H, Isshiki K, Takita T, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex. J Antibiot (Tokyo). 1985 Jan;38(1):39-50. PubMed PMID: 3972727.