Octicidine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597689

CAS#: 65370-68-5

Description: Octicidine is derived from phaseolotoxin by removal of C-terminal dipeptide; a transition state analog that irreversibly inhibits ornithine carbamoyltransferase.


Chemical Structure

img
Octicidine
CAS# 65370-68-5

Theoretical Analysis

MedKoo Cat#: 597689
Name: Octicidine
CAS#: 65370-68-5
Chemical Formula: C5H14N3O7PS
Exact Mass: 291.03
Molecular Weight: 291.210
Elemental Analysis: C, 20.62; H, 4.85; N, 14.43; O, 38.46; P, 10.64; S, 11.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Octicidine; ASOHO;

IUPAC/Chemical Name: (2S)-2-amino-5-((hydroxy(sulfamoyloxy)phosphoryl)amino)pentanoic acid

InChi Key: LNALGAKWYMMOEZ-BYPYZUCNSA-N

InChi Code: InChI=1S/C5H14N3O7PS/c6-4(5(9)10)2-1-3-8-16(11,12)15-17(7,13)14/h4H,1-3,6H2,(H,9,10)(H2,7,13,14)(H2,8,11,12)/t4-/m0/s1

SMILES Code: N[C@@H](CCCNP(O)(OS(=O)(N)=O)=O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 291.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hatziloukas E, Panopoulos NJ. Origin, structure, and regulation of argK, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase in Pseudomonas syringae pv. phaseolicola, and functional expression of argK in transgenic tobacco. J Bacteriol. 1992 Sep;174(18):5895-909. PubMed PMID: 1522066; PubMed Central PMCID: PMC207126.

2: Langley DB, Templeton MD, Fields BA, Mitchell RE, Collyer CA. Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism. J Biol Chem. 2000 Jun 30;275(26):20012-9. Erratum in: J Biol Chem 2000 Sep 29;275(39):30746. PubMed PMID: 10747936.

3: Templeton MD, Reinhardt LA, Collyer CA, Mitchell RE, Cleland WW. Kinetic analysis of the L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-N delta-(N'-sulfodiaminophosphinyl)-L-ornithine. Biochemistry. 2005 Mar 22;44(11):4408-15. PubMed PMID: 15766270.

4: Templeton MD, Mitchell RE, Sullivan PA, Shepherd MG. The inactivation of ornithine transcarbamoylase by N delta-(N'-sulpho-diaminophosphinyl)-L-ornithine. Biochem J. 1985 Jun 1;228(2):347-52. PubMed PMID: 4015624; PubMed Central PMCID: PMC1144992.