DANP

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MedKoo CAT#: 563243

CAS#: 761401-89-2

Description: DANP is a bulge base recognition probe. It is a strong and specific ligand of the single cytosine and thymine bulges with exclusively 1:1 stoichiometry..


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

DANP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563243
Name: DANP
CAS#: 761401-89-2
Chemical Formula: C14H22N6
Exact Mass: 274.1906
Molecular Weight: 274.37
Elemental Analysis: C, 61.29; H, 8.08; N, 30.63


Synonym: DANP;

IUPAC/Chemical Name: N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine

InChi Key: NKZWHPWGLZLGMH-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H22N6/c15-7-1-9-17-12-5-3-11-4-6-13(18-10-2-8-16)20-14(11)19-12/h3-6H,1-2,7-10,15-16H2,(H2,17,18,19,20)

SMILES Code: NCCCNC1=NC2=NC(NCCCN)=CC=C2C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

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8: Chen H, Parimelalagan M, Takei F, Hapuarachchi HC, Koay ES, Ng LC, Ho PS, Nakatani K, Chu JJ. Development of 2, 7-Diamino-1, 8-Naphthyridine (DANP) Anchored Hairpin Primers for RT-PCR Detection of Chikungunya Virus Infection. PLoS Negl Trop Dis. 2016 Aug 29;10(8):e0004887. doi: 10.1371/journal.pntd.0004887. eCollection 2016 Aug. PubMed PMID: 27571201; PubMed Central PMCID: PMC5003370.

9: Kumar Verma R, Takei F, Nakatani K. Synthesis and Photophysical Properties of Fluorescence Molecular Probe for Turn-ON-Type Detection of Cytosine Bulge DNA. Org Lett. 2016 Jul 1;18(13):3170-3. doi: 10.1021/acs.orglett.6b01378. Epub 2016 Jun 14. PubMed PMID: 27300443.

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12: Wu L, Xu G, Wang X. Identifying critical factors influencing the disposal of dead pigs by farmers in China. Environ Sci Pollut Res Int. 2016 Jan;23(1):661-72. doi: 10.1007/s11356-015-5284-y. Epub 2015 Sep 2. PubMed PMID: 26330314.

13: Cheng S, Wang W, Zhou Q, Chen C, Peng L, Hua L, Li Y, Hou K, Li H. Fast Switching of CO3(-)(H2O)n and O2(-)(H2O)n reactant ions in dopant-assisted negative photoionization ion mobility spectrometry for explosives detection. Anal Chem. 2014 Mar 4;86(5):2687-93. doi: 10.1021/ac404067z. Epub 2014 Feb 11. PubMed PMID: 24484058.

14: Yang J, Wang F, Zhang J, Wang G, Gong X. A theoretical study on 1,5-diazido-3-nitrazapentane (DANP) and 1,7-diazido-2,4,6-trinitrazaheptane (DATNH): molecular and crystal structures, thermodynamic and detonation properties, and pyrolysis mechanism. J Mol Model. 2013 Dec;19(12):5367-76. doi: 10.1007/s00894-013-2014-6. Epub 2013 Oct 27. PubMed PMID: 24162066.

15: Chen H, Takei F, Koay ES, Nakatani K, Chu JJ. A novel DANP-coupled hairpin RT-PCR for rapid detection of Chikungunya virus. J Mol Diagn. 2013 Mar;15(2):227-33. doi: 10.1016/j.jmoldx.2012.10.004. Epub 2013 Jan 9. PubMed PMID: 23313361.

16: Cheng S, Dou J, Wang W, Chen C, Hua L, Zhou Q, Hou K, Li J, Li H. Dopant-assisted negative photoionization ion mobility spectrometry for sensitive detection of explosives. Anal Chem. 2013 Jan 2;85(1):319-26. doi: 10.1021/ac302836f. Epub 2012 Dec 14. PubMed PMID: 23199155.

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18: Kobori A, Mori T, Yamayoshi A, Murakami A. Synthesis of naphthyridine-conjugated DNA probes and their application to SNPs typing. Nucleic Acids Symp Ser (Oxf). 2007;(51):309-10. PubMed PMID: 18029710.

19: Zhang J, Takei F, Nakatani K. Emission of characteristic fluorescence from the ligand-cytosine complex in U_A/ACU bulged RNA duplex. Bioorg Med Chem. 2007 Jul 15;15(14):4813-7. Epub 2007 May 6. PubMed PMID: 17513115.

20: Takei F, Suda H, Hagihara M, Zhang J, Kobori A, Nakatani K. Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA. Chemistry. 2007;13(16):4452-7. PubMed PMID: 17352435.