Ketohypoglycin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558373

CAS#: 5746-24-7

Description: Ketohypoglycin has been used to study the inhibition of gluconeogenesis in isolated rat liver cells.

Chemical Structure

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Ketohypoglycin
CAS# 5746-24-7
Instruction

Theoretical Analysis

MedKoo Cat#: 558373
Name: Ketohypoglycin
CAS#: 5746-24-7
Chemical Formula: C7H8O3
Exact Mass: 140.05
Molecular Weight: 140.140
Elemental Analysis: C, 60.00; H, 5.75; O, 34.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ketohypoglycin; Methylenecyclopropylpyruvate;

IUPAC/Chemical Name: 2-Methylene-alpha-oxocyclopropanepropanoic acid

InChi Key: IKTGVEIOCJLOFU-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H8O3/c1-4-2-5(4)3-6(8)7(9)10/h5H,1-3H2,(H,9,10)

SMILES Code: O=C(O)C(CC1C(C1)=C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 140.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kean EA, Pogson CI. Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin). Biochem J. 1979 Sep 15;182(3):789-96. PubMed PMID: 518564; PubMed Central PMCID: PMC1161413.

2: Marusich JA, Grant KR, Blough BE, Wiley JL. Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice. Neurotoxicology. 2012 Oct;33(5):1305-13. doi: 10.1016/j.neuro.2012.08.003. Epub 2012 Aug 23. PubMed PMID: 22922498; PubMed Central PMCID: PMC3475178.

3: Kler RS, Sherratt HS, Turnbull DM. The measurement of mitochondrial beta-oxidation by release of 3H2O from [9,10-3H]hexadecanoate: application to skeletal muscle and the use of inhibitors as models of metabolic disease. Biochem Med Metab Biol. 1992 Apr;47(2):145-56. PubMed PMID: 1515172.

4: Billington D, Sherratt HS. Hypoglycin and metabolically related inhibitors. Methods Enzymol. 1981;72:610-6. PubMed PMID: 7311858.