Farnesylthiotriazole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563220

CAS#: 156604-45-4

Description: Farnesylthiotriazole is a persistent PKC activator.

Chemical Structure

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Farnesylthiotriazole
CAS# 156604-45-4
Instruction

Theoretical Analysis

MedKoo Cat#: 563220
Name: Farnesylthiotriazole
CAS#: 156604-45-4
Chemical Formula: C17H27N3S
Exact Mass: 305.19
Molecular Weight: 305.480
Elemental Analysis: C, 66.84; H, 8.91; N, 13.76; S, 10.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Farnesylthiotriazole;

IUPAC/Chemical Name: 5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanyl-1H-1,2,4-triazole

InChi Key: QFXNCKFWHATRCH-XGGJEREUSA-N

InChi Code: InChI=1S/C17H27N3S/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-21-17-18-13-19-20-17/h7,9,11,13H,5-6,8,10,12H2,1-4H3,(H,18,19,20)/b15-9+,16-11+

SMILES Code: C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC1=NC=NN1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 305.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lamango NS, Ayuk-Takem LT, Nesby R, Zhao WQ, Charlton CG. Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs. Pharmacol Biochem Behav. 2003 Dec;76(3-4):433-42. PubMed PMID: 14643842.

2: Meinhardt G, Eppinger E, Schmidmaier R. Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. Anticancer Drugs. 2002 Aug;13(7):725-33. PubMed PMID: 12187329.

3: Weissmann N, Voswinckel R, Hardebusch T, Rosseau S, Ghofrani HA, Schermuly R, Seeger W, Grimminger F. Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction. Am J Physiol. 1999 Jan;276(1 Pt 1):L90-5. PubMed PMID: 9887060.

4: Gilbert BA, Lim YH, Ding J, Badwey JA, Rando RR. Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. Biochemistry. 1995 Mar 28;34(12):3916-20. PubMed PMID: 7696255.