N 556

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597508

CAS#: 110816-78-9

Description: N 556 is a prodrug for disodium cromoglycate.

Chemical Structure

N 556
CAS# 110816-78-9

Theoretical Analysis

MedKoo Cat#: 597508
Name: N 556
CAS#: 110816-78-9
Chemical Formula: C33H38Cl2N2O12
Exact Mass:
Molecular Weight: 725.56
Elemental Analysis: C, 54.63; H, 5.28; Cl, 9.77; N, 3.86; O, 26.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: N 556; N-556; N556; KY-556; KY556;

IUPAC/Chemical Name: diethyl 5,5'-((2-((2,6-diaminohexanoyl)oxy)propane-1,3-diyl)bis(oxy))(S)-bis(4-oxo-4H-chromene-2-carboxylate) dihydrochloride


InChi Code: InChI=1S/C33H36N2O12.2ClH/c1-3-41-32(39)27-15-21(36)29-23(10-7-12-25(29)46-27)43-17-19(45-31(38)20(35)9-5-6-14-34)18-44-24-11-8-13-26-30(24)22(37)16-28(47-26)33(40)42-4-2;;/h7-8,10-13,15-16,19-20H,3-6,9,14,17-18,34-35H2,1-2H3;2*1H/t20-;;/m0../s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 725.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Yoshimi A, Hashizume H, Kitagawa M, Nishimura K, Kakeya N. Absorption mechanism of 1,3-bis(2-ethoxycarbonylchromon-5-yloxy)-2-((S)-lysyloxy )propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate. Biol Pharm Bull. 1993 Apr;16(4):375-8. PubMed PMID: 8358388.

2: Yoshimi A, Hashizume H, Kitagawa M, Nishimura K, Kakeya N. Characteristics of 1,3-bis-(2-ethoxycarbonylchromon-5-yloxy)-2-((S)- lysyloxy)propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate, in absorption and excretion in rats and rabbits. J Pharmacobiodyn. 1992 Dec;15(12):681-6. PubMed PMID: 1296978.

3: Nakamura S, Yamamura H, Kohno S, Ohata K, Yoshimi A, Nishimura K, Kakeya N. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8. PubMed PMID: 2096808.

4: Nagai H, Yamaguchi S, Maeda Y, Tanaka H. Role of mast cells, eosinophils and IL-5 in the development of airway hyperresponsiveness in sensitized mice. Clin Exp Allergy. 1996 Jun;26(6):642-7. PubMed PMID: 8809421.