p2Ca Peptide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597471

CAS#: 142606-55-1

Description: p2Ca Peptide is a self-peptide derived from the enzyme alpha-ketoglutarate dehydrogenase.


Price and Availability

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p2Ca Peptide is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597471
Name: p2Ca Peptide
CAS#: 142606-55-1
Chemical Formula: C47H66N8O12
Exact Mass: 934.48
Molecular Weight: 935.08
Elemental Analysis: C, 60.37; H, 7.11; N, 11.98; O, 20.53


Synonym: p2Ca Peptide; Lspfpfdl; p2Ca-Y4;

IUPAC/Chemical Name: L-leucyl-L-seryl-L-prolyl-L-phenylalanyl-L-prolyl-L-phenylalanyl-L-aspartyl-L-leucine

InChi Key: RLTLDVPHEYUGFZ-QSVFAHTRSA-N

InChi Code: InChI=1S/C47H66N8O12/c1-27(2)21-31(48)40(59)53-36(26-56)46(65)55-20-12-18-38(55)44(63)51-34(24-30-15-9-6-10-16-30)45(64)54-19-11-17-37(54)43(62)50-32(23-29-13-7-5-8-14-29)41(60)49-33(25-39(57)58)42(61)52-35(47(66)67)22-28(3)4/h5-10,13-16,27-28,31-38,56H,11-12,17-26,48H2,1-4H3,(H,49,60)(H,50,62)(H,51,63)(H,52,61)(H,53,59)(H,57,58)(H,66,67)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1

SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H]2N(C([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H](CO)NC([C@H](CC(C)C)N)=O)=O)CCC4)=O)=O)CCC2)=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Hornell TM, Martin SM, Myers NB, Connolly JM. Peptide length variants p2Ca and QL9 present distinct conformations to L(d)-specific T cells. J Immunol. 2001 Oct 15;167(8):4207-14. PubMed PMID: 11591741.

2: Dutz JP, Tsomides TJ, Kageyama S, Rasmussen MH, Eisen HN. A cytotoxic T lymphocyte clone can recognize the same naturally occurring self peptide in association with a self and nonself class I MHC protein. Mol Immunol. 1994 Sep;31(13):967-75. PubMed PMID: 8084337.

3: Wada H, Ono T, Uenaka A, Monden M, Nakayama E. Requirement of CD4+ T cells and antigen-presenting cells for primary in vitro generation of CD8+ cytotoxic T cells against Ld-binding self-peptide p2Ca. Immunology. 1995 Apr;84(4):633-7. PubMed PMID: 7790038; PubMed Central PMCID: PMC1415149.

4: Tjoa BA, Kranz DM. Sequence restrictions in T cell receptor beta-chains that have specificity for a self-peptide/Ld complex. Mol Immunol. 1994 Jul;31(10):705-11. PubMed PMID: 7518567.

5: Wu MX, Tsomides TJ, Eisen HN. Tissue distribution of natural peptides derived from a ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions. J Immunol. 1995 May 1;154(9):4495-502. PubMed PMID: 7536771.

6: Holler PD, Lim AR, Cho BK, Rund LA, Kranz DM. CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation. J Exp Med. 2001 Oct 15;194(8):1043-52. PubMed PMID: 11602635; PubMed Central PMCID: PMC2193521.

7: Goldstein J, Mostowsky H, Tung J, Hon H, Brunswick M, Kozlowski S. Naive alloreactive CD8 T cells are activated by purified major histocompatibility complex class I and antigenic peptide. Eur J Immunol. 1997 Apr;27(4):871-8. PubMed PMID: 9130638.

8: Jones LL, Colf LA, Stone JD, Garcia KC, Kranz DM. Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. J Immunol. 2008 Nov 1;181(9):6255-64. PubMed PMID: 18941216; PubMed Central PMCID: PMC2598777.

9: Rivas FV, O'Herrin S, Gajewski TF. CD28 is not required for c-Jun N-terminal kinase activation in T cells. J Immunol. 2001 Sep 15;167(6):3123-8. PubMed PMID: 11544297.

10: Pawlowski TJ, Singleton MD, Loh DY, Berg R, Staerz UD. Permissive recognition during positive selection. Eur J Immunol. 1996 Apr;26(4):851-7. PubMed PMID: 8625978.