Jmv 390-1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597443

CAS#: 148473-36-3

Description: Jmv 390-1 is a metallopeptidase inhibitor.


Chemical Structure

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Jmv 390-1
CAS# 148473-36-3

Theoretical Analysis

MedKoo Cat#: 597443
Name: Jmv 390-1
CAS#: 148473-36-3
Chemical Formula: C23H35N3O6
Exact Mass: 449.2526
Molecular Weight: 449.54
Elemental Analysis: C, 61.45; H, 7.85; N, 9.35; O, 21.35

Price and Availability

Size Price Availability Quantity
1.0mg USD 300.0 2 Weeks
2.0mg USD 495.0 2 Weeks
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Synonym: Jmv 390-1; Jmv-390-1; Jmv390-1;

IUPAC/Chemical Name: ((R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl)-L-isoleucyl-L-leucine

InChi Key: MWZOULASPWUGJJ-NFBUACBFSA-N

InChi Code: InChI=1S/C23H35N3O6/c1-5-15(4)20(22(29)24-18(23(30)31)11-14(2)3)25-21(28)17(13-19(27)26-32)12-16-9-7-6-8-10-16/h6-10,14-15,17-18,20,32H,5,11-13H2,1-4H3,(H,24,29)(H,25,28)(H,26,27)(H,30,31)/t15-,17+,18-,20-/m0/s1

SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=CC=C1)CC(NO)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 449.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kitabgi P, Dubuc I, Nouel D, Costentin J, Cuber JC, Fulcrand H, Doulut S, Rodriguez M, Martinez J. Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus. Neurosci Lett. 1992 Aug 17;142(2):200-4. PubMed PMID: 1454216.

2: Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC. Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem. 2014 Jul;130(2):313-23. doi: 10.1111/jnc.12720. Epub 2014 Apr 19. PubMed PMID: 24661079; PubMed Central PMCID: PMC4137327.

3: Cruz-Diaz N, Wilson BA, Pirro NT, Brosnihan KB, Marshall AC, Chappell MC. Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells. Peptides. 2016 Sep;83:29-37. doi: 10.1016/j.peptides.2016.06.005. Epub 2016 Jun 15. PubMed PMID: 27315786; PubMed Central PMCID: PMC5500233.

4: Yilmaz EM, Güntert P. NMR structure calculation for all small molecule ligands and non-standard residues from the PDB Chemical Component Dictionary. J Biomol NMR. 2015 Sep;63(1):21-37. doi: 10.1007/s10858-015-9959-y. Epub 2015 Jun 30. PubMed PMID: 26123317.

5: Doulut S, Dubuc I, Rodriguez M, Vecchini F, Fulcrand H, Barelli H, Checler F, Bourdel E, Aumelas A, Lallement JC, et al. Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J Med Chem. 1993 May 14;36(10):1369-79. PubMed PMID: 8496905.