Kentsin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558339

CAS#: 56767-30-7

Description: Kentsin is a contraceptive polypeptide that has central opiate properties on gastrointestinal motility.

Chemical Structure

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Kentsin
CAS# 56767-30-7
Instruction

Theoretical Analysis

MedKoo Cat#: 558339
Name: Kentsin
CAS#: 56767-30-7
Chemical Formula: C21H40N8O6
Exact Mass: 500.31
Molecular Weight: 500.600
Elemental Analysis: C, 50.39; H, 8.05; N, 22.38; O, 19.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Kentsin;

IUPAC/Chemical Name: N(2)-(N(2)-(1-L-Threonyl-L-prolyl)-L-arginyl)-L-lysine

InChi Key: OTAMFXXAGYBAQL-YXMSTPNBSA-N

InChi Code: InChI=1S/C21H40N8O6/c1-12(30)16(23)19(33)29-11-5-8-15(29)18(32)27-13(7-4-10-26-21(24)25)17(31)28-14(20(34)35)6-2-3-9-22/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13+,14+,15+,16+/m1/s1

SMILES Code: NCCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]1N(C([C@H]([C@H](O)C)N)=O)CCC1)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 500.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fox DA, Ayres EA, Wire WS, Lui G, Yamamura HI, Burks TF. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Peptides. 1987 Jul-Aug;8(4):613-8. PubMed PMID: 2819832.

2: Messiha FS. Enkephalins, their constituents and voluntary drinking of ethanol by the rat. Physiol Behav. 1989 Jul;46(1):29-33. PubMed PMID: 2813554.

3: Bueno L, Fioramonti J, Menezo Y. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Eur J Pharmacol. 1985 Aug 7;114(1):67-70. PubMed PMID: 4043221.

4: Wieczorek Z, Zimecki M, Słoń JJ, Siemion IZ. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994;15(2):215-21. PubMed PMID: 8008626.

5: Suk WA, Long CW. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin. J Gen Virol. 1981 Jan;52(Pt 1):189-94. PubMed PMID: 6167663.

6: Goldman R, Bar-Shavit Z. On the mechanism of the augmentation of the phagocytic capability of phagocytic cells by Tuftsin, substance P, neurotensin, and kentsin and the interrelationship between their receptors. Ann N Y Acad Sci. 1983;419:143-55. Review. PubMed PMID: 6201115.

7: Buéno L, Fargeas MJ, Fioramonti J, Menezo Y. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci. 1986 Jul 14;39(2):141-6. PubMed PMID: 3014251.

8: Rusu I, Yaron A. Aminopeptidase P from human leukocytes. Eur J Biochem. 1992 Nov 15;210(1):93-100. PubMed PMID: 1446689.

9: Siemion IZ, Kluczyk A, Słoń JJ, Zimecki M, Wieczorek Z. Immunosuppressive activity of analogs of tripeptide Lys-Arg-Pro with D-amino acid residues. Arch Immunol Ther Exp (Warsz). 1994;42(3):205-7. PubMed PMID: 7487354.

10: Cupo A, Menezo Y, Bueno L. Enkephalin production by the corpus luteum. Neuropeptides. 1987 Apr;9(3):237-45. PubMed PMID: 3601012.

11: Najjar VA, Konopinska D, Chaudhuri MK, Schmidt DE, Linehan L. Tuftsin, a natural activator of phagocytic functions including tumoricidal activity. Mol Cell Biochem. 1981 Dec 4;41:3-12. PubMed PMID: 6895774.

12: Püschel G, Mentlein R, Heymann E. Isolation and characterization of dipeptidyl peptidase IV from human placenta. Eur J Biochem. 1982 Aug;126(2):359-65. PubMed PMID: 6751824.

13: Liu H, Krull IS, Cohen SA. Femtomole peptide mapping by derivatization, high-performance liquid chromatography, and fluorescence detection. Anal Biochem. 2001 Jul 1;294(1):7-18. PubMed PMID: 11412000.