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MedKoo CAT#: 563160

CAS#: 200933-14-8

Description: m-3M3FBS is an activator of phospholipase C (PLC). It acts by stimulating superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 250 2 Weeks
25mg USD 460 2 Weeks
50mg USD 760 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-11. Prices are subject to change without notice.

m-3M3FBS, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 563160
Name: m-3M3FBS
CAS#: 200933-14-8
Chemical Formula: C16H16F3NO2S
Exact Mass: 343.0854
Molecular Weight: 343.36
Elemental Analysis: C, 55.97; H, 4.70; F, 16.60; N, 4.08; O, 9.32; S, 9.34

Synonym: m-3M3FBS; m 3M3FBS; m3M3FBS;

IUPAC/Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide


InChi Code: InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

SMILES Code: O=S(C1=C(C)C=C(C)C=C1C)(NC2=CC=CC(C(F)(F)F)=C2)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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4: Sturgeon RM, Magoski NS. Diacylglycerol-mediated regulation of Aplysia bag cell neuron excitability requires protein kinase C. J Physiol. 2016 Oct 1;594(19):5573-92. doi: 10.1113/JP272152. Epub 2016 Jun 30. PubMed PMID: 27198498; PubMed Central PMCID: PMC5043051.

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6: Yang H, Xu S, Li J, Wang L, Wang X. Potassium 2-(1-hydroxypentyl)-benzoate inhibits ADP-induced rat platelet aggregation through P2Y1-PLC signaling pathways. Naunyn Schmiedebergs Arch Pharmacol. 2015 Sep;388(9):983-90. doi: 10.1007/s00210-015-1113-6. Epub 2015 Mar 19. PubMed PMID: 25787305.

7: Szebenyi SA, Ogura T, Sathyanesan A, AlMatrouk AK, Chang J, Lin W. Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. Front Cell Neurosci. 2014 Oct 21;8:336. doi: 10.3389/fncel.2014.00336. eCollection 2014. PubMed PMID: 25374507; PubMed Central PMCID: PMC4204526.

8: Al-Momany A, Li L, Alexander RT, Ballermann BJ. Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A. J Cell Sci. 2014 Dec 15;127(Pt 24):5164-78. doi: 10.1242/jcs.147744. Epub 2014 Oct 24. PubMed PMID: 25344252.

9: Chen WC, Chou CT, Liou WC, Liu SI, Lin KL, Lu T, Lu YC, Hsu SS, Tsai JY, Liao WC, Liang WZ, Jan CR. Rise of [Ca²⁺]i and apoptosis induced by M-3M3FBS in SCM1 human gastric cancer cells. Chin J Physiol. 2014 Feb 28;57(1):31-40. doi: 10.4077/CJP.2014.BAB141. PubMed PMID: 24621336.

10: Semple-Rowland S, Madorsky I, Bolch S, Berry J, Smith WC. Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One. 2013 Dec 26;8(12):e83378. doi: 10.1371/journal.pone.0083378. eCollection 2013. PubMed PMID: 24386190; PubMed Central PMCID: PMC3873303.

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14: Liu SI, Lin KL, Lu T, Lu YC, Hsu SS, Tsai JY, Liao WC, Huang FD, Chi CC, Liang WZ, Tseng LL, Chiang AJ, Jan CR. M-3M3FBS-induced Ca² ⁺ movement and apoptosis in HA59T human hepatoma cells. Chin J Physiol. 2013 Feb 28;56(1):26-35. doi: 10.4077/CJP.2013.BAA091. PubMed PMID: 23347013.

15: Kim SD, Kim HJ, Shim JW, Lee HY, Lee SK, Kwon S, Jung YS, Baek SH, Park JS, Zabel BA, Bae YS. Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. J Immunol. 2012 Aug 15;189(4):2000-5. doi: 10.4049/jimmunol.1200635. Epub 2012 Jul 13. PubMed PMID: 22798676.

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19: Tsai JY, Shieh P, Kuo DH, Chen FA, Kuo CC, Jan CR. Effect of m-3M3FBS on Ca²⁺ movement in PC3 human prostate cancer cells. Chin J Physiol. 2010 Jun 30;53(3):151-9. PubMed PMID: 21793323.

20: Kang YH, Shin HM. Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca Influx and Ca Release in Rat Aorta. Evid Based Complement Alternat Med. 2012;2012:513068. doi: 10.1155/2012/513068. Epub 2011 Jul 13. PubMed PMID: 21785647; PubMed Central PMCID: PMC3137977.