m-3M3FBS
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MedKoo CAT#: 563160

CAS#: 200933-14-8

Description: m-3M3FBS is an activator of phospholipase C (PLC). It acts by stimulating superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 250 2 Weeks
25mg USD 460 2 Weeks
50mg USD 760 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-11. Prices are subject to change without notice.

m-3M3FBS, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563160
Name: m-3M3FBS
CAS#: 200933-14-8
Chemical Formula: C16H16F3NO2S
Exact Mass: 343.0854
Molecular Weight: 343.36
Elemental Analysis: C, 55.97; H, 4.70; F, 16.60; N, 4.08; O, 9.32; S, 9.34


Synonym: m-3M3FBS; m 3M3FBS; m3M3FBS;

IUPAC/Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide

InChi Key: ZIIUUSVHCHPIQD-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

SMILES Code: O=S(C1=C(C)C=C(C)C=C1C)(NC2=CC=CC(C(F)(F)F)=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Wang Y, Tu L, Li Y, Chen D, Liu Z, Hu X, Wang S. Notoginsenoside R1 Alleviates Oxygen-Glucose Deprivation/Reoxygenation Injury by Suppressing Endoplasmic Reticulum Calcium Release via PLC. Sci Rep. 2017 Nov 24;7(1):16226. doi: 10.1038/s41598-017-16373-7. PubMed PMID: 29176553; PubMed Central PMCID: PMC5701215.

2: Grześk E, Szadujkis-Szadurska K, Bloch-Bogusławska E, Wiciński M, Malinowski B, KołTan S, Tejza B, Pujanek M, GrześK G. 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide increases calcium influx in lipopolisaccharide-pre-treated arteries. Exp Ther Med. 2017 Feb;13(2):766-770. doi: 10.3892/etm.2016.3986. Epub 2016 Dec 19. PubMed PMID: 28352364; PubMed Central PMCID: PMC5348699.

3: Fukuda T, Kuroda T, Kono M, Hyoguchi M, Tajiri S, Tanaka M, Mine Y, Matsui T. Adenine attenuates the Ca(2+) contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Sep;389(9):999-1007. doi: 10.1007/s00210-016-1264-0. Epub 2016 Jun 18. PubMed PMID: 27318925.

4: Sturgeon RM, Magoski NS. Diacylglycerol-mediated regulation of Aplysia bag cell neuron excitability requires protein kinase C. J Physiol. 2016 Oct 1;594(19):5573-92. doi: 10.1113/JP272152. Epub 2016 Jun 30. PubMed PMID: 27198498; PubMed Central PMCID: PMC5043051.

5: Grześk E, Szadujkis-Szadurska K, Wiciński M, Malinowski B, Sinjab TA, Tejza B, Pujanek M, Janiszewska E, Kopczyńska A, Grześk G. Effect of 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-sulfonamide on calcium influx in three contraction models. Biomed Rep. 2016 Jan;4(1):117-121. Epub 2015 Nov 10. PubMed PMID: 26870347; PubMed Central PMCID: PMC4726898.

6: Yang H, Xu S, Li J, Wang L, Wang X. Potassium 2-(1-hydroxypentyl)-benzoate inhibits ADP-induced rat platelet aggregation through P2Y1-PLC signaling pathways. Naunyn Schmiedebergs Arch Pharmacol. 2015 Sep;388(9):983-90. doi: 10.1007/s00210-015-1113-6. Epub 2015 Mar 19. PubMed PMID: 25787305.

7: Szebenyi SA, Ogura T, Sathyanesan A, AlMatrouk AK, Chang J, Lin W. Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. Front Cell Neurosci. 2014 Oct 21;8:336. doi: 10.3389/fncel.2014.00336. eCollection 2014. PubMed PMID: 25374507; PubMed Central PMCID: PMC4204526.

8: Al-Momany A, Li L, Alexander RT, Ballermann BJ. Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A. J Cell Sci. 2014 Dec 15;127(Pt 24):5164-78. doi: 10.1242/jcs.147744. Epub 2014 Oct 24. PubMed PMID: 25344252.

9: Chen WC, Chou CT, Liou WC, Liu SI, Lin KL, Lu T, Lu YC, Hsu SS, Tsai JY, Liao WC, Liang WZ, Jan CR. Rise of [Ca²⁺]i and apoptosis induced by M-3M3FBS in SCM1 human gastric cancer cells. Chin J Physiol. 2014 Feb 28;57(1):31-40. doi: 10.4077/CJP.2014.BAB141. PubMed PMID: 24621336.

10: Semple-Rowland S, Madorsky I, Bolch S, Berry J, Smith WC. Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One. 2013 Dec 26;8(12):e83378. doi: 10.1371/journal.pone.0083378. eCollection 2013. PubMed PMID: 24386190; PubMed Central PMCID: PMC3873303.

11: Albarrán L, Dionisio N, López E, Salido GM, Rosado JA. The membrane potential modulates thrombin-stimulated Ca²⁺ mobilization and platelet aggregation. Arch Biochem Biophys. 2013 Oct 15;538(2):130-7. doi: 10.1016/j.abb.2013.08.007. Epub 2013 Aug 27. PubMed PMID: 23988350.

12: Kusaka E, Sugiyama M, Senoo N, Yamamoto A, Sugimoto Y. Genomic and non-genomic effects of glucocorticoids on allergic rhinitis model in mice. Int Immunopharmacol. 2013 Jun;16(2):279-87. doi: 10.1016/j.intimp.2013.03.030. Epub 2013 Apr 10. PubMed PMID: 23583558.

13: Fujita F, Uchida K, Takaishi M, Sokabe T, Tominaga M. Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5-bisphosphate. J Neurosci. 2013 Apr 3;33(14):6154-9. doi: 10.1523/JNEUROSCI.5672-12.2013. PubMed PMID: 23554496.

14: Liu SI, Lin KL, Lu T, Lu YC, Hsu SS, Tsai JY, Liao WC, Huang FD, Chi CC, Liang WZ, Tseng LL, Chiang AJ, Jan CR. M-3M3FBS-induced Ca² ⁺ movement and apoptosis in HA59T human hepatoma cells. Chin J Physiol. 2013 Feb 28;56(1):26-35. doi: 10.4077/CJP.2013.BAA091. PubMed PMID: 23347013.

15: Kim SD, Kim HJ, Shim JW, Lee HY, Lee SK, Kwon S, Jung YS, Baek SH, Park JS, Zabel BA, Bae YS. Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. J Immunol. 2012 Aug 15;189(4):2000-5. doi: 10.4049/jimmunol.1200635. Epub 2012 Jul 13. PubMed PMID: 22798676.

16: Chi CC, Chou CT, Kuo CC, Hsieh YD, Liang WZ, Tseng LL, Su HH, Chu ST, Ho CM, Jan CR. Effect of m-3m3FBS on Ca2+ handling and viability in OC2 human oral cancer cells. Acta Physiol Hung. 2012 Mar;99(1):74-86. doi: 10.1556/APhysiol.99.2012.1.8. PubMed PMID: 22425810.

17: Brown RA, Leung E, Kankaanranta H, Moilanen E, Page CP. Effects of heparin and related drugs on neutrophil function. Pulm Pharmacol Ther. 2012 Apr;25(2):185-92. doi: 10.1016/j.pupt.2012.01.006. Epub 2012 Feb 4. PubMed PMID: 22327105.

18: Morita T, Okada M, Hara Y, Yamawaki H. Mechanisms underlying impairment of endothelium-dependent relaxation by fetal bovine serum in organ-cultured rat mesenteric artery. Eur J Pharmacol. 2011 Oct 15;668(3):401-6. doi: 10.1016/j.ejphar.2011.07.040. Epub 2011 Aug 10. PubMed PMID: 21854767.

19: Tsai JY, Shieh P, Kuo DH, Chen FA, Kuo CC, Jan CR. Effect of m-3M3FBS on Ca²⁺ movement in PC3 human prostate cancer cells. Chin J Physiol. 2010 Jun 30;53(3):151-9. PubMed PMID: 21793323.

20: Kang YH, Shin HM. Cinnamomi ramulus Ethanol Extract Exerts Vasorelaxation through Inhibition of Ca Influx and Ca Release in Rat Aorta. Evid Based Complement Alternat Med. 2012;2012:513068. doi: 10.1155/2012/513068. Epub 2011 Jul 13. PubMed PMID: 21785647; PubMed Central PMCID: PMC3137977.