Caprolactam
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591894

CAS#: 105-60-2

Description: Caprolactam is a Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type.


Chemical Structure

img
Caprolactam
CAS# 105-60-2

Theoretical Analysis

MedKoo Cat#: 591894
Name: Caprolactam
CAS#: 105-60-2
Chemical Formula: C6H11NO
Exact Mass: 113.08
Molecular Weight: 113.160
Elemental Analysis: C, 63.69; H, 9.80; N, 12.38; O, 14.14

Price and Availability

Size Price Availability Quantity
25g USD 250 2 Weeks
Bulk inquiry

Synonym: Caprolactam

IUPAC/Chemical Name: 2H-Azepin-2-one, hexahydro-

InChi Key: JBKVHLHDHHXQEQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H11NO/c8-6-4-2-1-3-5-7-6/h1-5H2,(H,7,8)

SMILES Code: O=C1NCCCCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Biological target:
In vitro activity:
In vivo activity: A carcinogenesis bioassay of caprolactam, a chemical intermediate used in the production of nylon 6, was conducted by feeding diets containing 3,750 or 7,500 ppm caprolactam to groups of 50 male or female F344 rats and 7,500 or 15,000 ppm to groups of 50 male or female B6C3F1 mice for 103 weeks. Control groups consisted of 50 undosed rats and 50 undosed mice of each sex. Throughout the bioassay, mean body weight gains for dosed rats and mice of either sex were decreased when compared with those of the controls. No other compound-related effects were observed. Under the conditions of this bioassay, caprolactam was not carcinogenic for F344 rats or B6C3F1 mice. Levels of Evidence of Carcinogenicity: Male Rats: Negative Female Rats: Negative Male Mice: Negative Female Mice: Negative Synonyms: aminocaproic lactam; 2-oxohexamethylenimine Reference: Natl Toxicol Program Tech Rep Ser. 1982 Mar;214:1-129. https://ntp.niehs.nih.gov/go/tr214abs

Preparing Stock Solutions

The following data is based on the product molecular weight 113.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol: 1. National Toxicology Program. Carcinogenesis Bioassay of Caprolactam (CAS No. 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study). Natl Toxicol Program Tech Rep Ser. 1982 Mar;214:1-129. PMID: 12778221.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Grogan G, Frese A, Barrass S, Adams J, Sutton P. An Aminocaprolactam Racemase from Ochrobactrum anthropi with Promiscuous Amino Acid Ester Racemase Activity. Chembiochem. 2018 Jun 13. doi: 10.1002/cbic.201800265. [Epub ahead of print] PubMed PMID: 29897155.

2: Zhang Z, Wang C, Huang G, Liu H, Yang S, Zhang A. Thermal degradation behaviors and reaction mechanism of carbon fibre-epoxy composite from hydrogen tank by TG-FTIR. J Hazard Mater. 2018 May 28;357:73-80. doi: 10.1016/j.jhazmat.2018.05.057. [Epub ahead of print] PubMed PMID: 29864690.

3: Zhao X, Zhan L, Xie B, Gao B. Products derived from waste plastics (PC, HIPS, ABS, PP and PA6) via hydrothermal treatment: Characterization and potential applications. Chemosphere. 2018 Sep;207:742-752. doi: 10.1016/j.chemosphere.2018.05.156. Epub 2018 May 26. PubMed PMID: 29859486.

4: Otzen M, Palacio C, Janssen DB. Characterization of the caprolactam degradation pathway in Pseudomonas jessenii using mass spectrometry-based proteomics. Appl Microbiol Biotechnol. 2018 May 31. doi: 10.1007/s00253-018-9073-7. [Epub ahead of print] PubMed PMID: 29850960.

5: Ono K, Nakamura T, Ebina T, Ishizaki M, Kurihara M. Improvement of the Heat Resistance of Prussian Blue Nanoparticles in a Clay Film Composed of Smectite Clay and ε-Caprolactam. Inorg Chem. 2018 Jun 4;57(11):6214-6217. doi: 10.1021/acs.inorgchem.8b00707. Epub 2018 May 23. PubMed PMID: 29790338.

6: Barmpalexis P, Karagianni A, Kachrimanis K. Molecular simulations for amorphous drug formulation: Polymeric matrix properties relevant to hot-melt extrusion. Eur J Pharm Sci. 2018 Jul 1;119:259-267. doi: 10.1016/j.ejps.2018.04.035. Epub 2018 Apr 24. PubMed PMID: 29702231.

7: Haned Z, Moulay S, Lacorte S. Migration of plasticizers from poly(vinyl chloride) and multilayer infusion bags using selective extraction and GC-MS. J Pharm Biomed Anal. 2018 Jul 15;156:80-87. doi: 10.1016/j.jpba.2018.04.011. Epub 2018 Apr 12. PubMed PMID: 29694937.

8: Miletto I, Ivaldi C, Paul G, Chapman S, Marchese L, Raja R, Gianotti E. Hierarchical SAPO-34 Architectures with Tailored Acid Sites using Sustainable Sugar Templates. ChemistryOpen. 2018 Apr 14;7(4):297-301. doi: 10.1002/open.201800001. eCollection 2018 Apr. PubMed PMID: 29686961; PubMed Central PMCID: PMC5899749.

9: Winderl J, Spies T, Hubbuch J. Packing characteristics of winged shaped polymer fiber supports for preparative chromatography. J Chromatogr A. 2018 Jun 8;1553:67-80. doi: 10.1016/j.chroma.2018.04.020. Epub 2018 Apr 12. PubMed PMID: 29680743.

10: Cheng J, Chen P, Song A, Wang D, Wang Q. Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives. J Ind Microbiol Biotechnol. 2018 Apr 13. doi: 10.1007/s10295-018-2030-8. [Epub ahead of print] Review. PubMed PMID: 29654382.

11: Fu JJ, Liu CC. Tri-block polymer with interfacial layer formation ability and its use in maintaining supersaturated drug solution after dissolution of solid dispersions. Int J Nanomedicine. 2018 Mar 16;13:1611-1619. doi: 10.2147/IJN.S152415. eCollection 2018. PubMed PMID: 29588588; PubMed Central PMCID: PMC5862016.

12: Omer E, Cariou R, Remaud G, Guitton Y, Germon H, Hill P, Dervilly-Pinel G, Le Bizec B. Elucidation of non-intentionally added substances migrating from polyester-polyurethane lacquers using automated LC-HRMS data processing. Anal Bioanal Chem. 2018 Mar 8. doi: 10.1007/s00216-018-0968-z. [Epub ahead of print] PubMed PMID: 29516137.

13: Eudes A, Berthomieu R, Hao Z, Zhao N, Benites VT, Baidoo EEK, Loqué D. Production of muconic acid in plants. Metab Eng. 2018 Mar;46:13-19. doi: 10.1016/j.ymben.2018.02.002. Epub 2018 Feb 21. PubMed PMID: 29474840.

14: Dian LH, Hu YJ, Lin JY, Zhang JY, Yan Y, Cui YN, Su ZB, Lu WL. Fabrication of paclitaxel hybrid nanomicelles to treat resistant breast cancer via oral administration. Int J Nanomedicine. 2018 Feb 2;13:719-731. doi: 10.2147/IJN.S150140. eCollection 2018. PubMed PMID: 29440897; PubMed Central PMCID: PMC5799853.

15: Reshma SV, Sathyanarayanan N, Nagendra HG. Characterization of a hypothetical protein YVRE from Bacillus subtilis indicates its key role as glucono-lactonase in pentose phosphate pathway and glucose metabolism. Bioinformation. 2017 Dec 31;13(12):430-438. doi: 10.6026/97320630013430. eCollection 2017. PubMed PMID: 29379263; PubMed Central PMCID: PMC5767921.

16: Pinto JMO, Leão AF, Riekes MK, França MT, Stulzer HK. HPMCAS as an effective precipitation inhibitor in amorphous solid dispersions of the poorly soluble drug candesartan cilexetil. Carbohydr Polym. 2018 Mar 15;184:199-206. doi: 10.1016/j.carbpol.2017.12.052. Epub 2017 Dec 24. PubMed PMID: 29352911.

17: Chugaev DV, Kornilov NN, Lasunskii SA. [Bidirectional knotless barbed sutures during primary total knee arthroplasty: effective solution or new problem?]. Khirurgiia (Mosk). 2017;(12):58-65. doi: 10.17116/hirurgia20171258-65. Russian. PubMed PMID: 29286032.

18: Quan G, Niu B, Singh V, Zhou Y, Wu CY, Pan X, Wu C. Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement. Int J Nanomedicine. 2017 Dec 13;12:8801-8811. doi: 10.2147/IJN.S149717. eCollection 2017. PubMed PMID: 29263669; PubMed Central PMCID: PMC5732552.

19: Morales LT, González-García LN, Orozco MC, Restrepo S, Vives MJ. The genomic study of an environmental isolate of Scedosporium apiospermum shows its metabolic potential to degrade hydrocarbons. Stand Genomic Sci. 2017 Dec 4;12:71. doi: 10.1186/s40793-017-0287-6. eCollection 2017. PubMed PMID: 29225727; PubMed Central PMCID: PMC5716253.

20: Shi Y, Kamer PCJ, Cole-Hamilton DJ, Harvie M, Baxter EF, Lim KJC, Pogorzelec P. A new route to N-aromatic heterocycles from the hydrogenation of diesters in the presence of anilines. Chem Sci. 2017 Oct 1;8(10):6911-6917. doi: 10.1039/c7sc01718a. Epub 2017 Aug 8. PubMed PMID: 29147516; PubMed Central PMCID: PMC5636942.