H 261

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597335

CAS#: 91464-97-0

Description: H 261 is an oligopeptide.

Chemical Structure

H 261
CAS# 91464-97-0

Theoretical Analysis

MedKoo Cat#: 597335
Name: H 261
CAS#: 91464-97-0
Chemical Formula: C50H73N13O9
Exact Mass: 999.5654
Molecular Weight: 1000.21
Elemental Analysis: C, 60.04; H, 7.36; N, 18.21; O, 14.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: H 261; H-261; H261; H 261 Oligopeptide; H-261 Oligopeptide;

IUPAC/Chemical Name: ((2S,3R,4S)-2-(N-(L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl)-7-methyloctanamido)-5-amino-4-hydroxy-2-isopropyl-3-methylpentanoyl)-L-histidine


InChi Code: InChI=1S/C50H73N13O9/c1-30(2)13-8-6-11-17-43(65)63(50(31(3)4,32(5)42(64)23-51)49(72)61-40(48(70)71)22-36-26-55-29-58-36)47(69)39(21-35-25-54-28-57-35)60-44(66)38(19-33-14-9-7-10-15-33)59-45(67)41-16-12-18-62(41)46(68)37(52)20-34-24-53-27-56-34/h7,9-10,14-15,24-32,37-42,64H,6,8,11-13,16-23,51-52H2,1-5H3,(H,53,56)(H,54,57)(H,55,58)(H,59,67)(H,60,66)(H,61,72)(H,70,71)/t32-,37-,38-,39-,40-,41-,42+,50-/m0/s1

SMILES Code: O=C(O)[C@H](CC1=CNC=N1)NC([C@@]([C@@H](C)[C@H](O)CN)(C(C)C)N(C([C@H](CC2=CNC=N2)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H](CC5=CNC=N5)N)=O)CCC4)=O)=O)=O)C(CCCCCC(C)C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1000.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yang A, Pon Q, Lavoie A, Crawford JJ, Harenberg S, Zimmermann RH, Booker J, Kelly S, Lavi S, Cantor WJ, Mehta SR, Bagai A, Goodman SG, Cheema AN, Dehghani P. Long-term pharmacodynamic effects of Ticagrelor versus Clopidogrel in fibrinolytic-treated STEMI patients undergoing early PCI. J Thromb Thrombolysis. 2018 Feb;45(2):225-233. doi: 10.1007/s11239-017-1581-2. PubMed PMID: 29170875.

2: Pelletier-Galarneau M, Sogbein OO, Pham X, Hao J, Le J, Strober MD, Middleton ML, Kikut J, Freeman LM, Zuckier LS. Multicenter validation of a shortened gastric-emptying protocol. J Nucl Med. 2015 Jun;56(6):873-6. doi: 10.2967/jnumed.115.155366. Epub 2015 Apr 16. PubMed PMID: 25883124.

3: Fox KA, Carruthers KF, Dunbar DR, Graham C, Manning JR, De Raedt H, Buysschaert I, Lambrechts D, Van de Werf F. Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study). Eur Heart J. 2010 Nov;31(22):2755-64. doi: 10.1093/eurheartj/ehq326. Epub 2010 Aug 30. PubMed PMID: 20805110.

4: Kresch R, Merhav N. Fast DCT domain filtering using the DCT and the DST. IEEE Trans Image Process. 1999;8(6):821-33. doi: 10.1109/83.766859. PubMed PMID: 18267495.

5: Coates L, Erskine PT, Mall S, Gill R, Wood SP, Myles DA, Cooper JB. X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases. Eur Biophys J. 2006 Sep;35(7):559-66. Epub 2006 May 4. PubMed PMID: 16673078.

6: Ohngemach S, Buck C, Simon P, Schaeffel F, Feldkaemper M. Temporal changes of novel transcripts in the chicken retina following imposed defocus. Mol Vis. 2004 Dec 28;10:1019-27. PubMed PMID: 15635295.

7: Angstwurm K, Hanisch UK, Gassemi T, Bille MB, Prinz M, Dirnagl U, Kettenmann H, Weber JR. Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infect Immun. 2004 Jun;72(6):3294-8. PubMed PMID: 15155632; PubMed Central PMCID: PMC415676.

8: Erskine PT, Coates L, Mall S, Gill RS, Wood SP, Myles DA, Cooper JB. Atomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptides. Protein Sci. 2003 Aug;12(8):1741-9. PubMed PMID: 12876323; PubMed Central PMCID: PMC2323960.

9: Coates L, Erskine PT, Wood SP, Myles DA, Cooper JB. A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism. Biochemistry. 2001 Nov 6;40(44):13149-57. PubMed PMID: 11683623.

10: Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, Zollner AN, Morgan DG, Morgan I, Ghatei MA, Small CJ, Bloom SR. Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinology. 2001 Aug;142(8):3457-63. PubMed PMID: 11459791.

11: Cooper JB, Myles DA. A preliminary neutron Laue diffraction study of the aspartic proteinase endothiapepsin. Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):246-8. PubMed PMID: 10666618.

12: Stewart BK, Carter SJ, Cook JN, Abbe BS, Pinck D, Rowberg AH. Application of the advanced communications technology satellite to teleradiology and real-time compressed ultrasound video telemedicine. J Digit Imaging. 1999 May;12(2):68-76. Review. PubMed PMID: 10342249; PubMed Central PMCID: PMC3452490.

13: Han KS, Woo SJ, Koo CH, Lee MG. Pharmacokinetics of a chemoprotective agent, 2-(allylthio)pyrazine, after intravenous administration to rabbits. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):29-34. PubMed PMID: 9644716.

14: Gómez J, Semo N, Freire E. Structural thermodynamic study of the binding of renin inhibitors to endothiapepsin. Adv Exp Med Biol. 1998;436:325-8. PubMed PMID: 9561236.

15: Zeni AI, Hoffman MD, Clifford PS. Energy expenditure with indoor exercise machines. JAMA. 1996 May 8;275(18):1424-7. PubMed PMID: 8618368.

16: Lee X, Zhang YQ, Leon-Garcia A. Information loss recovery for block-based image coding techniques-a fuzzy logic approach. IEEE Trans Image Process. 1995;4(3):259-73. PubMed PMID: 18289977.

17: Banham MR, Brailean JC, Chan CL, Katsaggelos AK. Low bit rate video coding using robust motion vector regeneration in the decoder. IEEE Trans Image Process. 1994;3(5):652-65. PubMed PMID: 18291958.

18: Gold RH, Kangarloo H, Yaghmai I, Grant EG, Stewart BK, Mankovich NJ, Sayre JW, Dwyer SJ 3rd. Teleconferencing for cost-effective sharing of radiology educational resources: potential and technical development. AJR Am J Roentgenol. 1993 Jun;160(6):1309-11. PubMed PMID: 8498240.

19: Hughes CJ, Ghanbari M, Pearson DE, Seferidis V, Xiong J. Modeling and subjective assessment of cell discard in ATM video. IEEE Trans Image Process. 1993;2(2):212-22. PubMed PMID: 18296209.

20: Gustchina A, Weber IT. Comparative analysis of the sequences and structures of HIV-1 and HIV-2 proteases. Proteins. 1991;10(4):325-39. PubMed PMID: 1946342.