P-113

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597322

CAS#: 190673-58-6

Description: P-113 is an antimicrobial peptide.


Price and Availability

Size
Price

Size
Price

Size
Price

P-113 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 597322
Name: P-113
CAS#: 190673-58-6
Chemical Formula: C71H110N28O13
Exact Mass: 1562.8807
Molecular Weight: 1563.84
Elemental Analysis: C, 54.53; H, 7.09; N, 25.08; O, 13.30


Synonym: P-113; P 113; P113; Ala-lys-arg-his-his-gly-tyr-lys-arg-lys-phe-his-NH2;

IUPAC/Chemical Name: (S)-N-((6S,9S,12S,15S)-15-((1H-imidazol-4-yl)methyl)-1,16-diamino-9-(4-aminobutyl)-12-benzyl-1-imino-7,10,13,16-tetraoxo-2,8,11,14-tetraazahexadecan-6-yl)-6-amino-2-((2S,8S,11S,14S,17S,20S)-8,11-bis((1H-imidazol-4-yl)methyl)-20-amino-17-(4-aminobutyl)-14-(3-guanidinopropyl)-2-(4-hydroxybenzyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazahenicosanamido)hexanamide

InChi Key: UIBPZXXSPHGPDS-GUBPWTFESA-N

InChi Code: InChI=1S/C71H110N28O13/c1-41(75)60(103)91-48(15-5-8-24-72)62(105)94-52(19-12-28-85-71(79)80)66(109)99-57(33-46-36-83-40-89-46)69(112)98-56(32-45-35-82-39-88-45)61(104)86-37-58(101)90-54(30-43-20-22-47(100)23-21-43)67(110)95-49(16-6-9-25-73)63(106)93-51(18-11-27-84-70(77)78)64(107)92-50(17-7-10-26-74)65(108)97-55(29-42-13-3-2-4-14-42)68(111)96-53(59(76)102)31-44-34-81-38-87-44/h2-4,13-14,20-23,34-36,38-41,48-57,100H,5-12,15-19,24-33,37,72-75H2,1H3,(H2,76,102)(H,81,87)(H,82,88)(H,83,89)(H,86,104)(H,90,101)(H,91,103)(H,92,107)(H,93,106)(H,94,105)(H,95,110)(H,96,111)(H,97,108)(H,98,112)(H,99,109)(H4,77,78,84)(H4,79,80,85)/t41-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CNC=N1)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CC3=CC=C(O)C=C3)NC(CNC([C@H](CC4=CNC=N4)NC([C@H](CC5=CNC=N5)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Lee KW, Moon KH, Ma CH, Lee GS, Yang DS, Choy WS. Clinical and Radiologic Outcomes After Medializing and Not Medializing Rotator Cuff Tendon Attachment Site on Chronic Retracted Rotator Cuff Tears. Arthroscopy. 2018 May 24. pii: S0749-8063(18)30235-4. doi: 10.1016/j.arthro.2018.03.015. [Epub ahead of print] PubMed PMID: 29804954.

2: Portela-Camino JA, Martín-González S, Ruiz-Alcocer J, Illarramendi-Mendicute I, Garrido-Mercado R. A Random Dot Computer Video Game Improves Stereopsis. Optom Vis Sci. 2018 Jun;95(6):523-535. doi: 10.1097/OPX.0000000000001222. PubMed PMID: 29787486.

3: Wang H, Ai L, Zhang Y, Cheng J, Yu H, Li C, Zhang D, Pan Y, Lin L. The Effects of Antimicrobial Peptide Nal-P-113 on Inhibiting Periodontal Pathogens and Improving Periodontal Status. Biomed Res Int. 2018 Mar 15;2018:1805793. doi: 10.1155/2018/1805793. eCollection 2018. PubMed PMID: 29736391; PubMed Central PMCID: PMC5875022.

4: Shi B, Zhao Q, Xu L, Liu Z, Sun X, Zhu Z, Qiu Y. SRS-Schwab Grade 4 osteotomy for congenital thoracolumbar kyphosis: a minimum of 2 years follow-up study. Spine J. 2018 Apr 20. pii: S1529-9430(18)30165-7. doi: 10.1016/j.spinee.2018.04.011. [Epub ahead of print] PubMed PMID: 29680510.

5: Cheng KT, Wu CL, Yip BS, Yu HY, Cheng HT, Chih YH, Cheng JW. High Level Expression and Purification of the Clinically Active Antimicrobial Peptide P-113 in Escherichia coli. Molecules. 2018 Mar 30;23(4). pii: E800. doi: 10.3390/molecules23040800. PubMed PMID: 29601518.

6: Basar O, Yuksel O, Yang DJ, Samarasena J, Forcione D, DiMaio CJ, Wagh MS, Chang K, Casey B, Fernandez-Del Castillo C, Pitman MB, Brugge WR. Feasibility and safety of microforceps biopsy in the diagnosis of pancreatic cysts. Gastrointest Endosc. 2018 Jul;88(1):79-86. doi: 10.1016/j.gie.2018.02.039. Epub 2018 Mar 3. PubMed PMID: 29510146.

7: Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips JJ, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M. Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Front Genet. 2017 Dec 22;8:221. doi: 10.3389/fgene.2017.00221. eCollection 2017. PubMed PMID: 29285026; PubMed Central PMCID: PMC5744015.

8: Bale R, Richter M, Dünser M, Levy E, Buchberger W, Schullian P. Stereotactic Radiofrequency Ablation for Breast Cancer Liver Metastases. J Vasc Interv Radiol. 2018 Feb;29(2):262-267. doi: 10.1016/j.jvir.2017.09.027. Epub 2017 Dec 19. PubMed PMID: 29273283.

9: Habib SR, Al Ajmi MG, Al Dhafyan M, Jomah A, Abualsaud H, Almashali M. Effect of Margin Designs on the Marginal Adaptation of Zirconia Copings. Acta Stomatol Croat. 2017 Sep;51(3):179-187. doi: 10.15644/asc51/3/1. PubMed PMID: 29225358; PubMed Central PMCID: PMC5708331.

10: Blackburn C, Rask H, Awada A. Mechanical properties of resin-ceramic CAD-CAM materials after accelerated aging. J Prosthet Dent. 2017 Nov 29. pii: S0022-3913(17)30574-7. doi: 10.1016/j.prosdent.2017.08.016. [Epub ahead of print] PubMed PMID: 29195816.

11: Ten Brink AF, Visser-Meily JMA, Schut MJ, Kouwenhoven M, Eijsackers ALH, Nijboer TCW. Prism Adaptation in Rehabilitation? No Additional Effects of Prism Adaptation on Neglect Recovery in the Subacute Phase Poststroke: A Randomized Controlled Trial. Neurorehabil Neural Repair. 2017 Dec;31(12):1017-1028. doi: 10.1177/1545968317744277. Epub 2017 Dec 1. PubMed PMID: 29192535.

12: Fathi M, Valiee S, Mahmoodi P. Effect of changing the duration of keeping sandbag over catheter insertion site on the coronary angiography acute complications: A controlled clinical trial. J Vasc Nurs. 2017 Dec;35(4):193-200. doi: 10.1016/j.jvn.2017.05.001. Epub 2017 Jun 23. PubMed PMID: 29153227.

13: Gimovsky AC, Whitney B, Wood D, Weiner S. Association between fetal myocardial performance index and fetal heart rate monitoring: a prospective observational cohort study. J Matern Fetal Neonatal Med. 2017 Nov 13:1-6. doi: 10.1080/14767058.2017.1399119. [Epub ahead of print] PubMed PMID: 29132252.

14: Wang HY, Lin L, Fu W, Yu HY, Yu N, Tan LS, Cheng JW, Pan YP. Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1β and TNF-α production. BMC Complement Altern Med. 2017 Aug 29;17(1):426. doi: 10.1186/s12906-017-1931-9. PubMed PMID: 28851350; PubMed Central PMCID: PMC5576277.

15: Skripnikov LV. Combined 4-component and relativistic pseudopotential study of ThO for the electron electric dipole moment search. J Chem Phys. 2016 Dec 7;145(21):214301. doi: 10.1063/1.4968229. PubMed PMID: 28799403.

16: Outinen TK, Mantula P, Laine OK, Pörsti I, Vaheri A, Mäkelä SM, Mustonen J. Haematuria is a marker for the severity of acute kidney injury but does not associate with thrombocytopenia in acute Puumala hantavirus infection. Infect Dis (Lond). 2017 Nov - Dec;49(11-12):840-846. doi: 10.1080/23744235.2017.1358461. Epub 2017 Aug 1. PubMed PMID: 28762841.

17: McDermott MM, Polonsky TS, Kibbe MR, Tian L, Zhao L, Pearce WH, Gao Y, Guralnik JM. Racial differences in functional decline in peripheral artery disease and associations with socioeconomic status and education. J Vasc Surg. 2017 Sep;66(3):826-834. doi: 10.1016/j.jvs.2017.02.037. Epub 2017 May 11. PubMed PMID: 28502539; PubMed Central PMCID: PMC5621652.

18: Chaumet-Riffaud AE, Chaumet-Riffaud P, Cariou A, Devisme C, Audo I, Sahel JA, Mohand-Said S. Impact of Retinitis Pigmentosa on Quality of Life, Mental Health, and Employment Among Young Adults. Am J Ophthalmol. 2017 May;177:169-174. doi: 10.1016/j.ajo.2017.02.016. Epub 2017 Feb 22. PubMed PMID: 28237413.

19: Koramaz İ, El Kılıç H, Gökalp F, Bitargil M, Bektaş N, Engin E, Egici MT, Bozkurt AK. Ablation of the great saphenous vein with nontumescent n-butyl cyanoacrylate versus endovenous laser therapy. J Vasc Surg Venous Lymphat Disord. 2017 Mar;5(2):210-215. doi: 10.1016/j.jvsv.2016.09.007. Epub 2017 Jan 12. PubMed PMID: 28214489.

20: Wang HY, Lin L, Tan LS, Yu HY, Cheng JW, Pan YP. Molecular pathways underlying inhibitory effect of antimicrobial peptide Nal-P-113 on bacteria biofilms formation of Porphyromonas gingivalis W83 by DNA microarray. BMC Microbiol. 2017 Feb 17;17(1):37. doi: 10.1186/s12866-017-0948-z. PubMed PMID: 28212615; PubMed Central PMCID: PMC5316201.