CAY10566
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555272

CAS#: 944808-88-2

Description: CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.


Price and Availability

Size
Price

100mg
USD 1150
1g
USD 3450
Size
Price

200mg
USD 1850
2g
USD 5450
Size
Price

500mg
USD 2650
5g
USD 7650

CAY10566, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555272
Name: CAY10566
CAS#: 944808-88-2
Chemical Formula: C18H17ClFN5O2
Exact Mass: 389.1055
Molecular Weight: 389.82
Elemental Analysis: C, 55.46; H, 4.40; Cl, 9.09; F, 4.87; N, 17.97; O, 8.21


Synonym: CAY10566; CAY-10566; CAY 10566;

IUPAC/Chemical Name: 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine

InChi Key: WFOFPVXMPTVOTJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17ClFN5O2/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19/h2-5,10,13H,6-9H2,1H3

SMILES Code: CC1=NN=C(C2=NN=C(N3CCC(OC4=CC(F)=CC=C4Cl)CC3)C=C2)O1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Fayezi S, Ghaffari Novin M, Darabi M, Norouzian M, Nouri M, Farzadi L, Darabi M. Primary Culture of Human Cumulus Cells Requires Stearoyl-Coenzyme A Desaturase 1 Activity for Steroidogenesis and Enhancing Oocyte In Vitro Maturation. Reprod Sci. 2018 Jun;25(6):844-853. doi: 10.1177/1933719117698578. Epub 2017 Mar 27. PubMed PMID: 28345489.

2: Yu XQ, Cai C, Du X, Shen W. [Effect of hypoxia-inducible factor-2α/stearoyl-CoA desaturase-1 pathway on biological behaviors of hepatoma cells induced by hypoxia]. Zhonghua Gan Zang Bing Za Zhi. 2016 Jul 20;24(7):506-512. doi: 10.3760/cma.j.issn.1007-3418.2016.07.005. Chinese. PubMed PMID: 27784428.

3: Wang Y, da Cruz TC, Pulfemuller A, Grégoire S, Ferveur JF, Moussian B. INHIBITION OF FATTY ACID DESATURASES IN Drosophila melanogaster LARVAE BLOCKS FEEDING AND DEVELOPMENTAL PROGRESSION. Arch Insect Biochem Physiol. 2016 May;92(1):6-23. doi: 10.1002/arch.21329. Epub 2016 Apr 1. PubMed PMID: 27037621.

4: Ralston JC, Mutch DM. SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition. Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:29-37. doi: 10.1016/j.plefa.2015.04.008. Epub 2015 Apr 28. PubMed PMID: 25959085.

5: Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O. Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis. FASEB J. 2015 Jun;29(6):2439-49. doi: 10.1096/fj.14-268474. Epub 2015 Feb 12. PubMed PMID: 25678624.

6: Mohammadzadeh F, Mosayebi G, Montazeri V, Darabi M, Fayezi S, Shaaker M, Rahmati M, Baradaran B, Mehdizadeh A, Darabi M. Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition. J Breast Cancer. 2014 Jun;17(2):136-42. doi: 10.4048/jbc.2014.17.2.136. Epub 2014 Jun 27. PubMed PMID: 25013434; PubMed Central PMCID: PMC4090315.

7: Koeberle A, Shindou H, Harayama T, Shimizu T. Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol. J Biol Chem. 2012 Aug 3;287(32):27244-54. doi: 10.1074/jbc.M111.274829. Epub 2012 Jun 14. PubMed PMID: 22700983; PubMed Central PMCID: PMC3411066.

8: Masuda M, Ting TC, Levi M, Saunders SJ, Miyazaki-Anzai S, Miyazaki M. Activating transcription factor 4 regulates stearate-induced vascular calcification. J Lipid Res. 2012 Aug;53(8):1543-52. doi: 10.1194/jlr.M025981. Epub 2012 May 23. PubMed PMID: 22628618; PubMed Central PMCID: PMC3540843.