LM22B-10
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555271

CAS#: 342777-54-2

Description: LM22B-10 is a TrkB and TrkC agonist. LM22B-10 exhibits neurotrophic activity (EC50 = 200-300 nM). LM22B-10 improves survival and increases neurite outgrowth in hippocampal cells in vitro. LM22B-10 increased cell survival and strongly accelerated neurite outgrowth, superseding the effects of brain-derived neurotrophic factor (BDNF), NT-3 or the two combined.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 2250
5g
USD 7850
Size
Price

100mg
USD 850
1g
USD 3450
Size
Price

200mg
USD 1450
2g
USD 5650

LM22B-10, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555271
Name: LM22B-10
CAS#: 342777-54-2
Chemical Formula: C27H33ClN2O4
Exact Mass: 484.2129
Molecular Weight: 485.021
Elemental Analysis: C, 66.86; H, 6.86; Cl, 7.31; N, 5.78; O, 13.19


Synonym: LM22B-10; LM22B 10; LM22B10; LM 22B10; LM-22B10; LM22B10;

IUPAC/Chemical Name: 2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

InChi Key: QCXQLSGBOUUVNH-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H33ClN2O4/c28-24-7-1-21(2-8-24)27(22-3-9-25(10-4-22)29(13-17-31)14-18-32)23-5-11-26(12-6-23)30(15-19-33)16-20-34/h1-12,27,31-34H,13-20H2

SMILES Code: ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Zhang T, Liao JY, Yu L, Liu GS. Regulating effect of glycyrrhetinic acid on
bronchial asthma smooth muscle proliferation and apoptosis as well as
inflammatory factor expression through ERK1/2 signaling pathway. Asian Pac J Trop
Med. 2017 Dec;10(12):1172-1176. doi: 10.1016/j.apjtm.2017.10.025. Epub 2017 Oct
28. PubMed PMID: 29268974.

2: Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro
S, Longo FM. A small molecule TrkB/TrkC neurotrophin receptor co-activator with
distinctive effects on neuronal survival and process outgrowth.
Neuropharmacology. 2016 Nov;110(Pt A):343-361. doi:
10.1016/j.neuropharm.2016.06.015. Epub 2016 Jun 19. PubMed PMID: 27334657.