Factor 390 A

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MedKoo CAT#: 597252

CAS#: 95617-07-5

Description: Factor 390 A is the phosphodiester between AMP & methanogen factor 420.

Chemical Structure

Factor 390 A
CAS# 95617-07-5

Theoretical Analysis

MedKoo Cat#: 597252
Name: Factor 390 A
CAS#: 95617-07-5
Chemical Formula: C39H48N10O24P2
Exact Mass: 1102.2318
Molecular Weight: 1102.8
Elemental Analysis: C, 42.48; H, 4.39; N, 12.70; O, 34.82; P, 5.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Factor 390 A; F390-A; F390 A; F390A; P-5-(S)-N-(N-(1-Oxo-2-(phosphonooxy)propyl)-L-gamma-glutamyl)-L-glutamate;

IUPAC/Chemical Name: ((R)-4-((R)-2-(((S)-(((2S,3R,4R)-5-(7-(((R)-(((2R,3R,4S,5S)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-2,3,4-trihydroxypentyl)oxy)(hydroxy)phosphoryl)oxy)propanamido)-4-carboxybutanoyl)-L-glutamic acid


InChi Code: 1S/C39H48N10O24P2/c1-15(34(58)45-20(38(62)63)3-6-25(52)44-19(37(60)61)4-7-26(53)54)72-74(65,66)69-11-23(51)28(55)22(50)10-48-21-5-2-17(8-16(21)9-18-32(48)46-39(64)47-35(18)59)73-75(67,68)70-12-24-29(56)30(57)36(71-24)49-14-43-27-31(40)41-13-42-33(27)49/h2,5,8-9,13-15,19-20,22-24,28-30,36,50-51,55-57H,3-4,6-7,10-12H2,1H3,(H,44,52)(H,45,58)(H,53,54)(H,60,61)(H,62,63)(H,65,66)(H,67,68)(H2,40,41,42)(H,47,59,64)

SMILES Code: O=C(N[C@H](CCC(N[C@H](C(O)=O)CCC(O)=O)=O)C(O)=O)[C@@H](C)O[P@@](O)(OC[C@H](O)[C@H](O)[C@H](O)Cn(c(ccc(O[P@@](OC[C@@H]1[C@H](O)[C@H](O)[C@H](O1)n2cnc3c2ncnc3N)(O)=O)c4)c4cc5c6=O)c5nc([nH]6)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1102.8 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pennings JL, Keltjens JT, Vogels GD. Isolation and characterization of Methanobacterium thermoautotrophicum DeltaH mutants unable to grow under hydrogen-deprived conditions. J Bacteriol. 1998 May;180(10):2676-81. PubMed PMID: 9573152; PubMed Central PMCID: PMC107219.

2: Vermeij P, Pennings JL, Maassen SM, Keltjens JT, Vogels GD. Cellular levels of factor 390 and methanogenic enzymes during growth of Methanobacterium thermoautotrophicum deltaH. J Bacteriol. 1997 Nov;179(21):6640-8. PubMed PMID: 9352911; PubMed Central PMCID: PMC179590.

3: van de Wijngaard WM, vermey P, van der Drift C. Formation of factor 390 by cell extracts of Methanosarcina barkeri. J Bacteriol. 1991 Apr;173(8):2710-1. PubMed PMID: 2013583; PubMed Central PMCID: PMC207842.

4: Kengen SW, von den Hoff HW, Keltjens JT, van der Drift C, Vogels GD. Hydrolysis and reduction of factor 390 by cell extracts of Methanobacterium thermoautotrophicum (strain delta H). J Bacteriol. 1991 Apr;173(7):2283-8. PubMed PMID: 2007552; PubMed Central PMCID: PMC207780.

5: Gloss LM, Hausinger RP. Methanogen factor 390 formation: species distribution, reversibility and effects of non-oxidative cellular stresses. Biofactors. 1988 Oct;1(3):237-40. PubMed PMID: 2855706.

6: Hausinger RP, Orme-Johnson WH, Walsh C. Factor 390 chromophores: phosphodiester between AMP or GMP and methanogen factor 420. Biochemistry. 1985 Mar 26;24(7):1629-33. PubMed PMID: 2988607.