WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597245
CAS#: 41432-72-8
Description: 10-Formylfolate tetraglutamate, also known as 10-Formylpteroylpentaglutamate or 10-CHOFA(glu)4, is a folate conjugate. 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.
MedKoo Cat#: 597245
Name: 10-Formylfolate tetraglutamate
CAS#: 41432-72-8
Chemical Formula: C40H47N11O19
Exact Mass: 985.305
Molecular Weight: 985.87
Elemental Analysis: C, 48.73; H, 4.81; N, 15.63; O, 30.83
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Synonym: 10-Formylpteroylpentaglutamate; 10-Formylfolate tetraglutamate; 10-CHOFA(glu)4;
IUPAC/Chemical Name: (3S,8S,13S,18S,23S)-1-(4-(N-((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)formamido)phenyl)-1,6,11,16,21-pentaoxo-2,7,12,17,22-pentaazapentacosane-3,8,13,18,23,25-hexacarboxylic acid
InChi Key: AIQOHUVZTIREKD-KEOOTSPTSA-N
InChi Code: InChI=1S/C40H47N11O19/c41-40-49-32-31(34(60)50-40)43-19(15-42-32)16-51(17-52)20-3-1-18(2-4-20)33(59)48-25(39(69)70)8-13-29(56)46-23(37(65)66)6-11-27(54)44-21(35(61)62)5-10-26(53)45-22(36(63)64)7-12-28(55)47-24(38(67)68)9-14-30(57)58/h1-4,15,17,21-25H,5-14,16H2,(H,44,54)(H,45,53)(H,46,56)(H,47,55)(H,48,59)(H,57,58)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H,69,70)(H3,41,42,49,50,60)/t21-,22-,23-,24-,25-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=CN=C3NC(N)=NC(C3=N2)=O)C=O)C=C1)=O)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 985.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Pheasant AE, Bates J, Blair JA, Nayyir-Mazhir R. Investigations of tissue folates in normal and malignant tissues. Br J Cancer. 1983 Mar;47(3):393-8. doi: 10.1038/bjc.1983.59. PMID: 6830689; PMCID: PMC2011316.
2: Connor MJ, Blair JA. The identification of the folate conjugates found in rat liver 48 h after the administration of radioactively labelled folate tracers. Biochem J. 1980 Jan 15;186(1):235-42. doi: 10.1042/bj1860235. PMID: 6892769; PMCID: PMC1161524.
3: Connor MJ, Pheasant AE, Blair JA. The identification of p-acetamidobenzoate as a folate degradation product in rat urine. Biochem J. 1979 Mar 15;178(3):795-797. doi: 10.1042/bj1780795. PMID: 454383; PMCID: PMC1186581.
