WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597227
CAS#: 119770-54-6
Description: 11-Deazahomofolic acid is an inhibitor of phosphoribosylglycinamide formyltransferase.
MedKoo Cat#: 597227
Name: 11-Deazahomofolic acid
CAS#: 119770-54-6
Chemical Formula: C21H22N6O6
Exact Mass: 454.1601
Molecular Weight: 454.44
Elemental Analysis: C, 55.50; H, 4.88; N, 18.49; O, 21.12
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Synonym: 11-Deazahomofolic acid;
IUPAC/Chemical Name: (4-(3-(2-amino-4-oxo-1,4-dihydropteridin-6-yl)propyl)benzoyl)-L-glutamic acid
InChi Key: MJHZEXKOLNBMAE-AWEZNQCLSA-N
InChi Code: InChI=1S/C21H22N6O6/c22-21-26-17-16(19(31)27-21)24-13(10-23-17)3-1-2-11-4-6-12(7-5-11)18(30)25-14(20(32)33)8-9-15(28)29/h4-7,10,14H,1-3,8-9H2,(H,25,30)(H,28,29)(H,32,33)(H3,22,23,26,27,31)/t14-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCCC2=CN=C3NC(N)=NC(C3=N2)=O)C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 454.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nair MG, Murthy BR, Patil SD, Kisliuk RL, Thorndike J, Gaumont Y, Ferone R, Duch DS, Edelstein MP. Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase. J Med Chem. 1989 Jun;32(6):1277-83. PubMed PMID: 2498518.
