10-Cl-BBQ
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563132

CAS#: 23982-76-5

Description: 10-Cl-BBQ is an aryl hydrocarbon receptor (AhR) ligand.

Chemical Structure

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10-Cl-BBQ
CAS# 23982-76-5
Instruction

Theoretical Analysis

MedKoo Cat#: 563132
Name: 10-Cl-BBQ
CAS#: 23982-76-5
Chemical Formula: C18H9ClN2O
Exact Mass: 304.04
Molecular Weight: 304.730
Elemental Analysis: C, 70.95; H, 2.98; Cl, 11.63; N, 9.19; O, 5.25

Price and Availability

Size Price Availability Quantity
5mg USD 265 2 Weeks
25mg USD 800 2 Weeks
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Synonym: 10-Cl-BBQ; 10 Cl BBQ; 10ClBBQ;

IUPAC/Chemical Name: 10-Chloro-7H-benzimidazo[2,1-a]benzo[de]Iso-quinolin-7-one

InChi Key: ZJESJVGSDQOZAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H9ClN2O/c19-11-7-8-14-15(9-11)21-17(20-14)12-5-1-3-10-4-2-6-13(16(10)12)18(21)22/h1-9H

SMILES Code: O=C(C1=CC=CC2=CC=CC3=C12)N4C3=NC5=CC=C(Cl)C=C54

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 304.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ehrlich AK, Pennington JM, Wang X, Rohlman D, Punj S, Löhr CV, Newman MT, Kolluri SK, Kerkvliet NI. Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice. J Immunol. 2016 Jan 1;196(1):264-73. doi: 10.4049/jimmunol.1501789. Epub 2015 Nov 16. PubMed PMID: 26573835; PubMed Central PMCID: PMC4684970.

2: Punj S, Kopparapu P, Jang HS, Phillips JL, Pennington J, Rohlman D, O'Donnell E, Iversen PL, Kolluri SK, Kerkvliet NI. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One. 2014 Feb 19;9(2):e88726. doi: 10.1371/journal.pone.0088726. eCollection 2014. PubMed PMID: 24586378; PubMed Central PMCID: PMC3929365.