WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597218
CAS#: 78520-72-6
Description: 11-Oxahomoaminopterin shows antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.
MedKoo Cat#: 597218
Name: 11-Oxahomoaminopterin
CAS#: 78520-72-6
Chemical Formula: C20H21N7O6
Exact Mass: 455.1553
Molecular Weight: 455.43
Elemental Analysis: C, 52.75; H, 4.65; N, 21.53; O, 21.08
This product is not in stock, which may be available by custom synthesis.
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Synonym: 11-Oxahomoaminopterin; NSC 325304; NSC-325304; NSC325304;
IUPAC/Chemical Name: (4-(2-(2,4-diaminopteridin-6-yl)ethoxy)benzoyl)-L-glutamic acid
InChi Key: JTHMPDYXHCUKIJ-ZDUSSCGKSA-N
InChi Code: InChI=1S/C20H21N7O6/c21-16-15-17(27-20(22)26-16)23-9-11(24-15)7-8-33-12-3-1-10(2-4-12)18(30)25-13(19(31)32)5-6-14(28)29/h1-4,9,13H,5-8H2,(H,25,30)(H,28,29)(H,31,32)(H4,21,22,23,26,27)/t13-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(OCCC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 455.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nair MG, Bridges TW, Henkel TJ, Kisliuk RL, Gaumont Y, Sirotnak FM. Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds. J Med Chem. 1981 Sep;24(9):1068-73. PubMed PMID: 6793726.
