WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597217
CAS#: 72254-43-4
Description: 11-Oxahomofolic acid is a potential antitumor agent.
MedKoo Cat#: 597217
Name: 11-Oxahomofolic acid
CAS#: 72254-43-4
Chemical Formula: C20H20N6O7
Exact Mass: 456.1393
Molecular Weight: 456.41
Elemental Analysis: C, 52.63; H, 4.42; N, 18.41; O, 24.54
This product is not in stock, which may be available by custom synthesis.
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Synonym: 11-Oxahomofolic acid;
IUPAC/Chemical Name: (4-(2-(2-amino-4-oxo-1,4-dihydropteridin-6-yl)ethoxy)benzoyl)-L-glutamic acid
InChi Key: KIWDKYBQSARKOL-ZDUSSCGKSA-N
InChi Code: InChI=1S/C20H20N6O7/c21-20-25-16-15(18(30)26-20)23-11(9-22-16)7-8-33-12-3-1-10(2-4-12)17(29)24-13(19(31)32)5-6-14(27)28/h1-4,9,13H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H3,21,22,25,26,30)/t13-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(OCCC2=CN=C3NC(N)=NC(C3=N2)=O)C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 456.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nair MG, Saunders C, Chen SY, Kisliuk RL, Gaumont Y. Folate analogues altered in the C9--N10 bridge region. 14. 11-Oxahomofolic acid, a potential antitumor agent. J Med Chem. 1980 Jan;23(1):59-65. PubMed PMID: 6767031.
