Zearalenone | CAS#17924-92-4 | mycotoxin

Zearalenone
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563124

CAS#: 17924-92-4

Description: Zearalenone is a mycotoxin produced by Fusarium. It acts by binding the estrogen receptor (ER).

Chemical Structure

Zearalenone

CAS# 17924-92-4

Instruction

Theoretical Analysis

MedKoo Cat#: 563124
Name: Zearalenone
CAS#: 17924-92-4
Chemical Formula: C18H22O5
Exact Mass: 318.15
Molecular Weight: 318.360
Elemental Analysis: C, 67.91; H, 6.97; O, 25.13

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 210
10mg	USD 350
25mg	USD 590
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Zearalenone; ZEA; RAL; F-2 toxin; F 2 toxin; F2 toxin;

IUPAC/Chemical Name: (3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione

InChi Key: MBMQEIFVQACCCH-QBODLPLBSA-N

InChi Code: InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1

SMILES Code: O=C(O[C@@H](C)CCC1)C2=C(O)C=C(O)C=C2/C=C/CCCC1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 318.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bertero A, Moretti A, Spicer LJ, Caloni F. Fusarium Molds and Mycotoxins: Potential Species-Specific Effects. Toxins (Basel). 2018 Jun 15;10(6). pii: E244. doi: 10.3390/toxins10060244. Review. PubMed PMID: 29914090.

2: Nleya N, Adetunji MC, Mwanza M. Current Status of Mycotoxin Contamination of Food Commodities in Zimbabwe. Toxins (Basel). 2018 May 3;10(5). pii: E89. doi: 10.3390/toxins10050089. Review. PubMed PMID: 29751574; PubMed Central PMCID: PMC5983227.

3: Zheng W, Wang B, Li X, Wang T, Zou H, Gu J, Yuan Y, Liu X, Bai J, Bian J, Liu Z. Zearalenone Promotes Cell Proliferation or Causes Cell Death? Toxins (Basel). 2018 May 2;10(5). pii: E184. doi: 10.3390/toxins10050184. Review. PubMed PMID: 29724047; PubMed Central PMCID: PMC5983240.

4: Ogunade IM, Martinez-Tuppia C, Queiroz OCM, Jiang Y, Drouin P, Wu F, Vyas D, Adesogan AT. Silage review: Mycotoxins in silage: Occurrence, effects, prevention, and mitigation. J Dairy Sci. 2018 May;101(5):4034-4059. doi: 10.3168/jds.2017-13788. Review. PubMed PMID: 29685276.

5: Bryła M, Waśkiewicz A, Ksieniewicz-Woźniak E, Szymczyk K, Jędrzejczak R. Modified Fusarium Mycotoxins in Cereals and Their Products-Metabolism, Occurrence, and Toxicity: An Updated Review. Molecules. 2018 Apr 20;23(4). pii: E963. doi: 10.3390/molecules23040963. Review. PubMed PMID: 29677133.

6: Liew WP, Mohd-Redzwan S. Mycotoxin: Its Impact on Gut Health and Microbiota. Front Cell Infect Microbiol. 2018 Feb 26;8:60. doi: 10.3389/fcimb.2018.00060. eCollection 2018. Review. PubMed PMID: 29535978; PubMed Central PMCID: PMC5834427.

7: Vila-Donat P, Marín S, Sanchis V, Ramos AJ. A review of the mycotoxin adsorbing agents, with an emphasis on their multi-binding capacity, for animal feed decontamination. Food Chem Toxicol. 2018 Apr;114:246-259. doi: 10.1016/j.fct.2018.02.044. Epub 2018 Feb 21. Review. PubMed PMID: 29476792.

8: Levasseur-Garcia C. Updated Overview of Infrared Spectroscopy Methods for Detecting Mycotoxins on Cereals (Corn, Wheat, and Barley). Toxins (Basel). 2018 Jan 10;10(1). pii: E38. doi: 10.3390/toxins10010038. Review. PubMed PMID: 29320435; PubMed Central PMCID: PMC5793125.

9: Pang J, Cao QF, Sun ZY. [Impact of zearalenone on male fertility: An update]. Zhonghua Nan Ke Xue. 2016 Nov;22(11):1034-1037. Review. Chinese. PubMed PMID: 29281215.

10: Ladeira C, Frazzoli C, Orisakwe OE. Engaging One Health for Non-Communicable Diseases in Africa: Perspective for Mycotoxins. Front Public Health. 2017 Oct 16;5:266. doi: 10.3389/fpubh.2017.00266. eCollection 2017. Review. PubMed PMID: 29085817; PubMed Central PMCID: PMC5650707.

11: Escrivá L, Font G, Manyes L, Berrada H. Studies on the Presence of Mycotoxins in Biological Samples: An Overview. Toxins (Basel). 2017 Aug 18;9(8). pii: E251. doi: 10.3390/toxins9080251. Review. PubMed PMID: 28820481; PubMed Central PMCID: PMC5577585.

12: Robert H, Payros D, Pinton P, Théodorou V, Mercier-Bonin M, Oswald IP. Impact of mycotoxins on the intestine: are mucus and microbiota new targets? J Toxicol Environ Health B Crit Rev. 2017;20(5):249-275. doi: 10.1080/10937404.2017.1326071. Epub 2017 Jun 21. Review. PubMed PMID: 28636450.

13: Alshannaq A, Yu JH. Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food. Int J Environ Res Public Health. 2017 Jun 13;14(6). pii: E632. doi: 10.3390/ijerph14060632. Review. PubMed PMID: 28608841; PubMed Central PMCID: PMC5486318.

14: Degen GH. [Mycotoxins in food : Occurrence, importance and health risk]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 Jul;60(7):745-756. doi: 10.1007/s00103-017-2560-7. Review. German. PubMed PMID: 28508953.

15: Oldenburg E, Höppner F, Ellner F, Weinert J. Fusarium diseases of maize associated with mycotoxin contamination of agricultural products intended to be used for food and feed. Mycotoxin Res. 2017 Aug;33(3):167-182. doi: 10.1007/s12550-017-0277-y. Epub 2017 Apr 28. Review. PubMed PMID: 28455556.

16: Gratz SW. Do Plant-Bound Masked Mycotoxins Contribute to Toxicity? Toxins (Basel). 2017 Feb 28;9(3). pii: E85. doi: 10.3390/toxins9030085. Review. PubMed PMID: 28264486; PubMed Central PMCID: PMC5371840.

17: Du K, Wang C, Liu P, Li Y, Ma X. Effects of Dietary Mycotoxins on Gut Microbiome. Protein Pept Lett. 2017 May 10;24(5):397-405. doi: 10.2174/0929866524666170223095207. Review. PubMed PMID: 28240164.

18: Chilaka CA, De Boevre M, Atanda OO, De Saeger S. The Status of Fusarium Mycotoxins in Sub-Saharan Africa: A Review of Emerging Trends and Post-Harvest Mitigation Strategies towards Food Control. Toxins (Basel). 2017 Jan 5;9(1). pii: E19. doi: 10.3390/toxins9010019. Review. PubMed PMID: 28067768; PubMed Central PMCID: PMC5308251.

19: Gajęcka M, Zielonka Ł, Gajęcki M. Activity of Zearalenone in the Porcine Intestinal Tract. Molecules. 2016 Dec 24;22(1). pii: E18. doi: 10.3390/molecules22010018. Review. PubMed PMID: 28029134.

20: Lee HJ, Ryu D. Worldwide Occurrence of Mycotoxins in Cereals and Cereal-Derived Food Products: Public Health Perspectives of Their Co-occurrence. J Agric Food Chem. 2017 Aug 23;65(33):7034-7051. doi: 10.1021/acs.jafc.6b04847. Epub 2017 Jan 9. Review. PubMed PMID: 27976878.

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