WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591767

CAS#: 91-16-7

Description: Veratrole is a building block for the organic synthesis of other aromatic compounds. Veratrole is relatively electron-rich and thus readily undergoes electrophilic substitution.

Chemical Structure

CAS# 91-16-7

Theoretical Analysis

MedKoo Cat#: 591767
Name: Veratrole
CAS#: 91-16-7
Chemical Formula: C8H10O2
Exact Mass: 138.0681
Molecular Weight: 138.17
Elemental Analysis: C, 69.55; H, 7.30; O, 23.16

Price and Availability

Size Price Availability Quantity
100.0g USD 210.0 2 Weeks
500.0g USD 400.0 2 Weeks
1.0kg USD 470.0 2 Weeks
Bulk inquiry

Synonym: Veratrole; AI3-02281; AI3 02281; AI302281

IUPAC/Chemical Name: 1,2-Dimethoxybenzene


InChi Code: InChI=1S/C8H10O2/c1-9-7-5-3-4-6-8(7)10-2/h3-6H,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 138.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Schröder HV, Witte F, Gaedke M, Sobottka S, Suntrup L, Hupatz H, Valkonen A, Paulus B, Rissanen K, Sarkar B, Schalley CA. An aryl-fused redox-active tetrathiafulvalene with enhanced mixed-valence and radical-cation dimer stabilities. Org Biomol Chem. 2018 Apr 18;16(15):2741-2747. doi: 10.1039/c8ob00415c. PubMed PMID: 29594290.

2: Tay NES, Nicewicz DA. Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis. J Am Chem Soc. 2017 Nov 15;139(45):16100-16104. doi: 10.1021/jacs.7b10076. Epub 2017 Oct 31. PubMed PMID: 29068677.

3: Hughes DT, Pelletier J, Rahman S, Chen S, Leal WS, Luetje CW. Functional and Nonfunctional Forms of CquiOR91, an Odorant Selectivity Subunit of Culex quinquefasciatus. Chem Senses. 2017 May 1;42(4):333-341. doi: 10.1093/chemse/bjx011. PubMed PMID: 28334229; PubMed Central PMCID: PMC5964367.

4: Aisha Mahmood Abdulkareem AT, Selvin R. Enhanced Activity of Nanocrystalline Beta Zeolite for Acylation of Veratrole with Acetic Anhydride. J Nanosci Nanotechnol. 2016 Apr;16(4):4247-51. PubMed PMID: 27451793.

5: Lee H, Kim H, Yu MJ, Ko CH, Jeon JK, Jae J, Park SH, Jung SC, Park YK. Catalytic Hydrodeoxygenation of Bio-oil Model Compounds over Pt/HY Catalyst. Sci Rep. 2016 Jun 30;6:28765. doi: 10.1038/srep28765. PubMed PMID: 27357731; PubMed Central PMCID: PMC4928091.

6: Chang MY, Cheng YC. Synthesis of Substituted Tetralins and Benzosuberans via BF3·OEt2-Mediated Formal (4 + 2) and (5 + 2) Stereocontrolled Cycloaddition of 4-Alkenols with Veratrol. Org Lett. 2016 Feb 5;18(3):608-11. doi: 10.1021/acs.orglett.5b03696. Epub 2016 Jan 8. PubMed PMID: 26743459.

7: Artunç T, Çetinkaya Y, Göçer H, Gülçin İ, Menzek A, Şahin E, Supuran CT. Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects. Chem Biol Drug Des. 2016 Apr;87(4):594-607. doi: 10.1111/cbdd.12695. Epub 2015 Dec 29. PubMed PMID: 26642829.

8: Stubba D, Lahm G, Geffe M, Runyon JW, Arduengo AJ 3rd, Opatz T. Xylochemistry--Making Natural Products Entirely from Wood. Angew Chem Int Ed Engl. 2015 Nov 16;54(47):14187-9. doi: 10.1002/anie.201508500. Epub 2015 Oct 16. PubMed PMID: 26474300.

9: Kazakova AN, Iakovenko RO, Boyarskaya IA, Nenajdenko VG, Vasilyev AV. Acid-Promoted Reaction of Trifluoromethylated Allyl Alcohols with Arenes. Stereoselective Synthesis of CF3-Alkenes and CF3-Indanes. J Org Chem. 2015 Oct 2;80(19):9506-17. doi: 10.1021/acs.joc.5b01398. Epub 2015 Sep 30. PubMed PMID: 26334780.

10: Tentscher PR, Seidel R, Winter B, Guerard JJ, Arey JS. Exploring the aqueous vertical ionization of organic molecules by molecular simulation and liquid microjet photoelectron spectroscopy. J Phys Chem B. 2015 Jan 8;119(1):238-56. doi: 10.1021/jp508053m. Epub 2014 Dec 17. PubMed PMID: 25516011.

11: Suvitha A, Periandy S, Gayathri P. NBO, HOMO-LUMO, UV, NLO, NMR and vibrational analysis of veratrole using FT-IR, FT-Raman, FT-NMR spectra and HF-DFT computational methods. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 5;138:357-69. doi: 10.1016/j.saa.2014.11.011. Epub 2014 Nov 15. PubMed PMID: 25514662.

12: Kim JY, Cho JY, Ma YK, Lee YG, Moon JH. Nonallergenic urushiol derivatives inhibit the oxidation of unilamellar vesicles and of rat plasma induced by various radical generators. Free Radic Biol Med. 2014 Jun;71:379-89. doi: 10.1016/j.freeradbiomed.2014.03.041. Epub 2014 Apr 8. PubMed PMID: 24721153.

13: Tahara K, Akita T, Katao S, Kikuchi J. Construction of di- and tetra-ferrocenyl spiroborate complexes from catechol building blocks and their redox behaviors. Dalton Trans. 2014 Jan 21;43(3):1368-79. doi: 10.1039/c3dt52503a. Epub 2013 Nov 7. PubMed PMID: 24201444.

14: Leu WC, Hartley CS. A push-pull macrocycle with both linearly conjugated and cross-conjugated bridges. Org Lett. 2013 Jul 19;15(14):3762-5. doi: 10.1021/ol401697d. Epub 2013 Jul 10. PubMed PMID: 23841558.

15: Akhtar TA, Pichersky E. Veratrole biosynthesis in white campion. Plant Physiol. 2013 May;162(1):52-62. doi: 10.1104/pp.113.214346. Epub 2013 Apr 1. PubMed PMID: 23547102; PubMed Central PMCID: PMC3641228.

16: Akbaba Y, Türkeş C, Polat L, Söyüt H, Sahin E, Menzek A, Göksu S, Beydemir S. Synthesis and paroxonase activities of novel bromophenols. J Enzyme Inhib Med Chem. 2013 Oct;28(5):1073-9. doi: 10.3109/14756366.2012.715287. Epub 2012 Sep 20. PubMed PMID: 22994801.

17: Gupta AK, Akhtar TA, Widmer A, Pichersky E, Schiestl FP. Identification of white campion (Silene latifolia) guaiacol O-methyltransferase involved in the biosynthesis of veratrole, a key volatile for pollinator attraction. BMC Plant Biol. 2012 Aug 31;12:158. doi: 10.1186/1471-2229-12-158. PubMed PMID: 22937972; PubMed Central PMCID: PMC3492160.

18: Herken EN, Celik A, Aslan M, Aydınlık N. The constituents of essential oil: antimicrobial and antioxidant activity of Micromeria congesta Boiss. & Hausskn. ex Boiss. from East Anatolia. J Med Food. 2012 Sep;15(9):835-9. doi: 10.1089/jmf.2011.0315. Epub 2012 Aug 7. PubMed PMID: 22871061.

19: Inokuchi Y, Boyarkin OV, Ebata T, Rizzo TR. UV and IR spectroscopy of cold 1,2-dimethoxybenzene complexes with alkali metal ions. Phys Chem Chem Phys. 2012 Apr 7;14(13):4457-62. doi: 10.1039/c2cp24018a. Epub 2012 Feb 22. PubMed PMID: 22354005.

20: Breyer S, Effenberger-Neidnicht K, Knauer S, Schobert R. Synthesis, anticancer activity, and iron affinity of the Actinoplanes metabolite 7,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione. Bioorg Med Chem. 2011 Feb 1;19(3):1264-7. doi: 10.1016/j.bmc.2010.12.012. Epub 2010 Dec 9. PubMed PMID: 21216607.