WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591756

CAS#: 94-09-7

Description: Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

Price and Availability


USD 240

USD 500

Benzocaine; purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 591756
Name: Benzocaine
CAS#: 94-09-7
Chemical Formula: C9H11NO2
Exact Mass: 165.079
Molecular Weight: 165.19
Elemental Analysis: C, 65.44; H, 6.71; N, 8.48; O, 19.37

Synonym: Benzocaine; NSC 41531; NSC-41531; NSC41531

IUPAC/Chemical Name: Benzoic acid, 4-amino-, ethyl ester


InChi Code: InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: From Benzene Rings to Political Ones: Metz and His Benzocaine, Anaesthesine. Anesthesiology. 2018 Jul;129(1):36. doi: 10.1097/ALN.0000000000002302. PubMed PMID: 29916910.

2: Khanal S, Modi R, Akhtar K, Ghimire A. Benzocaine-Associated Methemoglobinemia. Am J Ther. 2018 Jun 15. doi: 10.1097/MJT.0000000000000782. [Epub ahead of print] PubMed PMID: 29912717.

3: de Souza Romaneli R, Boaratti AZ, Tellechea Rodrigues A, de Almeida Ueiroz DM, Khan KU, Nascimento TMT, Fernandes JBK. Efficacy of Benzocaine, Eugenol and Menthol as Anesthetics for Freshwater Angelfish (Pterophyllum scalare). J Aquat Anim Health. 2018 May 29. doi: 10.1002/aah.10030. [Epub ahead of print] PubMed PMID: 29845639.

4: Gondim DGA, Montagner AM, Pita-Neto IC, Bringel RJS, Sandrini FAL, Moreno EFC, de Sousa AM, Correia AB. Comparative Analysis of the Effectiveness of the Topical Administration of Benzocaine and EMLA(®) on Oral Pain and Tactile Sensitivity. Int J Dent. 2018 Feb 7;2018:7916274. doi: 10.1155/2018/7916274. eCollection 2018. PubMed PMID: 29593794; PubMed Central PMCID: PMC5821963.

5: Smith BD, Vail KJ, Carroll GL, Taylor MC, Jeffery ND, Vemulapalli TH, Elliott JJ. Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus laevis). J Am Assoc Lab Anim Sci. 2018 Mar 1;57(2):202-209. PubMed PMID: 29555009; PubMed Central PMCID: PMC5868386.

6: Abin-Carriquiry JA, Martínez-Busi M, Galvalisi M, Minteguiaga M, Prieto JP, Scorza MC. Identification and Quantification of Cocaine and Active Adulterants in Coca-Paste Seized Samples: Useful Scientific Support to Health Care. Neurotox Res. 2018 Mar 13. doi: 10.1007/s12640-018-9887-1. [Epub ahead of print] PubMed PMID: 29536266.

7: Ford LT, Berg JD. Analytical evidence to show letters impregnated with novel psychoactive substances are a means of getting drugs to inmates within the UK prison service. Ann Clin Biochem. 2018 Jan 1:4563218767462. doi: 10.1177/0004563218767462. [Epub ahead of print] PubMed PMID: 29534614.

8: Saporito RA, Grant T. Comment on Amézquita et al. (2017) "Conspicuousness, color resemblance, and toxicity in geographically diverging mimicry: The pan-Amazonian frog Allobates femoralis". Evolution. 2018 Apr;72(4):1009-1014. doi: 10.1111/evo.13468. Epub 2018 Mar 25. PubMed PMID: 29524217.

9: Ljubojević Hadžavdić S, Gojčeta Burnić S, Hadžavdić A, Marinović Kulišić S, Jurakić Tončić R. Erythema of the penis after use of a latex condom - latex allergy or something else? Contact Dermatitis. 2018 Feb;78(2):168-169. doi: 10.1111/cod.12879. PubMed PMID: 29341187.

10: Mangiapia G, Gvaramia M, Kuhrts L, Teixeira J, Koutsioubas A, Soltwedel O, Frielinghaus H. Effect of benzocaine and propranolol on phospholipid-based bilayers. Phys Chem Chem Phys. 2017 Dec 6;19(47):32057-32071. doi: 10.1039/c7cp06077g. PubMed PMID: 29181470.

11: Ip EJ, Patel PB, Chi JJ, Shah-Manek B, Lau B. What are pharmacists recommending for infant teething treatment? J Am Pharm Assoc (2003). 2018 Jan - Feb;58(1):79-83.e1. doi: 10.1016/j.japh.2017.10.009. Epub 2017 Nov 15. PubMed PMID: 29153854.

12: da Silva EB, da Silva Corrêa SA, de Souza Abessa DM, da Silva BFX, Rivero DHRF, Seriani R. Mucociliary transport, differential white blood cells, and cyto-genotoxicity in peripheral erythrocytes in fish from a polluted urban pond. Environ Sci Pollut Res Int. 2018 Jan;25(3):2683-2690. doi: 10.1007/s11356-017-0729-0. Epub 2017 Nov 13. PubMed PMID: 29134526.

13: Kaufman MR, Aouad RK. Benzocaine-Induced Methemoglobinemia. J Emerg Med. 2017 Dec;53(6):912-913. doi: 10.1016/j.jemermed.2017.09.004. Epub 2017 Nov 6. PubMed PMID: 29102098.

14: Gibbs S, Kosten I, Veldhuizen R, Spiekstra S, Corsini E, Roggen E, Rustemeyer T, Feilzer AJ, Kleverlaan CJ. Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay. Toxicology. 2018 Jan 15;393:62-72. doi: 10.1016/j.tox.2017.10.014. Epub 2017 Oct 25. PubMed PMID: 29079364.

15: Thygesen MM, Rasmussen MM, Madsen JG, Pedersen M, Lauridsen H. Propofol (2,6-diisopropylphenol) is an applicable immersion anesthetic in the axolotl with potential uses in hemodynamic and neurophysiological experiments. Regeneration (Oxf). 2017 Jul 27;4(3):124-131. doi: 10.1002/reg2.80. eCollection 2017 Jun. PubMed PMID: 28975032; PubMed Central PMCID: PMC5617899.

16: Wang S, Giannakopoulos H, Lowstetter J, Kaye L, Lee C, Secreto S, Ho V, Hutcheson MC, Farrar JT, Wang P, Doyle G, Cooper SA, Hersh EV. Lack of Methemoglobin Elevations After Topical Applications of Benzocaine Alone or Benzocaine Plus Tetracaine to the Oral Mucosa. Clin Ther. 2017 Oct;39(10):2103-2108. doi: 10.1016/j.clinthera.2017.08.017. Epub 2017 Sep 22. PubMed PMID: 28943117.

17: Xia H, Attygalle AB. Untrapping Kinetically Trapped Ions: The Role of Water Vapor and Ion-Source Activation Conditions on the Gas-Phase Protomer Ratio of Benzocaine Revealed by Ion-Mobility Mass Spectrometry. J Am Soc Mass Spectrom. 2017 Dec;28(12):2580-2587. doi: 10.1007/s13361-017-1806-9. Epub 2017 Sep 21. PubMed PMID: 28936768.

18: Hutterer R. Inclusion of fluorophores in cyclodextrins: a closer look at the fluorometric determination of association constants by linear and nonlinear fitting procedures. Methods Appl Fluoresc. 2017 Dec 13;6(1):013001. doi: 10.1088/2050-6120/aa8d96. PubMed PMID: 28925371.

19: Lee HS. Recent advances in topical anesthesia. J Dent Anesth Pain Med. 2016 Dec;16(4):237-244. doi: 10.17245/jdapm.2016.16.4.237. Epub 2016 Dec 31. Review. PubMed PMID: 28879311; PubMed Central PMCID: PMC5564188.

20: Vohra R, Huntington S, Koike J, Le K, Geller RJ. Pediatric Exposures to Topical Benzocaine Preparations Reported to a Statewide Poison Control System. West J Emerg Med. 2017 Aug;18(5):923-927. doi: 10.5811/westjem.2017.6.33665. Epub 2017 Jul 14. PubMed PMID: 28874945; PubMed Central PMCID: PMC5576629.