WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563099
CAS#: 333415-38-6
Description: VU0071063 is an activator of Kir6.2/SUR1.
MedKoo Cat#: 563099
Name: VU0071063
CAS#: 333415-38-6
Chemical Formula: C18H22N4O2
Exact Mass: 326.1743
Molecular Weight: 326.4
Elemental Analysis: C, 66.24; H, 6.79; N, 17.17; O, 9.80
Synonym: VU0071063; VU-0071063; VU 0071063;
IUPAC/Chemical Name: 7-(4-(tert-Butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
InChi Key: ZFZAIHKQJBMYLO-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
SMILES Code: O=C(N1C)N(C)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 326.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol Pharmacol. 2014 Jun;85(6):858-65. doi: 10.1124/mol.114.091884. Epub 2014 Mar 19. PubMed PMID: 24646456; PubMed Central PMCID: PMC4014665.
