A22 hydrochloride
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MedKoo CAT#: 555259

CAS#: 22816-60-0 (HCl)

Description: A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.


Price and Availability

Size
Price

10mg
USD 245
Size
Price

50mg
USD 650
Size
Price

A22 hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555259
Name: A22 hydrochloride
CAS#: 22816-60-0 (HCl)
Chemical Formula: C8H9Cl3N2S
Exact Mass:
Molecular Weight: 271.584
Elemental Analysis: C, 35.38; H, 3.34; Cl, 39.16; N, 10.32; S, 11.80


Related CAS #: 22816-60-0 (HCl)    

Synonym: MreB Perturbing Compound A22; A22 hydrochloride.

IUPAC/Chemical Name: S-(3,4-Dichlorobenzyl)isothiourea hydrochloride

InChi Key: VBJNMXMOMSWRDV-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H

SMILES Code: N=C(N)SCC1=CC=C(Cl)C(Cl)=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bonez PC, Rossi GG, Bandeira JR, Ramos AP, Mizdal CR, Agertt VA, Dalla Nora
ESS, de Souza ME, Dos Santos Alves CF, Dos Santos FS, Gündel A, de Almeida
Vaucher R, Santos RCV, de Campos MMA. Anti-biofilm activity of A22
((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas
aeruginosa: Influence on biofilm formation, motility and bioadhesion. Microb
Pathog. 2017 Oct;111:6-13. doi: 10.1016/j.micpath.2017.08.008. Epub 2017 Aug 10.
PubMed PMID: 28804018.

2: Bonez PC, Ramos AP, Nascimento K, Copetti PM, Souza ME, Rossi GG, Agertt VA,
Sagrillo MR, Santos RC, Campos MM. Antibacterial, cyto and genotoxic activities
of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride). Microb
Pathog. 2016 Oct;99:14-18. doi: 10.1016/j.micpath.2016.07.007. Epub 2016 Jul 16.
PubMed PMID: 27427089.

3: Nicholson A, Perry JD, James AL, Stanforth SP, Carnell S, Wilkinson K, Anjam
Khan CM, De Soyza A, Gould FK. In vitro activity of
S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related
compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa
and Burkholderia cepacia complex. Int J Antimicrob Agents. 2012 Jan;39(1):27-32.
doi: 10.1016/j.ijantimicag.2011.08.015. Epub 2011 Oct 10. PubMed PMID: 21993484.