Azidamfenicol
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MedKoo CAT#: 584462

CAS#: 13838-08-9

Description: Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic that is active against Gram-negative and Gram-positive bacteria. It inhibits ribosomal peptidyltransferase.


Chemical Structure

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Azidamfenicol
CAS# 13838-08-9

Theoretical Analysis

MedKoo Cat#: 584462
Name: Azidamfenicol
CAS#: 13838-08-9
Chemical Formula: C11H13N5O5
Exact Mass: 295.09
Molecular Weight: 295.255
Elemental Analysis: C, 44.75; H, 4.44; N, 23.72; O, 27.09

Price and Availability

Size Price Availability Quantity
5mg USD 150 Ready to ship
10mg USD 250 Ready to ship
25mg USD 450 Ready to ship
50mg USD 750 Ready to ship
100mg USD 1350 Ready to ship
200mg USD 2250 Ready to ship
Bulk inquiry

Synonym: Bay f 4797; Bayer 52910; Bayer52910; Bayer-52910; Bay 52910; Bay52910; Bay-52910; Leukomycin N; (-)-Azidamphenicol; Azidamfenicol; Azidamphenicol;

IUPAC/Chemical Name: 2-azido-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamide

InChi Key: SGRUZFCHLOFYHZ-MWLCHTKSSA-N

InChi Code: InChI=1S/C11H13N5O5/c12-15-13-5-10(18)14-9(6-17)11(19)7-1-3-8(4-2-7)16(20)21/h1-4,9,11,17,19H,5-6H2,(H,14,18)/t9-,11-/m1/s1

SMILES Code: O=C(N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)CN=[N+]=[N-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic. Azidamfenicol inhibits ribosomal peptidyltransferase (Ki=22 µM).
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 295.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Zhang L, Toplak M, Saleem-Batcha R, Höing L, Jakob R, Jehmlich N, von Bergen M, Maier T, Teufel R. Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol. Chembiochem. 2023 Jan 17;24(2):e202200632. doi: 10.1002/cbic.202200632. Epub 2022 Dec 5. PMID: 36353978.


2: Raulin C, Frosch PJ. Kontaktallergie auf Clotrimazol und Azidamfenicol [Contact allergy to clotrimazole and azidamfenicol]. Derm Beruf Umwelt. 1987 Mar-Apr;35(2):64-6. German. PMID: 2954808.


3: Bedair MM, Korany MA, Elsayed MA, Fahmy OT. Derivative spectrophotometric determination of clotrimazole in single formulations and in combination with other drugs. J Assoc Off Anal Chem. 1989 May-Jun;72(3):432-5. PMID: 2745365.


4: Poitschek C, Thurner J, Haller I. Bestimmung der antimikrobiellen Wirksamkeit einer Kombination aus Azidamfenicol, Clotrimazol und Dexamethason in vitro [Determination of antimicrobial activity of a combination of acidamfenicol, clotrimazole and dexamethasone in vitro (author's transl)]. Arzneimittelforschung. 1978;28(2):232-4. German. PMID: 580383.


5: Polkowska M, Urbanska Z, Wolowa F. Baycuten und Baycuten SD. Wirking und Verträglichkeit [Baycuten and baycuten SD. Effect and tolerance]. Med Welt. 1982 Apr 8;33(14):525-9. German. PMID: 7087733.


6: Polkowska M. Kliniczna ocena preparatów Baycuten i Baycuten SD firmy Bayer [Clinical evaluation of the preparations Baycuten and Baycuten SD produced by Bayer]. Przegl Dermatol. 1984 Sep-Oct;71(5):483-6. Polish. PMID: 6396736.