p-Aminophenol hydrochloride

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591631

CAS#: 51-78-5

Description: p-Aminophenol hydrochloride is a biochemical.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

p-Aminophenol hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 591631
Name: p-Aminophenol hydrochloride
CAS#: 51-78-5
Chemical Formula: C6H8ClNO
Exact Mass: 145.0294
Molecular Weight: 145.59
Elemental Analysis: C, 49.50; H, 5.54; Cl, 24.35; N, 9.62; O, 10.99

Synonym: p-Aminophenol hydrochloride; AI3-00317; AI3 00317; AI300317

IUPAC/Chemical Name: 4-Hydroxyanilinium chloride


InChi Code: InChI=1S/C6H7NO.ClH/c7-5-1-3-6(8)4-2-5;/h1-4,8H,7H2;1H

SMILES Code: [NH3+]C1=CC=C(O)C=C1.[Cl-]

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Zhao PF, Liu ZQ. 2-Isocyano glucose used in Ugi four-component reaction: An approach to enhance inhibitory effect against DNA oxidation. Eur J Med Chem. 2017 Jul 28;135:458-466. doi: 10.1016/j.ejmech.2017.04.041. Epub 2017 Apr 18. PubMed PMID: 28475973.

2: Martins AC, Ribeiro FW, Zanatta G, Freire VN, Morais S, de Lima-Neto P, Correia AN. Modeling of laccase inhibition by formetanate pesticide using theoretical approaches. Bioelectrochemistry. 2016 Apr;108:46-53. doi: 10.1016/j.bioelechem.2015.12.004. Epub 2015 Dec 21. PubMed PMID: 26720841.

3: Zhao M, Kamada T, Takeuchi A, Nishioka H, Kuroda T, Takeuchi Y. Structure-activity relationship of indoloquinoline analogs anti-MRSA. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5551-4. doi: 10.1016/j.bmcl.2015.10.058. Epub 2015 Oct 21. PubMed PMID: 26522949.

4: Wang M, Yu H, Li P, Li J, Gao Y. [Determination of piperidinium ionic liquid cations by ion-pair chromatography-indirect ultraviolet detection]. Se Pu. 2014 Jul;32(7):773-8. Chinese. PubMed PMID: 25255572.

5: Vojta J, Hanzlík P, Jedlička A, Coufal P. Separation and determination of impurities in paracetamol, codeine and pitophenone in the presence of fenpiverinium in combined suppository dosage form. J Pharm Biomed Anal. 2015 Jan;102:85-92. doi: 10.1016/j.jpba.2014.09.002. Epub 2014 Sep 16. PubMed PMID: 25255449.

6: Oliveira TM, Barroso MF, Morais S, Araújo M, Freire C, de Lima-Neto P, Correia AN, Oliveira MB, Delerue-Matos C. Sensitive bi-enzymatic biosensor based on polyphenoloxidases-gold nanoparticles-chitosan hybrid film-graphene doped carbon paste electrode for carbamates detection. Bioelectrochemistry. 2014 Aug;98:20-9. doi: 10.1016/j.bioelechem.2014.02.003. Epub 2014 Mar 5. PubMed PMID: 24642204.

7: Sun Y, Yu H. [Rapid determination of N-methyl, propyl-morpholinium cation by ion-pair chromatography on monolithic column with indirect ultraviolet detection]. Se Pu. 2013 Oct;31(10):969-73. Chinese. PubMed PMID: 24432639.

8: Schwensen JF, Johansen JD, Veien NK, Funding AT, Avnstorp C, Osterballe M, Andersen KE, Paulsen E, Mortz CG, Sommerlund M, Danielsen A, Andersen BL, Thormann J, Kristensen O, Kristensen B, Vissing S, Nielsen NH, Thyssen JP, Søsted H. Occupational contact dermatitis in hairdressers: an analysis of patch test data from the Danish contact dermatitis group, 2002-2011. Contact Dermatitis. 2014 Apr;70(4):233-7. doi: 10.1111/cod.12176. Epub 2013 Dec 26. PubMed PMID: 24372565.

9: Tomishima Y, Ishitsuka Y, Matsunaga N, Nagatome M, Furusho H, Irikura M, Ohdo S, Irie T. Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice. BMC Gastroenterol. 2013 Jan 30;13:21. doi: 10.1186/1471-230X-13-21. PubMed PMID: 23363429; PubMed Central PMCID: PMC3568068.

10: Rodrigues GD, de Lemos LR, Patrício Pda R, da Silva LH, da Silva Mdo C. Aqueous two-phase systems: a new approach for the determination of p-aminophenol. J Hazard Mater. 2011 Aug 15;192(1):292-8. doi: 10.1016/j.jhazmat.2011.05.023. Epub 2011 May 14. PubMed PMID: 21632175.

11: Darwish IA, Hussein SA, Mahmoud AM, Hassan AI. A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol. Acta Pharm. 2008 Mar;58(1):87-97. doi: 10.2478/v10007-007-0047-z. PubMed PMID: 18337210.

12: Bomhard EM, Herbold BA. Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats. Crit Rev Toxicol. 2005 Dec;35(10):783-835. Review. PubMed PMID: 16468500.

13: Marín A, Barbas C. Systematic comparison of different functionality columns for a classical pharmaceutical problem. J Pharm Biomed Anal. 2006 Feb 13;40(2):262-70. Epub 2005 Sep 16. PubMed PMID: 16146679.

14: Olmo B, García A, Marín A, Barbas C. New approaches with two cyano columns to the separation of acetaminophen, phenylephrine, chlorpheniramine and related compounds. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Mar 25;817(2):159-65. PubMed PMID: 15686980.

15: Jindal DP, Coumar MS, Bruni G, Massarelli P. Synthesis and beta 1-, beta 2-adrenergic receptor binding studies of 4-acylamino-substituted phenoxypropanolamine and 5-acylamino-substituted naphthyloxypropanolamine derivatives. Arzneimittelforschung. 2002;52(9):654-63. PubMed PMID: 12404879.

16: Rankin GO, Beers KW, Nicoll DW, Anestis DK, Hong SK, Hubbard JL, Ball JG, Valentovic MA, Brown PI. Nephrotoxic potential of 2-amino-5-chlorophenol and 4-amino-3-chlorophenol in Fischer 344 rats: comparisons with 2- and 4-chloroaniline and 2- and 4-aminophenol. Toxicology. 1996 Apr 15;108(1-2):109-23. PubMed PMID: 8644109.

17: Khalaf KD, Sancenon J, de la Guardia M. Spectrophotometric flow injection determination of formetanate and m-aminophenol in water after reaction with p-aminophenol. Talanta. 1993 Aug;40(8):1173-81. PubMed PMID: 18965765.

18: Kanaya N. Induction of chromosome damage by aniline and its C-hydroxylated metabolites in the root cells of Vicia faba. Mutat Res. 1990 Dec;245(4):311-5. PubMed PMID: 2266983.

19: Burnett CM, Goldenthal EI. Multigeneration reproduction and carcinogenicity studies in Sprague-Dawley rats exposed topically to oxidative hair-colouring formulations containing p-phenylenediamine and other aromatic amines. Food Chem Toxicol. 1988 May;26(5):467-74. PubMed PMID: 3391471.

20: Wu WN, Hills JF, Chang SY, Ng KT. Metabolism of bepridil in laboratory animals and humans. Drug Metab Dispos. 1988 Jan-Feb;16(1):69-77. PubMed PMID: 2894958.