Lysine HCl

We are open as normal in holiday season. We are closed in Dec 24, Dec 25 and Jan 1.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597088

CAS#: 657-27-2 (HCl)

Description: Lysine HCl is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain lysyl ((CH2)4NH2), classifying it as a basic, charged (at physiological pH), aliphatic amino acid. It is encoded by the codons, AAA and AAG. Like almost all other amino acids, the α-carbon is chiral and lysine may refer to either enantiomer or a racemic mixture of both.

Price and Availability

Size Price Shipping out time Quantity
100g USD 300 2 Weeks
1kg USD 1140 2 Weeks
5kg USD 3950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-12-05. Prices are subject to change without notice.

Lysine HCl purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 597088
Name: Lysine HCl
CAS#: 657-27-2 (HCl)
Chemical Formula: C6H15ClN2O2
Exact Mass:
Molecular Weight: 182.64
Elemental Analysis: C, 39.46; H, 8.28; Cl, 19.41; N, 15.34; O, 17.52

Synonym: Lysine hydrochloride; L-Lysine monohydrochloride; Lysine HCl; L-Gen; Lyamine;

IUPAC/Chemical Name: L-lysine hydrochloride


InChi Code: InChI=1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Nunes V, Niinikoski H. Lysinuric Protein Intolerance. 2006 Dec 21 [updated 2018 Apr 12]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from PubMed PMID: 20301535.

2: Greiner L, Srichana P, Usry JL, Neill C, Allee GL, Connor J, Touchette KJ, Knight CD. The use of feed-grade amino acids in lactating sow diets. J Anim Sci Biotechnol. 2018 Jan 12;9:3. doi: 10.1186/s40104-017-0223-z. eCollection 2018. PubMed PMID: 29344352; PubMed Central PMCID: PMC5765693.

3: Waghorn PA, Oliveira BL, Jones CM, Tager AM, Caravan P. High sensitivity HPLC method for determination of the allysine concentration in tissue by use of a naphthol derivative. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Oct 1;1064:7-13. doi: 10.1016/j.jchromb.2017.08.032. Epub 2017 Aug 26. PubMed PMID: 28886479; PubMed Central PMCID: PMC5662445.

4: Anaya-Reza O, Lopez-Arenas T. Comprehensive assessment of the L-lysine production process from fermentation of sugarcane molasses. Bioprocess Biosyst Eng. 2017 Jul;40(7):1033-1048. doi: 10.1007/s00449-017-1766-2. Epub 2017 Apr 13. PubMed PMID: 28409400.

5: Zhang C, Pan D, Li J, Hu J, Bains A, Guys N, Zhu H, Li X, Luo K, Gong Q, Gu Z. Enzyme-responsive peptide dendrimer-gemcitabine conjugate as a controlled-release drug delivery vehicle with enhanced antitumor efficacy. Acta Biomater. 2017 Jun;55:153-162. doi: 10.1016/j.actbio.2017.02.047. Epub 2017 Mar 2. PubMed PMID: 28259838.

6: Tayade AB, Dhar P, Kumar J, Sharma M, Chaurasia OP, Srivastava RB. Trans-Himalayan Rhodiola imbricata Edgew. root: a novel source of dietary amino acids, fatty acids and minerals. J Food Sci Technol. 2017 Feb;54(2):359-367. doi: 10.1007/s13197-016-2469-4. Epub 2017 Jan 30. PubMed PMID: 28242935; PubMed Central PMCID: PMC5306029.

7: Vivijs B, Aertsen A, Michiels CW. Identification of Genes Required for Growth of Escherichia coli MG1655 at Moderately Low pH. Front Microbiol. 2016 Oct 25;7:1672. eCollection 2016. PubMed PMID: 27826291; PubMed Central PMCID: PMC5078493.

8: Hochheim J, Kranz A, Krumbach K, Sokolowsky S, Eggeling L, Noack S, Bocola M, Bott M, Marienhagen J. Mutations in MurE, the essential UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase of Corynebacterium glutamicum: effect on L-lysine formation and analysis of systemic consequences. Biotechnol Lett. 2017 Feb;39(2):283-288. doi: 10.1007/s10529-016-2243-8. Epub 2016 Oct 25. PubMed PMID: 27783176.

9: Hwang HJ, Dornbos P, LaPres JJ. Data on AHR-dependent changes in the mitochondrial proteome in response to ,3,7,8-tetrachlorodibenzo-p-dioxin. Data Brief. 2016 May 20;8:191-5. doi: 10.1016/j.dib.2016.05.023. eCollection 2016 Sep. PubMed PMID: 27331086; PubMed Central PMCID: PMC4898910.

10: Cremades A, Del Rio-Garcia J, Lambertos A, López-Garcia C, Peñafiel R. Tissue-specific regulation of potassium homeostasis by high doses of cationic amino acids. Springerplus. 2016 May 13;5:616. doi: 10.1186/s40064-016-2224-3. eCollection 2016. PubMed PMID: 27330882; PubMed Central PMCID: PMC4870509.

11: Colina JJ, Miller PS, Lewis AJ, Fischer RL, Diedrichsen RM. Body composition, tissue deposition, and lysine utilization for protein deposition of barrows and gilts fed crystalline or protein-bound lysine. J Anim Sci. 2016 May;94(5):1972-81. doi: 10.2527/jas.2015-0190. PubMed PMID: 27285695.

12: McClelland LJ, Bowler BE. Lower Protein Stability Does Not Necessarily Increase Local Dynamics. Biochemistry. 2016 May 17;55(19):2681-93. doi: 10.1021/acs.biochem.5b01060. Epub 2016 May 4. PubMed PMID: 27104373.

13: Takaoka A, Babar N, Hogan J, Kim M, Price MO, Price FW Jr, Trokel SL, Paik DC. An Evaluation of Lysyl Oxidase-Derived Cross-Linking in Keratoconus by Liquid Chromatography/Mass Spectrometry. Invest Ophthalmol Vis Sci. 2016 Jan 1;57(1):126-36. doi: 10.1167/iovs.15-18105. PubMed PMID: 26780316; PubMed Central PMCID: PMC4727527.

14: Kugimiya A, Konishi H, Fukada R. Flow Analysis of Amino Acids by Using a Newly Developed Aminoacyl-tRNA Synthetase-Immobilized, Small Reactor Column-Based Assay. Appl Biochem Biotechnol. 2016 Mar;178(5):924-31. doi: 10.1007/s12010-015-1918-2. Epub 2015 Nov 10. PubMed PMID: 26554858.

15: Dee S, Neill C, Clement T, Singrey A, Christopher-Hennings J, Nelson E. An evaluation of porcine epidemic diarrhea virus survival in individual feed ingredients in the presence or absence of a liquid antimicrobial. Porcine Health Manag. 2015 Jul 9;1:9. doi: 10.1186/s40813-015-0003-0. eCollection 2015. PubMed PMID: 28405416; PubMed Central PMCID: PMC5382523.

16: Testoni B, Durantel D, Lebossé F, Fresquet J, Helle F, Negro F, Donato MF, Levrero M, Zoulim F. Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. Gut. 2016 Apr;65(4):672-82. doi: 10.1136/gutjnl-2014-309011. Epub 2015 Jun 16. PubMed PMID: 26082258.

17: Mehri M, Bagherzadeh Kasmani F, Asghari-Moghadam M. Estimation of lysine requirements of growing Japanese quail during the fourth and fifth weeks of age. Poult Sci. 2015 Aug;94(8):1923-7. doi: 10.3382/ps/pev153. Epub 2015 Jun 11. PubMed PMID: 26069252.

18: Yang Y, Wu Z, Jia S, Dahanayaka S, Feng S, Meininger CJ, McNeal CJ, Wu G. Safety of long-term dietary supplementation with L-arginine in rats. Amino Acids. 2015 Sep;47(9):1909-20. doi: 10.1007/s00726-015-1992-3. Epub 2015 May 7. PubMed PMID: 25948162.

19: Kroeckel S, Dietz C, Schulz C, Susenbeth A. Bioavailability of free lysine and protein-bound lysine from casein and fishmeal in juvenile turbot (Psetta maxima). Br J Nutr. 2015 Mar 14;113(5):718-27. doi: 10.1017/S000711451400381X. Epub 2015 Feb 16. PubMed PMID: 25683818.

20: Hadj Ammar H, Lajili S, Ben Said R, Le Cerf D, Bouraoui A, Majdoub H. Physico-chemical characterization and pharmacological evaluation of sulfated polysaccharides from three species of Mediterranean brown algae of the genus Cystoseira. Daru. 2015 Jan 13;23:1. doi: 10.1186/s40199-015-0089-6. PubMed PMID: 25582169; PubMed Central PMCID: PMC4298055.