WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558188
CAS#: 2507-91-7
Description: Gloxazone is an effective but toxic anaplasmacide.
MedKoo Cat#: 558188
Name: Gloxazone
CAS#: 2507-91-7
Chemical Formula: C8H16N6OS2
Exact Mass: 276.08
Molecular Weight: 276.38
Elemental Analysis: C, 34.77; H, 5.84; N, 30.41; O, 5.79; S, 23.20
Synonym: 356C61; BW 356C61; BW356C61; BW-356C61; Contrapar; Gloxazon; Gloxazone; NSC 82116; NSC-82116; NSC82116; U 7726; U-7726; U7726; WR 9838; WR9838; WR-9838;
IUPAC/Chemical Name: Butyraldehyde, 3-ethoxy-2-oxo-, bis(thiosemicarbazone)
InChi Key: ARIFZLJIERKKEL-SNNHKCHZSA-N
InChi Code: InChI=1S/C8H16N6OS2/c1-3-15-5(2)6(12-14-8(10)17)4-11-13-7(9)16/h4-5H,3H2,1-2H3,(H3,9,13,16)(H3,10,14,17)/b11-4+,12-6-
SMILES Code: CC(OCC)C(/C=N/NC(N)=S)=N\NC(N)=S
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 276.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: McHardy N, Berger J, Taylor RJ, Farebrother D, James JA. Comparison of gloxazone, an effective but toxic anaplasmacide, with imidocarb dihydrochloride. Res Vet Sci. 1980 Sep;29(2):198-202. PubMed PMID: 6451008.
2: Du Plessis JL. The influence of dithiosemicarbazone on the immunity of sheep to heartwater. Onderstepoort J Vet Res. 1981 Sep;48(3):175-6. PubMed PMID: 7335333.
3: Du Plessis JL, Berche P, Van Gas L. T cell-mediated immunity to Cowdria ruminantium in mice: the protective role of Lyt-2+ T cells. Onderstepoort J Vet Res. 1991 Sep;58(3):171-9. PubMed PMID: 1923379.
4: Wassink LA, Franssen FF, Uilenberg G, Perié NM. Observations on mouse-infective stocks of Cowdria ruminantium: attempts to demonstrate persistence of the organism in mice immune to the Kwanyanga stock. Res Vet Sci. 1987 Jan;42(1):65-7. PubMed PMID: 2950579.
