Xanthone
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591577

CAS#: 90-47-1

Description: Xanthone was introduced as an insecticide and it currently finds uses as ovicide for codling moth eggs and as a larvicide. Xanthone is also used in the preparation of xanthydrol, which is used in the determination of urea levels in the blood.


Price and Availability

Size
Price

25g
USD 250
Size
Price

Size
Price

Xanthone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 591577
Name: Xanthone
CAS#: 90-47-1
Chemical Formula: C13H8O2
Exact Mass: 196.0524
Molecular Weight: 196.21
Elemental Analysis: C, 79.58; H, 4.11; O, 16.31


Synonym: Xanthone; NSC 14978; NSC-14978; NSC14978

IUPAC/Chemical Name: 9H-Xanthen-9-one

InChi Key: JNELGWHKGNBSMD-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H8O2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H

SMILES Code: O=C1C2=C(OC3=C1C=CC=C3)C=CC=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Herder M, Lehn JM. The Photodynamic Covalent Bond: Sensitized Alkoxyamines as a Tool To Shift Reaction Networks Out-of-Equilibrium Using Light Energy. J Am Chem Soc. 2018 Jun 12. doi: 10.1021/jacs.8b03633. [Epub ahead of print] PubMed PMID: 29893123.

2: Wang P, Jiang L, Cao Y, Ye D, Zhou L. The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors. Molecules. 2018 Jun 8;23(6). pii: E1396. doi: 10.3390/molecules23061396. PubMed PMID: 29890679.

3: Park SJ, Park BS, Yu SB, Kang HM, Kim HJ, Kim IR. Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by α-Mangostin in MG-63 Cell Lines. Evid Based Complement Alternat Med. 2018 Apr 26;2018:3985082. doi: 10.1155/2018/3985082. eCollection 2018. PubMed PMID: 29853951; PubMed Central PMCID: PMC5944198.

4: Patra N, Dehury N, Pal A, Behera A, Patra S. Preparation and mechanistic aspect of natural xanthone functionalized gold nanoparticle. Mater Sci Eng C Mater Biol Appl. 2018 Sep 1;90:439-445. doi: 10.1016/j.msec.2018.04.091. Epub 2018 May 1. PubMed PMID: 29853110.

5: Castillo-Arellano JI, Guzmán-Gutiérrez SL, Ibarra-Sánchez A, Hernández-Ortega S, Nieto-Camacho A, Medina-Campos ON, Pedraza-Chaverri J, Reyes-Chilpa R, González-Espinosa C. Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells. Biochem Pharmacol. 2018 May 24;154:344-356. doi: 10.1016/j.bcp.2018.05.002. [Epub ahead of print] PubMed PMID: 29802828.

6: Ibrahim SRM, El-Agamy DS, Abdallah HM, Ahmed N, Elkablawy MA, Mohamed GA. Protective activity of tovophyllin A, a xanthone isolated from Garcinia mangostana pericarps, against acetaminophen-induced liver damage: role of Nrf2 activation. Food Funct. 2018 May 23. doi: 10.1039/c8fo00378e. [Epub ahead of print] PubMed PMID: 29790527.

7: Koh JJ, Lin S, Bai Y, Sin WWL, Aung TT, Li J, Chandra V, Pervushin K, Beuerman RW, Liu S. Antimicrobial activity profiles of Amphiphilic Xanthone derivatives are a function of their molecular Oligomerization. Biochim Biophys Acta. 2018 May 18. pii: S0005-2736(18)30148-2. doi: 10.1016/j.bbamem.2018.05.006. [Epub ahead of print] PubMed PMID: 29782818.

8: Ding SM, Lan T, Ye GJ, Huang JJ, Hu Y, Zhu YR, Wang B. Novel oxazolxanthone derivatives as a new type of α-glucosidase inhibitor: synthesis, activities, inhibitory modes and synergetic effect. Bioorg Med Chem. 2018 May 15. pii: S0968-0896(18)30583-2. doi: 10.1016/j.bmc.2018.05.008. [Epub ahead of print] PubMed PMID: 29776833.

9: Lee D, Kim YM, Jung K, Chin YW, Kang KS. Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage. Int J Mol Sci. 2018 May 16;19(5). pii: E1484. doi: 10.3390/ijms19051484. PubMed PMID: 29772703; PubMed Central PMCID: PMC5983655.

10: Timsina B, Kindlmann P, Rokaya MB, Vrchotová N, Tříska J, Horník Š, Sýkora J. Xanthones Content in Swertia multicaulis D. Don from Nepal. Molecules. 2018 May 3;23(5). pii: E1067. doi: 10.3390/molecules23051067. PubMed PMID: 29751500.

11: Dai Y, Ma F, Shen Y, Xie T, Gao S. Convergent Synthesis of Kibdelone C. Org Lett. 2018 May 18;20(10):2872-2875. doi: 10.1021/acs.orglett.8b00901. Epub 2018 May 8. PubMed PMID: 29738256.

12: Benatrehina PA, Pan L, Naman CB, Li J, Kinghorn AD. Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States. J Tradit Complement Med. 2018 Mar 2;8(2):267-277. doi: 10.1016/j.jtcme.2018.01.006. eCollection 2018 Apr. Review. PubMed PMID: 29736381; PubMed Central PMCID: PMC5934707.

13: Neves AR, Correia-da-Silva M, Silva PMA, Ribeiro D, Sousa E, Bousbaa H, Pinto M. Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth. Molecules. 2018 May 5;23(5). pii: E1093. doi: 10.3390/molecules23051093. PubMed PMID: 29734739.

14: Yang SQ, Li XM, Xu GM, Li X, An CY, Wang BG. Antibacterial anthraquinone derivatives isolated from a mangrove-derived endophytic fungus Aspergillus nidulans by ethanol stress strategy. J Antibiot (Tokyo). 2018 May 1. doi: 10.1038/s41429-018-0063-x. [Epub ahead of print] PubMed PMID: 29717199.

15: Rocha LW, Bonet IJM, Tambeli CH, de-Faria FM, Parada CA. Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1/epinephrine/PKA pathway and TNF-α inhibition. Eur J Pharmacol. 2018 Jul 5;830:87-94. doi: 10.1016/j.ejphar.2018.04.030. Epub 2018 Apr 30. PubMed PMID: 29715452.

16: Kubacka M, Szkaradek N, Mogilski S, Pańczyk K, Siwek A, Gryboś A, Filipek B, Żmudzki P, Marona H, Waszkielewicz AM. Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone. Bioorg Med Chem. 2018 Apr 18. pii: S0968-0896(17)32186-7. doi: 10.1016/j.bmc.2018.04.038. [Epub ahead of print] PubMed PMID: 29706529.

17: Koo YE, Song J, Bae S. Use of Plant and Herb Derived Medicine for Therapeutic Usage in Cardiology. Medicines (Basel). 2018 Apr 22;5(2). pii: E38. doi: 10.3390/medicines5020038. Review. PubMed PMID: 29690545.

18: Zhu L, Liu X, Li D, Sun S, Wang Y, Sun X. Autophagy is a pro-survival mechanism in ovarian cancer against the apoptotic effects of euxanthone. Biomed Pharmacother. 2018 Jul;103:708-718. doi: 10.1016/j.biopha.2018.04.090. Epub 2018 Apr 24. PubMed PMID: 29680739.

19: Khurana RK, Gaspar BL, Welsby G, Katare OP, Singh KK, Singh B. Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems. Drug Deliv Transl Res. 2018 Jun;8(3):617-632. doi: 10.1007/s13346-018-0498-4. PubMed PMID: 29637488; PubMed Central PMCID: PMC5937873.

20: Meepagala KM, Schrader KK. Antibacterial activity of constituents from mangosteen (Garcinia mangostana) fruit pericarp against several channel catfish pathogens. J Aquat Anim Health. 2018 Apr 10. doi: 10.1002/aah.10021. [Epub ahead of print] PubMed PMID: 29635710.