L524-0366

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MedKoo CAT#: 563033

CAS#: 951612-19-4

Description: L524-0366 is an inhibitor of the TWEAK-Fn14 signaling cascade.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-04-07. Prices are subject to change without notice.

L524-0366 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563033
Name: L524-0366
CAS#: 951612-19-4
Chemical Formula: C13H13ClN4OS
Exact Mass: 308.0499
Molecular Weight: 308.78
Elemental Analysis: C, 50.57; H, 4.24; Cl, 11.48; N, 18.14; O, 5.18; S, 10.38


Synonym: L524-0366; L524 0366; L5240366;

IUPAC/Chemical Name: [1-(3-Chloro-phenyl)-1H-[1,2,3]triazol-4-yl]-thiomorpholin-4-yl-methanone

InChi Key: ZOBDTKWDYMRKPF-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H13ClN4OS/c14-10-2-1-3-11(8-10)18-9-12(15-16-18)13(19)17-4-6-20-7-5-17/h1-3,8-9H,4-7H2

SMILES Code: O=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Xia Y, Campbell SR, Broder A, Herlitz L, Abadi M, Wu P, Michaelson JS, Burkly LC, Putterman C. Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis. Clin Immunol. 2012 Nov;145(2):108-21. doi: 10.1016/j.clim.2012.08.008. Epub 2012 Aug 20. PubMed PMID: 22982296; PubMed Central PMCID: PMC3483377.