Pantothenoylcysteine

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MedKoo CAT#: 596988

CAS#: 13147-34-7

Description: Pantothenoylcysteine is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-10. Prices are subject to change without notice.

Pantothenoylcysteine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596988
Name: Pantothenoylcysteine
CAS#: 13147-34-7
Chemical Formula: C12H22N2O6S
Exact Mass: 322.1199
Molecular Weight: 322.37
Elemental Analysis: C, 44.71; H, 6.88; N, 8.69; O, 29.78; S, 9.94


Synonym: Pantothenoylcysteine;

IUPAC/Chemical Name: (3-((R)-2,4-dihydroxy-3,3-dimethylbutanamido)propanoyl)-L-cysteine

InChi Key: QSYCTARXWYLMOF-CBAPKCEASA-N

InChi Code: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/t7-,9-/m0/s1

SMILES Code: SC[C@@H](C(O)=O)NC(CCNC([C@H](O)C(C)(C)CO)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kupke T. Active-site residues and amino acid specificity of the bacterial 4'-phosphopantothenoylcysteine synthetase CoaB. Eur J Biochem. 2004 Jan;271(1):163-72. PubMed PMID: 14686929.

2: Hernández-Acosta P, Schmid DG, Jung G, Culiáñez-Macià FA, Kupke T. Molecular characterization of the Arabidopsis thaliana flavoprotein AtHAL3a reveals the general reaction mechanism of 4'-phosphopantothenoylcysteine decarboxylases. J Biol Chem. 2002 Jun 7;277(23):20490-8. Epub 2002 Mar 28. PubMed PMID: 11923307.

3: Kupke T. Molecular characterization of the 4'-phosphopantothenoylcysteine decarboxylase domain of bacterial Dfp flavoproteins. J Biol Chem. 2001 Jul 20;276(29):27597-604. Epub 2001 May 17. PubMed PMID: 11358972.

4: Kupke T, Hernandez-Acosta P, Steinbacher S, Culianez-Macia FA. Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-Phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis. J Biol Chem. 2001 Jun 1;276(22):19190-6. Epub 2001 Mar 2. PubMed PMID: 11279129.

5: Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP. Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. J Biol Chem. 2001 Apr 27;276(17):13513-6. Epub 2001 Mar 13. PubMed PMID: 11278255.

6: Kupke T, Uebele M, Schmid D, Jung G, Blaesse M, Steinbacher S. Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. J Biol Chem. 2000 Oct 13;275(41):31838-46. PubMed PMID: 10922366.

7: Scandurra R, Barboni E, Granata F, Pensa B, Costa M. Pantothenoylcysteine-4' -phosphate decarboxylase from horse liver. Eur J Biochem. 1974 Nov 1;49(1):1-9. PubMed PMID: 4459135.

8: Scandurra R, Marcucci M, Federici G. Formation of thiazoline ring in pantothenoylcysteine 4'-phosphate. Acta Vitaminol Enzymol. 1970;24(4):118-22. PubMed PMID: 5537189.