Pantothenoylcysteine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596988

CAS#: 13147-34-7

Description: Pantothenoylcysteine is a bioactive chemical.

Chemical Structure

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Pantothenoylcysteine
CAS# 13147-34-7
Instruction

Theoretical Analysis

MedKoo Cat#: 596988
Name: Pantothenoylcysteine
CAS#: 13147-34-7
Chemical Formula: C12H22N2O6S
Exact Mass: 322.12
Molecular Weight: 322.370
Elemental Analysis: C, 44.71; H, 6.88; N, 8.69; O, 29.78; S, 9.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Pantothenoylcysteine;

IUPAC/Chemical Name: (3-((R)-2,4-dihydroxy-3,3-dimethylbutanamido)propanoyl)-L-cysteine

InChi Key: QSYCTARXWYLMOF-CBAPKCEASA-N

InChi Code: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/t7-,9-/m0/s1

SMILES Code: SC[C@@H](C(O)=O)NC(CCNC([C@H](O)C(C)(C)CO)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 322.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Kupke T. Active-site residues and amino acid specificity of the bacterial 4'-phosphopantothenoylcysteine synthetase CoaB. Eur J Biochem. 2004 Jan;271(1):163-72. PubMed PMID: 14686929.

2: Hernández-Acosta P, Schmid DG, Jung G, Culiáñez-Macià FA, Kupke T. Molecular characterization of the Arabidopsis thaliana flavoprotein AtHAL3a reveals the general reaction mechanism of 4'-phosphopantothenoylcysteine decarboxylases. J Biol Chem. 2002 Jun 7;277(23):20490-8. Epub 2002 Mar 28. PubMed PMID: 11923307.

3: Kupke T. Molecular characterization of the 4'-phosphopantothenoylcysteine decarboxylase domain of bacterial Dfp flavoproteins. J Biol Chem. 2001 Jul 20;276(29):27597-604. Epub 2001 May 17. PubMed PMID: 11358972.

4: Kupke T, Hernandez-Acosta P, Steinbacher S, Culianez-Macia FA. Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-Phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis. J Biol Chem. 2001 Jun 1;276(22):19190-6. Epub 2001 Mar 2. PubMed PMID: 11279129.

5: Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP. Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. J Biol Chem. 2001 Apr 27;276(17):13513-6. Epub 2001 Mar 13. PubMed PMID: 11278255.

6: Kupke T, Uebele M, Schmid D, Jung G, Blaesse M, Steinbacher S. Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. J Biol Chem. 2000 Oct 13;275(41):31838-46. PubMed PMID: 10922366.

7: Scandurra R, Barboni E, Granata F, Pensa B, Costa M. Pantothenoylcysteine-4' -phosphate decarboxylase from horse liver. Eur J Biochem. 1974 Nov 1;49(1):1-9. PubMed PMID: 4459135.

8: Scandurra R, Marcucci M, Federici G. Formation of thiazoline ring in pantothenoylcysteine 4'-phosphate. Acta Vitaminol Enzymol. 1970;24(4):118-22. PubMed PMID: 5537189.