L-Chlorozotocin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596960

CAS#: 69839-80-1

Description: L-Chlorozotocin is a glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas.

Chemical Structure

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L-Chlorozotocin
CAS# 69839-80-1
Instruction

Theoretical Analysis

MedKoo Cat#: 596960
Name: L-Chlorozotocin
CAS#: 69839-80-1
Chemical Formula: C9H16ClN3O7
Exact Mass: 313.07
Molecular Weight: 313.690
Elemental Analysis: C, 34.46; H, 5.14; Cl, 11.30; N, 13.40; O, 35.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L-Chlorozotocin; NSC 291322; NSC-291322; NSC291322;

IUPAC/Chemical Name: 1-(2-chloroethyl)-1-nitroso-3-((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)urea

InChi Key: MKQWTWSXVILIKJ-LXGUWJNJSA-N

InChi Code: InChI=1S/C9H16ClN3O7/c10-1-2-13(12-20)9(19)11-5(3-14)7(17)8(18)6(16)4-15/h3,5-8,15-18H,1-2,4H2,(H,11,19)/t5-,6+,7+,8+/m0/s1

SMILES Code: O=C[C@H](NC(N(CCCl)N=O)=O)[C@H]([C@@H]([C@@H](CO)O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 313.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Johnston TP, McCaleb GS, Anderson T, Murinson DS. L-Chlorozotocin. J Med Chem. 1979 May;22(5):597-9. PubMed PMID: 156793.