L-Carnitine tartrate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596950

CAS#: 36687-82-8

Description: L-Carnitine tartrate is a Carnitine/ Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.

Chemical Structure

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L-Carnitine tartrate
CAS# 36687-82-8
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 596950
Name: L-Carnitine tartrate
CAS#: 36687-82-8
Chemical Formula: C18H36N2O12
Exact Mass: 0.00
Molecular Weight: 472.490
Elemental Analysis: C, 45.76; H, 7.68; N, 5.93; O, 40.63

Price and Availability

Size Price Availability Quantity
25g USD 250 2 Weeks
100g USD 550 2 Weeks
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Synonym: L-Carnitine tartrate; L-Carnitine L-tartrate; Carnipure tartrate;

IUPAC/Chemical Name: (R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium (2R,3R)-2,3-dihydroxysuccinate

InChi Key: GADIJPCDIWZEMB-BTNVMJJCSA-N

InChi Code: InChI=1S/2C7H15NO3.C4H6O6/c2*1-8(2,3)5-6(9)4-7(10)11;5-1(3(7)8)2(6)4(9)10/h2*6,9H,4-5H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t2*6-;1-,2-/m111/s1

SMILES Code: C[N+](C)(C)C[C@H](O)CC(O)=O.C[N+](C)(C)C[C@H](O)CC(O)=O.O=C([O-])[C@H](O)[C@@H](O)C([O-])=O

Appearance: Solid powder

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: L-Carnitine tartrate is a Carnitine/ Constituent of striated muscle and liver.
In vitro activity: In the following, cells were treated with LC (L-Carnitine) and at the end of the treatment period, the cells were subjected to the real-time PCR technique along with western blotting assay for measurement of the telomere length and assessment of protein expression, respectively. The results showed that 0.2 mM LC caused the elongation of the telomere length and increased the TERT protein expression. Reference: Curr Stem Cell Res Ther. 2022 May 11. https://pubmed.ncbi.nlm.nih.gov/35546751/
In vivo activity: The present study investigated how L-carnitine affected the acoustic startle response (ASR) in rats exposed to mancozeb. The results showed that locomotor activity and the percentage of prepulse inhibition in the mancozeb groups decreased compared to the sham group while these parameters increased in the L-carnitine group (200 mg/kg) compared to sham rats. Reference: Toxicol Ind Health. 2023 Jan 17:7482337231151739. https://pubmed.ncbi.nlm.nih.gov/36650049/

Preparing Stock Solutions

The following data is based on the product molecular weight 472.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Fathi E, Montazersaheb S, Sanaat Z, Nakhlband A, Vandghanooni S, Farahzadi R, Vietor I. L-carnitine reduced cellular aging of bone marrow resident C-kit+ hematopoietic stem cells through telomere dependent pathways. Curr Stem Cell Res Ther. 2022 May 11. doi: 10.2174/1574888X17666220511141123. Epub ahead of print. PMID: 35546751. 2. Lee YG, Chou HC, Chen YT, Tung SY, Ko TL, Buyandelger B, Wen LL, Juan SH. L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci Rep. 2022 Mar 18;12(1):4673. doi: 10.1038/s41598-022-08771-3. PMID: 35304586; PMCID: PMC8933466. 3. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Jan 17:7482337231151739. doi: 10.1177/07482337231151739. Epub ahead of print. PMID: 36650049. 4. Chang D, Kong F, Jiang W, Li F, Zhang C, Ding H, Kang Y, Li W, Huang C, Zhou X, Zhang X, Jiao H, Kang Y, Shang X, Zhang B. Effects of L-carnitine Administration on Sperm and Sex Hormone Levels in a Male Wistar Rat Reproductive System Injury Model in a High-Altitude Hypobaric Hypoxic Environment. Reprod Sci. 2023 Jan 12. doi: 10.1007/s43032-022-00948-5. Epub ahead of print. PMID: 36633830.
In vitro protocol: 1. Fathi E, Montazersaheb S, Sanaat Z, Nakhlband A, Vandghanooni S, Farahzadi R, Vietor I. L-carnitine reduced cellular aging of bone marrow resident C-kit+ hematopoietic stem cells through telomere dependent pathways. Curr Stem Cell Res Ther. 2022 May 11. doi: 10.2174/1574888X17666220511141123. Epub ahead of print. PMID: 35546751. 2. Lee YG, Chou HC, Chen YT, Tung SY, Ko TL, Buyandelger B, Wen LL, Juan SH. L-Carnitine reduces reactive oxygen species/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci Rep. 2022 Mar 18;12(1):4673. doi: 10.1038/s41598-022-08771-3. PMID: 35304586; PMCID: PMC8933466.
In vivo protocol: 1. Dehghani A, Pourjafari F, Koohkan F, Haghpanh T, Pourjafari F, Sheibani V, Afarinesh MR. L-carnitine attenuates acoustic startle reflex dysfunction in adult male rats exposed to mancozeb. Toxicol Ind Health. 2023 Jan 17:7482337231151739. doi: 10.1177/07482337231151739. Epub ahead of print. PMID: 36650049. 2. Chang D, Kong F, Jiang W, Li F, Zhang C, Ding H, Kang Y, Li W, Huang C, Zhou X, Zhang X, Jiao H, Kang Y, Shang X, Zhang B. Effects of L-carnitine Administration on Sperm and Sex Hormone Levels in a Male Wistar Rat Reproductive System Injury Model in a High-Altitude Hypobaric Hypoxic Environment. Reprod Sci. 2023 Jan 12. doi: 10.1007/s43032-022-00948-5. Epub ahead of print. PMID: 36633830.

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1: Sawicka AK, Hartmane D, Lipinska P, Wojtowicz E, Lysiak-Szydlowska W, Olek RA. l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function. Nutrients. 2018 Feb 23;10(2). pii: E255. doi: 10.3390/nu10020255. PubMed PMID: 29473908; PubMed Central PMCID: PMC5852831.

2: Badawi AA, Hegazy MM, Louis D, Eldegwy MA. Solving manufacturing problems for L-carnitine-L-tartrate to improve the likelihood of successful product scale-up. Acta Pharm. 2017 Dec 20;67(4):511-525. doi: 10.1515/acph-2017-0033. PubMed PMID: 29337668.

3: Kleinguetl C, Williams JC Jr, Ibrahim SA, Daudon M, Bird ET, El Tayeb MM. Calcium Tartrate Tetrahydrate, Case Report of a Novel Human Kidney Stone. J Endourol Case Rep. 2017 Dec 1;3(1):192-195. doi: 10.1089/cren.2017.0118. eCollection 2017. PubMed PMID: 29279874; PubMed Central PMCID: PMC5734156.

4: Mohammadi H, Djalali M, Daneshpazhooh M, Honarvar NM, Chams-Davatchi C, Sepandar F, Fakhri Z, Yaghubi E, Zarei M, Javanbakht MH. Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2017 Aug 23. doi: 10.1038/ejcn.2017.131. [Epub ahead of print] PubMed PMID: 28832573.

5: Shannon CE, Nixon AV, Greenhaff PL, Stephens FB. Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men. Am J Clin Nutr. 2016 Jan;103(1):276-82. doi: 10.3945/ajcn.115.119826. Epub 2015 Dec 16. PubMed PMID: 26675771; PubMed Central PMCID: PMC4756606.

6: Qadir MA, Ahmed M, Hussain WA, Tahir MS. Development and Validation of New HPLC Method for Simultaneous Estimation of L-Lysine Hydrochloride and L-Carnitine-L-Tartrate in Pharmaceutical Dosage Form. Indian J Pharm Sci. 2015 Jul-Aug;77(4):434-8. PubMed PMID: 26664059; PubMed Central PMCID: PMC4649793.

7: Naclerio F, Larumbe-Zabala E, Cooper R, Allgrove J, Earnest CP. A multi-ingredient containing carbohydrate, proteins L-glutamine and L-carnitine attenuates fatigue perception with no effect on performance, muscle damage or immunity in soccer players. PLoS One. 2015 Apr 27;10(4):e0125188. doi: 10.1371/journal.pone.0125188. eCollection 2015. PubMed PMID: 25915424; PubMed Central PMCID: PMC4411100.

8: Naclerio F, Larumbe-Zabala E, Cooper R, Jimenez A, Goss-Sampson M. Effect of a carbohydrate-protein multi-ingredient supplement on intermittent sprint performance and muscle damage in recreational athletes. Appl Physiol Nutr Metab. 2014 Oct;39(10):1151-8. doi: 10.1139/apnm-2013-0556. Epub 2014 May 5. PubMed PMID: 25029675.

9: Outlaw J, Wilborn C, Smith A, Urbina S, Hayward S, Foster C, Wells S, Wildman R, Taylor L. Effects of ingestion of a commercially available thermogenic dietary supplement on resting energy expenditure, mood state and cardiovascular measures. J Int Soc Sports Nutr. 2013 Apr 30;10(1):25. doi: 10.1186/1550-2783-10-25. PubMed PMID: 23627832; PubMed Central PMCID: PMC3651299.

10: Fox LT, Gerber M, du Preez JL, Grobler A, du Plessis J. Topical and transdermal delivery of L-carnitine. Skin Pharmacol Physiol. 2011;24(6):330-6. doi: 10.1159/000330385. Epub 2011 Aug 11. PubMed PMID: 21832865.

11: Broad EM, Maughan RJ, Galloway S DR. Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. Int J Sport Nutr Exerc Metab. 2011 Oct;21(5):385-97. Epub 2011 Aug 3. PubMed PMID: 21813919.

12: Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol. 2011 Feb 15;589(Pt 4):963-73. doi: 10.1113/jphysiol.2010.201343. Epub 2011 Jan 4. PubMed PMID: 21224234; PubMed Central PMCID: PMC3060373.

13: Galloway SD, Craig TP, Cleland SJ. Effects of oral L-carnitine supplementation on insulin sensitivity indices in response to glucose feeding in lean and overweight/obese males. Amino Acids. 2011 Jul;41(2):507-15. doi: 10.1007/s00726-010-0770-5. Epub 2010 Oct 21. PubMed PMID: 20963457.

14: Ho JY, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, Coday M, Häkkinen K, Maresh CM. l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism. 2010 Aug;59(8):1190-9. doi: 10.1016/j.metabol.2009.11.012. Epub 2009 Dec 31. PubMed PMID: 20045157.

15: Keller U, van der Wal C, Seliger G, Scheler C, Röpke F, Eder K. Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration. Eur J Clin Nutr. 2009 Sep;63(9):1098-105. doi: 10.1038/ejcn.2009.36. Epub 2009 Jun 3. PubMed PMID: 19491916.

16: Broad EM, Maughan RJ, Galloway SD. Carbohydrate, protein, and fat metabolism during exercise after oral carnitine supplementation in humans. Int J Sport Nutr Exerc Metab. 2008 Dec;18(6):567-84. PubMed PMID: 19164828.

17: Volek JS, Judelson DA, Silvestre R, Yamamoto LM, Spiering BA, Hatfield DL, Vingren JL, Quann EE, Anderson JM, Maresh CM, Kraemer WJ. Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. Am J Cardiol. 2008 Nov 15;102(10):1413-7. doi: 10.1016/j.amjcard.2008.07.022. Epub 2008 Sep 11. PubMed PMID: 18993165.

18: Spiering BA, Kraemer WJ, Hatfield DL, Vingren JL, Fragala MS, Ho JY, Thomas GA, Häkkinen K, Volek JS. Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise. J Strength Cond Res. 2008 Jul;22(4):1130-5. doi: 10.1519/JSC.0b013e31817d48d9. PubMed PMID: 18545197.

19: Hooshmand S, Balakrishnan A, Clark RM, Owen KQ, Koo SI, Arjmandi BH. Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Phytomedicine. 2008 Aug;15(8):595-601. doi: 10.1016/j.phymed.2008.02.026. Epub 2008 Jun 9. PubMed PMID: 18539446.

20: Foitzik K, Hoting E, Förster T, Pertile P, Paus R. L-carnitine-L-tartrate promotes human hair growth in vitro. Exp Dermatol. 2007 Nov;16(11):936-45. PubMed PMID: 17927577.