Terbumeton
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MedKoo CAT#: 558091

CAS#: 33693-04-8

Description: Terbumeton is an herbicide.

Chemical Structure

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Terbumeton
CAS# 33693-04-8
Instruction

Theoretical Analysis

MedKoo Cat#: 558091
Name: Terbumeton
CAS#: 33693-04-8
Chemical Formula: C10H19N5O
Exact Mass: 225.16
Molecular Weight: 225.300
Elemental Analysis: C, 53.31; H, 8.50; N, 31.09; O, 7.10

Price and Availability

Size Price Availability Quantity
250mg USD 230
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Synonym: GS 14259; Karagard; Caragard; Terbumeton; Terbuthylon;

IUPAC/Chemical Name: 1,3,5-Triazine-2,4-diamine, N-(1,1-dimethylethyl)-N'-ethyl-6-methoxy-

InChi Key: BCQMBFHBDZVHKU-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H19N5O/c1-6-11-7-12-8(15-10(2,3)4)14-9(13-7)16-5/h6H2,1-5H3,(H2,11,12,13,14,15)

SMILES Code: COC1=NC(NC(C)(C)C)=NC(NCC)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 225.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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8: Mandarapu R, Prakhya BM. In vitro myelotoxic effects of cypermethrin and mancozeb on human hematopoietic progenitor cells. J Immunotoxicol. 2015 Jan-Mar;12(1):48-55. doi: 10.3109/1547691X.2014.880535. Epub 2014 Feb 5. PubMed PMID: 24499300.

9: Hoffman L, Trombetta L, Hardej D. Ethylene bisdithiocarbamate pesticides Maneb and Mancozeb cause metal overload in human colon cells. Environ Toxicol Pharmacol. 2016 Jan;41:78-88. doi: 10.1016/j.etap.2015.11.002. Epub 2015 Nov 7. PubMed PMID: 26650801.

10: Yahia E, Aiche MA, Chouabbia A, Boulakoud MS. SUBCHRONIC MANCOZEB TREATEMENT INDUCED LIVER TOXICITY VIA OXIDATIVE STRESS IN MALE WISTAR RATS. Commun Agric Appl Biol Sci. 2014;79(3):553-9. PubMed PMID: 26080489.

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12: Iorio R, Castellucci A, Rossi G, Cinque B, Cifone MG, Macchiarelli G, Cecconi S. Mancozeb affects mitochondrial activity, redox status and ATP production in mouse granulosa cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):438-45. doi: 10.1016/j.tiv.2015.09.018. Epub 2015 Sep 25. PubMed PMID: 26407525.

13: Atamaniuk TM, Kubrak OI, Husak VV, Storey KB, Lushchak VI. The Mancozeb-containing carbamate fungicide tattoo induces mild oxidative stress in goldfish brain, liver, and kidney. Environ Toxicol. 2014 Nov;29(11):1227-35. doi: 10.1002/tox.21853. Epub 2013 Feb 23. PubMed PMID: 23436297.

14: van Wendel de Joode B, Barbeau B, Bouchard MF, Mora AM, Skytt Å, Córdoba L, Quesada R, Lundh T, Lindh CH, Mergler D. Manganese concentrations in drinking water from villages near banana plantations with aerial mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA). Environ Pollut. 2016 Aug;215:247-257. doi: 10.1016/j.envpol.2016.04.015. Epub 2016 May 19. PubMed PMID: 27208757.

15: Pandey SP, Mohanty B. The neonicotinoid pesticide imidacloprid and the dithiocarbamate fungicide mancozeb disrupt the pituitary-thyroid axis of a wildlife bird. Chemosphere. 2015 Mar;122:227-234. doi: 10.1016/j.chemosphere.2014.11.061. Epub 2014 Dec 12. PubMed PMID: 25496744.

16: Mirković B, Tanović B, Stević M, Hrustić J, Mihajlović M, Delibašić G, Vukša P. Toxicity of mancozeb, chlorothalonil, captan, fluopyram, boscalid, and difenoconazole to Didymella applanata isolates from Serbia. J Environ Sci Health B. 2015;50(12):845-50. doi: 10.1080/03601234.2015.1062648. Epub 2015 Aug 7. PubMed PMID: 26252498.

17: Harrison Brody A, Chou E, Gray JM, Pokyrwka NJ, Raley-Susman KM. Mancozeb-induced behavioral deficits precede structural neural degeneration. Neurotoxicology. 2013 Jan;34:74-81. doi: 10.1016/j.neuro.2012.10.007. Epub 2012 Oct 24. PubMed PMID: 23103283.

18: Cheng SY, Oh S, Velasco M, Ta C, Montalvo J, Calderone A. RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB. J Biochem Mol Toxicol. 2014 Jul;28(7):302-11. doi: 10.1002/jbt.21566. Epub 2014 Apr 25. PubMed PMID: 24764117.

19: Pirozzi AV, Stellavato A, La Gatta A, Lamberti M, Schiraldi C. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicol Lett. 2016 May 13;249:1-4. doi: 10.1016/j.toxlet.2016.03.004. Epub 2016 Mar 22. PubMed PMID: 27016407.

20: van Wendel de Joode B, Mora AM, Córdoba L, Cano JC, Quesada R, Faniband M, Wesseling C, Ruepert C, Oberg M, Eskenazi B, Mergler D, Lindh CH. Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA). Environ Health Perspect. 2014 Dec;122(12):1321-8. doi: 10.1289/ehp.1307679. Epub 2014 Sep 8. Erratum in: Environ Health Perspect. 2014 Dec;122(12):A321. PubMed PMID: 25198283; PubMed Central PMCID: PMC4256696.