WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562974
Description: JNJ-28610244 is a specific H4 receptor agonist that acts by blocking Mac-1-dependent activation of p38 MAPK.
MedKoo Cat#: 562974
Chemical Formula: C16H21N3O
Exact Mass: 271.1685
Molecular Weight: 271.36
Elemental Analysis: C, 70.82; H, 7.80; N, 15.49; O, 5.90
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: JNJ-28610244; JNJ 28610244; JNJ28610244;
IUPAC/Chemical Name: (Z)-(5-Methyl-1H-indol-2-yl)-(1-methyl-piperidin-4-yl)-methanone oxime
InChi Key: VOIJIMTXMUBFDD-VLGSPTGOSA-N
InChi Code: InChI=1S/C16H21N3O/c1-11-3-4-14-13(9-11)10-15(17-14)16(18-20)12-5-7-19(2)8-6-12/h3-4,9-10,12,17,20H,5-8H2,1-2H3/b18-16-
SMILES Code: CN1CCC(/C(C(N2)=CC3=C2C=CC(C)=C3)=N/O)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 271.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dib K, Perecko T, Jenei V, McFarlane C, Comer D, Brown V, Katebe M, Scheithauer T, Thurmond RL, Chazot PL, Ennis M. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. J Leukoc Biol. 2014 Sep;96(3):411-8. doi: 10.1189/jlb.2AB0813-432RR. Epub 2014 May 5. PubMed PMID: 24799603; PubMed Central PMCID: PMC5395935.
2: Desai P, Thurmond RL. Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. Eur J Immunol. 2011 Jun;41(6):1764-73. doi: 10.1002/eji.201040932. Epub 2011 May 25. PubMed PMID: 21469095.