WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596796

CAS#: 444169-80-6

Description: ICAM-1988 is an LFA-1 antagonist.

Chemical Structure

CAS# 444169-80-6

Theoretical Analysis

MedKoo Cat#: 596796
Name: ICAM-1988
CAS#: 444169-80-6
Chemical Formula: C22H22Cl2N4O6S
Exact Mass: 540.0637
Molecular Weight: 541.4
Elemental Analysis: C, 48.81; H, 4.10; Cl, 13.10; N, 10.35; O, 17.73; S, 5.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICAM-1988; ICAM 1988; ICAM1988;

IUPAC/Chemical Name: (S)-2-(2,6-dichloro-4-(((E)-3-(furan-2-yl)acrylamido)methyl)benzamido)-3-((R)-thiazolidine-4-carboxamido)propanoic acid


InChi Code: InChI=1S/C22H22Cl2N4O6S/c23-14-6-12(8-25-18(29)4-3-13-2-1-5-34-13)7-15(24)19(14)21(31)28-16(22(32)33)9-26-20(30)17-10-35-11-27-17/h1-7,16-17,27H,8-11H2,(H,25,29)(H,26,30)(H,28,31)(H,32,33)/b4-3+/t16-,17-/m0/s1

SMILES Code: O=C(O)[C@H](CNC([C@H]1NCSC1)=O)NC(C2=C(Cl)C=C(CNC(/C=C/C3=CC=CO3)=O)C=C2Cl)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 541.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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5: Mendez MP, Monroy YK, Du M, Preston AM, Tolle L, Lin Y, VanDussen KL, Samuelson LC, Standiford TJ, Curtis JL, Beck JM, Christensen PJ, Paine R 3rd. Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia. Respir Res. 2011 Jan 19;12:12. doi: 10.1186/1465-9921-12-12. PubMed PMID: 21247482; PubMed Central PMCID: PMC3034680.

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7: Khojasteh SC, Leipold DD, Lai F, La H, Baumgardner MJ, Desino KE, Gudmundsson OS, Bloedow DC, Bodary SC, Reynolds ME, Gadek TR, Kenkare-Mitra S. Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug. Xenobiotica. 2008 Mar;38(3):340-52. doi: 10.1080/00498250701813248 . PubMed PMID: 18274961.