D-Alanyl-L-alanine
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MedKoo CAT#: 596770

CAS#: 1115-78-2

Description: D-Alanyl-L-alanine is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
1g USD 540 2 Weeks
5g USD 1270 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

D-Alanyl-L-alanine purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596770
Name: D-Alanyl-L-alanine
CAS#: 1115-78-2
Chemical Formula: C6H12N2O3
Exact Mass: 160.0848
Molecular Weight: 160.17
Elemental Analysis: C, 44.99; H, 7.55; N, 17.49; O, 29.97


Synonym: D-Alanyl-L-alanine; D-Alanylalanine; N-D-Alanyl-L-alanine; L-Alanine, D-alanyl-; NSC-203792; NSC 203792; NSC203792;

IUPAC/Chemical Name: D-alanyl-L-alanine

InChi Key: DEFJQIDDEAULHB-DMTCNVIQSA-N

InChi Code: InChI=1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1

SMILES Code: C[C@H](C(N[C@H](C(O)=O)C)=O)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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2: Stelzl LS, Hummer G. Kinetics from Replica Exchange Molecular Dynamics Simulations. J Chem Theory Comput. 2017 Aug 8;13(8):3927-3935. doi: 10.1021/acs.jctc.7b00372. Epub 2017 Jul 21. PubMed PMID: 28657736.

3: Peter EK, Shea JE. An adaptive bias - hybrid MD/kMC algorithm for protein folding and aggregation. Phys Chem Chem Phys. 2017 Jul 5;19(26):17373-17382. doi: 10.1039/c7cp03035e. PubMed PMID: 28650060.

4: Nascimento TP, Sales AE, Porto TS, Costa RMPB, Breydo L, Uversky VN, Porto ALF, Converti A. Purification, biochemical, and structural characterization of a novel fibrinolytic enzyme from Mucor subtilissimus UCP 1262. Bioprocess Biosyst Eng. 2017 Aug;40(8):1209-1219. doi: 10.1007/s00449-017-1781-3. Epub 2017 May 12. PubMed PMID: 28500420.

5: Lanza G, Chiacchio MA. Quantum Mechanics Approach to Hydration Energies and Structures of Alanine and Dialanine. Chemphyschem. 2017 Jun 20;18(12):1586-1596. doi: 10.1002/cphc.201700149. Epub 2017 Apr 26. PubMed PMID: 28371186.

6: Kim SJ, Singh M, Sharif S, Schaefer J. Desleucyl-Oritavancin with a Damaged d-Ala-d-Ala Binding Site Inhibits the Transpeptidation Step of Cell-Wall Biosynthesis in Whole Cells of Staphylococcus aureus. Biochemistry. 2017 Mar 14;56(10):1529-1535. doi: 10.1021/acs.biochem.6b01125. Epub 2017 Mar 3. PubMed PMID: 28221772; PubMed Central PMCID: PMC5508972.

7: Xie L, Shen L, Chen ZN, Yang M. Efficient free energy calculations by combining two complementary tempering sampling methods. J Chem Phys. 2017 Jan 14;146(2):024103. doi: 10.1063/1.4973607. PubMed PMID: 28088161.

8: Ihara K, Sato K, Hori H, Makino Y, Shigenobu S, Ando T, Isogai E, Yoneyama H. Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli. J Biosci Bioeng. 2017 Apr;123(4):444-450. doi: 10.1016/j.jbiosc.2016.11.015. Epub 2017 Jan 3. PubMed PMID: 28057466.

9: Chang JD, Foster EE, Yang H, Kim SJ. Quantification of the d-Ala-d-Lac-Terminated Peptidoglycan Structure in Vancomycin-Resistant Enterococcus faecalis Using a Combined Solid-State Nuclear Magnetic Resonance and Mass Spectrometry Analysis. Biochemistry. 2017 Jan 31;56(4):612-622. doi: 10.1021/acs.biochem.6b00774. Epub 2017 Jan 17. PubMed PMID: 28040891.

10: Lee SJ, Jang JH, Yoon GY, Kang DR, Park HJ, Shin SJ, Han HD, Kang TH, Park WS, Yoon YK, Soh BY, Jung ID, Park YM. Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity. BMB Rep. 2016 Oct;49(10):554-559. PubMed PMID: 27439605; PubMed Central PMCID: PMC5227297.

11: Xing M, Simmonds RS, Timkovich R. Solution structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain of Zoocin A. Proteins. 2017 Jan;85(1):177-181. doi: 10.1002/prot.25178. Epub 2016 Oct 24. PubMed PMID: 27699884.

12: Miki Y, Okazaki S, Asano Y. Engineering an ATP-dependent D-Ala:D-Ala ligase for synthesizing amino acid amides from amino acids. J Ind Microbiol Biotechnol. 2017 May;44(4-5):667-675. doi: 10.1007/s10295-016-1833-8. Epub 2016 Sep 1. PubMed PMID: 27585794.

13: Wang Y, Wang J, Zhao H, Zhang J, Zhang T, Zeng J, Zhou W, Zhang C. Assessment of enzyme measurement procedures in China through a trueness verification program. Clin Chim Acta. 2016 Oct 1;461:98-102. doi: 10.1016/j.cca.2016.07.008. Epub 2016 Jul 15. PubMed PMID: 27425848.

14: Qiao Q, Zhang HD, Huang X. Enhancing pairwise state-transition weights: A new weighting scheme in simulated tempering that can minimize transition time between a pair of conformational states. J Chem Phys. 2016 Apr 21;144(15):154107. doi: 10.1063/1.4946793. PubMed PMID: 27389209.

15: Munegumi T. Epimerization of Alanyl-Alanine Induced by γ-Rays Irradiation in Aqueous Solutions. Orig Life Evol Biosph. 2017 Mar;47(1):69-82. doi: 10.1007/s11084-016-9507-0. Epub 2016 May 31. PubMed PMID: 27245350.

16: Katsube S, Sato K, Ando T, Isogai E, Yoneyama H. Secretion of d-alanine by Escherichia coli. Microbiology. 2016 Jul;162(7):1243-52. doi: 10.1099/mic.0.000305. Epub 2016 May 6. PubMed PMID: 27166225.

17: Li W, Ma A. Reaction mechanism and reaction coordinates from the viewpoint of energy flow. J Chem Phys. 2016 Mar 21;144(11):114103. doi: 10.1063/1.4943581. PubMed PMID: 27004858; PubMed Central PMCID: PMC4798989.

18: Zheng W, de Sancho D, Best RB. Modulation of Folding Internal Friction by Local and Global Barrier Heights. J Phys Chem Lett. 2016 Mar 17;7(6):1028-34. doi: 10.1021/acs.jpclett.6b00329. Epub 2016 Mar 7. PubMed PMID: 26947615; PubMed Central PMCID: PMC5578457.

19: Hamada Y. A novel N-terminal degradation reaction of peptides via N-amidination. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1690-5. doi: 10.1016/j.bmcl.2016.02.058. Epub 2016 Feb 21. PubMed PMID: 26916439.

20: Almeida GG, Cordeiro JM, Martín ME, Aguilar MA. Conformational Changes of the Alanine Dipeptide in Water-Ethanol Binary Mixtures. J Chem Theory Comput. 2016 Apr 12;12(4):1514-24. doi: 10.1021/acs.jctc.5b00952. Epub 2016 Mar 4. PubMed PMID: 26910305.