D-Alanyl-L-alanine | CAS#1115-78-2 | bioactive chemical

D-Alanyl-L-alanine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596770

CAS#: 1115-78-2

Description: D-Alanyl-L-alanine is a bioactive chemical.

Chemical Structure

D-Alanyl-L-alanine

CAS# 1115-78-2

Instruction

Theoretical Analysis

MedKoo Cat#: 596770
Name: D-Alanyl-L-alanine
CAS#: 1115-78-2
Chemical Formula: C6H12N2O3
Exact Mass: 160.08
Molecular Weight: 160.170
Elemental Analysis: C, 44.99; H, 7.55; N, 17.49; O, 29.97

Price and Availability

Size	Price	Availability	Quantity
1g	USD 540
5g	USD 1270
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: D-Alanyl-L-alanine; D-Alanylalanine; N-D-Alanyl-L-alanine; L-Alanine, D-alanyl-; NSC-203792; NSC 203792; NSC203792;

IUPAC/Chemical Name: D-alanyl-L-alanine

InChi Key: DEFJQIDDEAULHB-DMTCNVIQSA-N

InChi Code: InChI=1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1

SMILES Code: C[C@H](C(N[C@H](C(O)=O)C)=O)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 160.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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6: Kim SJ, Singh M, Sharif S, Schaefer J. Desleucyl-Oritavancin with a Damaged d-Ala-d-Ala Binding Site Inhibits the Transpeptidation Step of Cell-Wall Biosynthesis in Whole Cells of Staphylococcus aureus. Biochemistry. 2017 Mar 14;56(10):1529-1535. doi: 10.1021/acs.biochem.6b01125. Epub 2017 Mar 3. PubMed PMID: 28221772; PubMed Central PMCID: PMC5508972.

7: Xie L, Shen L, Chen ZN, Yang M. Efficient free energy calculations by combining two complementary tempering sampling methods. J Chem Phys. 2017 Jan 14;146(2):024103. doi: 10.1063/1.4973607. PubMed PMID: 28088161.

8: Ihara K, Sato K, Hori H, Makino Y, Shigenobu S, Ando T, Isogai E, Yoneyama H. Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli. J Biosci Bioeng. 2017 Apr;123(4):444-450. doi: 10.1016/j.jbiosc.2016.11.015. Epub 2017 Jan 3. PubMed PMID: 28057466.

9: Chang JD, Foster EE, Yang H, Kim SJ. Quantification of the d-Ala-d-Lac-Terminated Peptidoglycan Structure in Vancomycin-Resistant Enterococcus faecalis Using a Combined Solid-State Nuclear Magnetic Resonance and Mass Spectrometry Analysis. Biochemistry. 2017 Jan 31;56(4):612-622. doi: 10.1021/acs.biochem.6b00774. Epub 2017 Jan 17. PubMed PMID: 28040891.

10: Lee SJ, Jang JH, Yoon GY, Kang DR, Park HJ, Shin SJ, Han HD, Kang TH, Park WS, Yoon YK, Soh BY, Jung ID, Park YM. Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity. BMB Rep. 2016 Oct;49(10):554-559. PubMed PMID: 27439605; PubMed Central PMCID: PMC5227297.

11: Xing M, Simmonds RS, Timkovich R. Solution structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain of Zoocin A. Proteins. 2017 Jan;85(1):177-181. doi: 10.1002/prot.25178. Epub 2016 Oct 24. PubMed PMID: 27699884.

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15: Munegumi T. Epimerization of Alanyl-Alanine Induced by γ-Rays Irradiation in Aqueous Solutions. Orig Life Evol Biosph. 2017 Mar;47(1):69-82. doi: 10.1007/s11084-016-9507-0. Epub 2016 May 31. PubMed PMID: 27245350.

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