PAO-PDT

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562941

CAS#: 256348-71-7

Description: PAO-PDT is a highly selective small molecule inhibitor of thioredoxin reductase (TrxR).


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

PAO-PDT is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562941
Name: PAO-PDT
CAS#: 256348-71-7
Chemical Formula: C9H12AsNS2
Exact Mass: 272.9627
Molecular Weight: 273.24
Elemental Analysis: C, 39.56; H, 4.43; As, 27.42; N, 5.13; S, 23.47


Synonym: PAO-PDT; PAO PDT; PAOPDT;

IUPAC/Chemical Name: 2-(4-Aminophenyl)-1,3,2-dithiarsinane

InChi Key: WONBTYJJKXSAKA-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H12AsNS2/c11-9-4-2-8(3-5-9)10-12-6-1-7-13-10/h2-5H,1,6-7,11H2

SMILES Code: NC1=CC=C([As]2SCCCS2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Fan XY, Liu YJ, Chen K, Jiang FL, Hu YJ, Liu D, Liu Y, Ge YS. Organic arsenicals target thioredoxin reductase followed by oxidative stress and mitochondrial dysfunction resulting in apoptosis. Eur J Med Chem. 2018 Jan 1;143:1090-1102. doi: 10.1016/j.ejmech.2017.05.022. Epub 2017 May 6. PubMed PMID: 29150332.

2: Liu Y, Duan D, Yao J, Zhang B, Peng S, Ma H, Song Y, Fang J. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11. doi: 10.1021/jm500221p. Epub 2014 Jun 11. PubMed PMID: 24867309.